Patents by Inventor Paul J. Price

Paul J. Price has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8815573
    Abstract: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells. The invention also provides kits for use in the cultivation of a mammalian epithelial cell that comprise one or more containers, wherein a first container contains the culture medium of the invention. These kits may further comprise one or more additional containers containing one or more supplements.
    Type: Grant
    Filed: March 20, 2013
    Date of Patent: August 26, 2014
    Assignee: Life Technologies Corporation
    Inventors: Stephen F. Gorfien, Richard Fike, Glenn P. Godwin, Joyce L. Wolanske, David A. Epstein, Dale Gruber, Don McClure, Paul J. Price
  • Publication number: 20130065275
    Abstract: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.
    Type: Application
    Filed: September 10, 2012
    Publication date: March 14, 2013
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Stephen F. GORFIEN, Richard M. Fike, Glenn P. Godwin, Joyce L. Dzimian, David A. Epstein, Dale Gruber, Don McClure, Paul J. Price
  • Patent number: 8198084
    Abstract: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: June 12, 2012
    Assignee: Life Technologies Corporation
    Inventors: Stephen F. Gorfien, Richard M. Fike, Glenn P. Godwin, Joyce L. Dzimian, David A. Epstein, Dale Gruber, Don McClure, Paul J. Price
  • Publication number: 20090280533
    Abstract: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.
    Type: Application
    Filed: May 8, 2009
    Publication date: November 12, 2009
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Stephen F. Gorfien, Richard M. Fike, Glenn P. Godwin, Joyce L. Dzimian, David A. Epstein, Dale Gruber, Don McClure, Paul J. Price
  • Publication number: 20090280532
    Abstract: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.
    Type: Application
    Filed: May 8, 2009
    Publication date: November 12, 2009
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Stephen F. GORFIEN, Richard M. FIKE, Glenn P. GODWIN, Joyce L. DZIMIAN, David A. EPSTEIN, Dale GRUBER, Don McCLURE, Paul J. PRICE
  • Publication number: 20020076747
    Abstract: The present invention provides a serum-free supplement which supports the growth of embryonic stem cells in culture. Also provided are a medium comprising a basal medium supplemented with the serum-free supplement of the present invention. The present invention also provides methods for culturing and isolating embryonic stems cells, methods for producing a transgenic animal, and methods for expressing recombinant protein in embryonic stem cells and transgenic animals.
    Type: Application
    Filed: September 7, 1999
    Publication date: June 20, 2002
    Inventors: PAUL J. PRICE, MINDY D. GOLDSBOROUGH, MARY LYNN TILKINS
  • Patent number: 6180404
    Abstract: The present invention provides a minimal essential medium for maintaining neural cell or tissue viability in an environment containing ambient levels of CO2. The medium contains less than about 2000 &mgr;M bicarbonate, a buffer having a pKa of from about 6.9 to about 7.7, wherein the medium is free of ferrous sulfate, glutamate and aspartate, from 0 to about 3000 &mgr;M CaCl2, from about 0.05 to about 0.8 &mgr;M Fe(NO3)3, from about 2500 to about 10000 &mgr;M KCl, from 0 to about 4000 &mgr;M MgCl2, from about 74000 to about 103000 &mgr;M NaCl, from about 400 to about 2000 &mgr;M NaHCO3, from about 250 to about 4000 &mgr;M NaH2PO4, from about 0.2 to about 2 &mgr;M ZnSO4, from about 2500 to about 50000 &mgr;M glucose and from about 23 to about 500 &mgr;M sodium pyruvate. The present invention also provides a process of extending neural cell or tissue viability in an atmosphere having ambient levels of carbon dioxide whereby the neural cells or tissue are placed in such a medium.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: January 30, 2001
    Assignee: The Board of Trustees of Southern Illinois University
    Inventors: Gregory J. Brewer, Paul J. Price
  • Patent number: 6103529
    Abstract: The present invention provides serum-free cell culture media formulations which are capable of supporting the in vitro cultivation of animal cells. The media comprise at least one nutrient of plant derivation, such as at least one plant peptide and/or at least one plant lipid and/or at least one plant fatty acid. The media may further optionally comprise an enzymatic digest or extract of yeast cells. The present invention also provides methods of cultivating animal cells in vitro using these cell culture media formulations. In addition, the media of the present invention can be used for growth of animal cells for virus production.In particular, an animal cell culture medium comprising at least one peptide derived from rice, wherein said animal cell culture medium is completely devoid of animal-derived proteins.
    Type: Grant
    Filed: October 10, 1997
    Date of Patent: August 15, 2000
    Assignee: Life Technologies, Inc.
    Inventors: Paul J. Price, Steve Gorfien, Douglas Danner
  • Patent number: 5031781
    Abstract: A modular wallcovering display rack for providing a convenient and cost effective means of displaying wallpaper samples and the like to potential customers is disclosed. The wallcovering display rack is fabricated in modular form so that it may adapted to fit various store configurations and is also easily expandable. The wallcovering display rack comprises a plurality of vertically stacked, inclined shelves upon which individual sheets of wallcovering samples may be placed for display. Vertical columns support the shelves and house fluorescent lights which provide a soft, even illumination of the wallcovering samples. An individual wallcovering sample can be easily removed from the wallcovering rack for closer inspection. The ease of removal also facilitates rapid sample changes to reflect updates in inventory. Each vertical support column has an array of pockets positioned in alignment with and adjacent the stack of shelves.
    Type: Grant
    Filed: March 19, 1990
    Date of Patent: July 16, 1991
    Assignee: Dunn-Edwards Corporation
    Inventors: Paul J. Price, John D. Hufman, Edward D. Edwards
  • Patent number: 4369968
    Abstract: A lifting bar assembly comprising an elongated cylindrical rod over an intermediate portion of which a tube telescopically fits. A plurality of weight discs, each having a central hole and at least one hole adjacent the disc periphery are provided in abutting relationship with the ends of the tube and supported on the rod which extends through the selected hole. By selecting the hole adjacent the periphery, the assembly is highly useful for lifting in a room having a low ceiling, as in homes, so as to prevent bumping of the weights against the ceiling. As a bench press for lifting from the floor, a pair of support brackets, each having a plurality of vertically spaced holes through which the rod is slid, are supported on the floor and located between the ends of the tubes and the selected number of weights which are rigidly fastened to such ends by set screws on collars.
    Type: Grant
    Filed: February 5, 1981
    Date of Patent: January 25, 1983
    Inventor: Paul J. Price
  • Patent number: 4252316
    Abstract: A weight lifting bar having accessory plate hangers depending from each end of the bar to support weights at right angles or parallel to the bar at a selected distance below the bar so as to enable the bar to be used for exercising under certain conditions, such as when lifting the weights in the vicinity of a ceiling, or getting underneath the bar to be on the floor before lifting. The accessories are detachably removed to enable the weights to be slid and attached directly on the ends of the bar, as in conventionally used bars.
    Type: Grant
    Filed: April 2, 1979
    Date of Patent: February 24, 1981
    Inventor: Paul J. Price
  • Patent number: 4243219
    Abstract: A portable exercising device comprising a weight frame that may be leaned against the top of a door frame for support, which weight frame supports a weight sled or carriage carrying a selective number of weights. The carriage travels along the weight frame and can be pulled from selective heights, depending upon the position of the pulley on the frame about which a line, which is attached to the carriage, is reeved.
    Type: Grant
    Filed: August 11, 1978
    Date of Patent: January 6, 1981
    Inventor: Paul J. Price