Abstract: A medical device is configured to generate an acceleration signal and a temperature signal. The device is configured to determine an activity metric from the acceleration signal that is representative of patient physical activity. In response to determining that the activity metric is equal to or greater than a previously determined activity metric, the device is configured to adjust a target cardiac pacing rate based at least on a temperature change determined from the temperature signal. The device may include a pulse generator for generating cardiac pacing pulses based on the target cardiac pacing rate.

Abstract: Implantable medical systems enter an exposure mode of operation, either manually via a down linked programming instruction or by automatic detection by the implantable system of exposure to a magnetic disturbance. A controller then determines the appropriate exposure mode by considering various pieces of information including the device type including whether the device has defibrillation capability, pre-exposure mode of therapy including which chambers have been paced, and pre-exposure cardiac activity that is either intrinsic or paced rates. Additional considerations may include determining whether a sensed rate during the exposure mode is physiologic or artificially produced by the magnetic disturbance. When the sensed rate is physiologic, then the controller uses the sensed rate to trigger pacing and otherwise uses asynchronous pacing at a fixed rate.

Abstract: One or more biocatalysts or a combinatorial array of biocatyalysts is produced by providing a host cell; recombining at least two biotransformation genes for modifying a chemical substrate into the host cell; and thereby producing at least one recombinant strain comprising a biocatalysts. Additionally, the screening of cells having at least two distinct biotransforming catalysts combined therein may be performed by providing multiple wells, each of the multiple wells containing cells having at least two distinct biotransforming catalysts combined therein; and providing multiple wells, each of the wells containing different cells having at least two distinct biotransforming catalysts combined therein; and then allowing cells within the well to catalyze a reaction with a compound within each well, and analyzing the results of any reactions within each well to determine any functional activity of cells within each well.