Abstract: Methods and structure are provided for routing internal operational signals of a circuit for output via an external interface. The structure includes an integrated circuit. The integrated circuit comprises a block of circuitry components operable to generate internal operational signals for performing designated functions during normal operation of the circuit, a control unit, a test signal routing hierarchy, and an external interface. The test signal routing hierarchy is coupled to receive the internal operational signals and controllably selects the internal operational signals for acquisition and applies them to the control unit. The external interface provides communications between the integrated circuit and an external device during normal operation of the integrated circuit.

Abstract: Methods and structure for correlating internal operational signals routed via different paths of a test signal selection hierarchy. The structure includes a functional block of circuitry operable to generate internal operational signals and clock signals. The integrated circuit also comprises a test signal selection hierarchy operable to receive the internal operational signals and the clock signals and to selectively route the internal operational signals and the clock signals. Further, structure includes a control unit operable to receive the clock signals from the test signal selection hierarchy, to determine a delay between received clock signals routed via different signaling pathways of the test signal selection hierarchy. The control unit is further operable to program a delay line based upon the delay between the clock signals and based upon internal operational signals correlated with the clock signals.

Abstract: An apparatus that restricts or disables electronic device functionality based on vehicle status data received from the on-board computer (“OBD”) of a public service vehicle. In some embodiments, the vehicle status data is accessed from the OBD through an assembly line diagnostic link (“ALDL”) connector, which eliminates any need for modification of the vehicle during installation. If the software determines the vehicle status data is outside a preset range, which could be customized on a case-by-case basis, the on-board computer of the vehicle could be restricted or disabled until the vehicle status data returns to within the preset range.

Abstract: Described herein are various systems and methods for directing endoscopy instruments to varying positions at a target site. In one aspect, at least one instrument channel has multiple exit points at the distal end of the guide tube, and the position of an instrument delivered through the channel may be switched between the different exit points. In another aspect, an instrument channel splits into multiple branches at the distal end of the guide tube, and the position of an instrument at the target site may be changed by selectively directing the instrument into a different channel branch. In yet another aspect, the guide tube, or a portion thereof, may be rotated to reposition an instrument at the target site. The capability of changing the instrument positions during a procedure would enable a physician to examine or treat multiple target sites within an operative field, without necessitating the full retraction of the instruments or the guide tube from the operative field.

Abstract: Disclosed herein are various systems and methods for facilitating control of a tool or tools. The systems can allow a user to control multiple degrees of freedom. One such system allows a user to control multiple degrees of freedom of two tools simultaneously. Another such system allows a user to control multiple degrees of freedom with a single hand. Frames and rails for supporting and/or constraining movement of a tool or tools are also described herein.

Abstract: There is provided a cell culture microtrench being defined on or in a surface of a substrate, wherein the ratio of the width of the microtrench to the maximum length of the short axis of a cell type of interest is about 6 or preferably less, the length of the short axis of the cell type being measured when a cell is in detached or suspended form. There is also provided an array comprising such a microtrench and uses of such microtrenches, including cell-based assays.

Abstract: Described herein are various systems and methods for directing endoscopy instruments to varying positions at a target site. In one aspect, at least one instrument channel has multiple exit points at the distal end of the guide tube, and the position of an instrument delivered through the channel may be switched between the different exit points. In another aspect, an instrument channel splits into multiple branches at the distal end of the guide tube, and the position of an instrument at the target site may be changed by selectively directing the instrument into a different channel branch. In yet another aspect, the guide tube, or a portion thereof, may be rotated to reposition an instrument at the target site. The capability of changing the instrument positions during a procedure would enable a physician to examine or treat multiple target sites within an operative field, without necessitating the full retraction of the instruments or the guide tube from the operative field.

Abstract: Systems and methods are described for developing studies such as clinical trials, including computer-assisted recruitment or selection of patients, clinical trial investigators, facilities, or clinical trial study sites. In certain examples, computer-processing of physician records scores physicians potential investigators, as determined from at least one physician characteristic, and the physician's proximity to the nearest clinical trial study site. Clinical trial study sites are also scored. In certain examples, at least one physician characteristic is used to score potential clinical trial study sites. Processes for engaging physicians and their patients in clinical trial studies are also described. Suitable patients can be contacted through their physicians or other caregivers to participate in the clinical trial study.

Abstract: A system including an overtube configured to radially expand facilitates insertion of instruments in a patient. The system is directed to an overtube comprising an elongated body having a distal end and a proximal end, the overtube configured to radially expand from an insertion configuration to an expanded configuration, and including at least one articulation section having at least one degree of freedom and including a main channel expandable in the radial direction, and at least one additional channel. The at least one articulation section can radially expand. The system may include a radially expandable overtube having an optical channel configured to receive an optical device. The main channel and/or the at least one additional channel may be sized to receive one or more medical instruments.

Abstract: Circuits and associated methods for testing internal operation of an application integrated circuit. Features and aspects hereof add configurable test interrupt circuits to an application circuit design to permit dynamic, configurable interrupt generation from an integrated circuit based on conditions determined from monitoring of internal signals of the application circuit. The internal signals that may be tested and used to generate test interrupts are those not exposed to the external processor interface of the integrated circuit and thus may be configured to interrupt based on any internal state of the application specific functional circuits of the integrated circuit.

Abstract: A filtration unit having an inlet to, and outlet from, a filtration zone in which one or more filter elements are located, the filtration zone being located above a collection zone, the collection zone comprising powered movement means operable to cause particulate matter contacting such movement means to be urged towards storage means.

Abstract: Embodiments of the invention may be directed to apparatuses for securing and sealing tissue and related methods of use.

Abstract: Embodiments of the invention include endoscopic guide tubes having a retractor and a stabilizing assembly for use with the guide tube and related methods of use.

Abstract: Disclosed herein are various systems and methods for traversing an anatomic wall. A system can include a port that mates with an anatomic wall and provides a lumen for the passage of a guide tube of a transluminal device. The port can inhibit the passage of biological materials through the anatomic wall. Further described herein are methods for implanting the port and/or for inserting the transluminal device into a body cavity.

Abstract: Embodiments of the invention may be directed to apparatuses for securing and sealing apertures in tissue and related methods of use.

Abstract: Disclosed herein are various systems and methods for guiding, supporting, and/or housing instruments. One exemplary system includes a guide tube having a manipulation section and mated with rails carrying instrument control members. Moving the rails with respect to the guide tube, or another point of reference, can control movement of the manipulation section.

Abstract: Disclosed herein are various instruments, systems, and methods of use. The instruments can have various control members and/or handles for controlling various degrees of freedom. In addition, the control members can include various control mechanisms for transferring user inputs from a handle to a distal portion of the instrument. In one aspect, an instrument can comprise a control member and a catheter. The catheter can be adjustably and/or detachably connected to the control member.

Abstract: Disclosed herein are various systems and methods for facilitating control of a tool or tools. The systems can allow a user to control multiple degrees of freedom. One such system allows a user to control multiple degrees of freedom of two tools simultaneously. Another such system allows a user to control multiple degrees of freedom with a single hand. Frames and rails for supporting and/or constraining movement of a tool or tools are also described herein.

Abstract: Described herein are drive systems and methods. One exemplary system includes a tool having a proximal handle and a catheter body. The tool can be mated with a rail and the rail mated with a frame. The connection between the tool and rail and/or the rail and frame can allow relative movement of the tool with respect to the frame, a patient, and/or a point of reference. In one exemplary configuration the handle of the tool rotates around an axis that corresponds to a portion of the catheter body, such that rotational movement of the handle has a minimal impact on longitudinal movement and/or position of a distal end of the tool.

Abstract: Described herein are multi-part instrument systems and methods of use. The instrument can include an inner and outer body member where the inner body member is adapted to dock with the outer body member. When docked, driving the outer body member via a manipulation section can control the inner body. In use, an inner body member can be removed and replaced by a different inner body member to change the tool end effector. Alternatively, driving a manipulation section of the inner body member can control the outer body member. The outer body member can be disposable while the inner body member is reusable.