Patents by Inventor Paul J. Tesar

Paul J. Tesar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND METHODS OF PROMOTING MYELINATION
    Publication number: 20230000798
    Abstract: A method of promoting the generation of oligodendrocytes from oligodendrocyte precursor cells by enhancing their survival and/or maturation includes administering to the cell an effective amount of an agent that enhances and/or induces accumulation of ?8,9-unsaturated sterol intermediates of the cholesterol biosynthesis pathway in the oligodendrocyte precursor cells.
    Type: Application
    Filed: May 27, 2022
    Publication date: January 5, 2023
    Inventors: Paul J. Tesar, Drew Adams, Zita Hubler, Matthew Elitt, Dharmaraja Allimuthu, Steven B. Landau
  • COMPOUNDS FOR TREATING MYELIN RELATED DISORDERS
    Publication number: 20210353642
    Abstract: Disclosed is a pharmaceutical composition comprising a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a myelin related disorder in a subject, the method comprising administering to the subject an effective amount of a compound of Structural Formula (I) or a pharmaceutical composition comprising the compound of Structural Formula (I). The variables of Structural Formula (I) are described herein.
    Type: Application
    Filed: October 1, 2019
    Publication date: November 18, 2021
    Inventors: Drew Adams, Paul J. Tesar, Dharmaraja Allimuthu, Zita Hubler, Fadi J. Najm
  • Method of promoting remyelination
    Patent number: 10653691
    Abstract: A method of promoting remyelination in a subject in need thereof includes administering to the subject a therapeutically effective amount of at least one (1,3) Diazole compound, wherein the therapeutically effective amount is the amount effective to induce endogenous oligodendrocyte precursor cell (OPC) differentiation in the subject's central nervous system.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: May 19, 2020
    Assignee: Case Western Reserve University
    Inventors: Paul J. Tesar, Fadi J. Najm, Robert H. Miller
  • METHOD OF PROMOTING REMYELINATION
    Publication number: 20190209554
    Abstract: A method of promoting remyelination in a subject in need thereof includes administering to the subject a therapeutically effective amount of at least one (1,3) Diazole compound, wherein the therapeutically effective amount is the amount effective to induce endogenous oligodendrocyte precursor cell (OPC) differentiation in the subject's central nervous system.
    Type: Application
    Filed: December 21, 2018
    Publication date: July 11, 2019
    Inventors: Paul J. Tesar, Fadi J. Najm, Robert H. Miller
  • Cell fate conversion of differentiated somatic cells into glial cells
    Patent number: 10119123
    Abstract: The present invention relates to the reprogramming of differentiated somatic cells, such as those differentiated cells that arise from embryonic mesoderm, into glial cells. Glial cells produced from this reprogramming are functionally equivalent to glial cells that arise from ectodermal origins.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: November 6, 2018
    Assignee: Case Western Reserve University
    Inventors: Paul J. Tesar, Robert H. Miller, Fadi J. Najm
  • Differntiation method for production of glial cell population
    Patent number: 9969974
    Abstract: The present invention provides methods for generating oligodendrocyte progenitor cells from pluripotent cells, as well as methods for sustaining these oligodendrocyte progenitor cells in relatively pure cultures for long periods of time. The present invention also provides methods for further differentiating these oligodendrocyte progenitor cells into various glial cells.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: May 15, 2018
    Assignee: Case Western Reserve University
    Inventors: Paul J. Tesar, Robert H. Miller, Fadi J. Najm
  • CELL FATE CONVERSION OF DIFFERENTIATED SOMATIC CELLS INTO GLIAL CELLS
    Publication number: 20180051259
    Abstract: The present invention relates to the reprogramming of differentiated somatic cells, such as those differentiated cells that arise from embryonic mesoderm, into glial cells. Glial cells produced from this reprogramming are functionally equivalent to glial cells that arise from ectodermal origins.
    Type: Application
    Filed: November 8, 2016
    Publication date: February 22, 2018
    Inventors: Paul J. Tesar, Robert H. Miller, Fadi J. Najm
  • Glial cells and oligodendrocytes produced by reprogramming somatic cells with Sox10, Olig2 and Nkx6.2
    Patent number: 9487757
    Abstract: The present invention relates to the reprogramming of differentiated somatic cells, such as those differentiated cells that arise from embryonic mesoderm, into glial cells. Glial cells produced from this reprogramming are functionally equivalent to glial cells that arise from ectodermal origins.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: November 8, 2016
    Assignee: Case Western Reserve University
    Inventors: Paul J. Tesar, Robert H. Miller, Fadi J. Najm
  • DIFFERNTIATION METHOD FOR PRODUCTION OF GLIAL CELL POPULATION
    Publication number: 20160075994
    Abstract: The present invention provides methods for generating oligodendrocyte progenitor cells from pluripotent cells, as well as methods for sustaining these oligodendrocyte progenitor cells in relatively pure cultures for long periods of time. The present invention also provides methods for further differentiating these oligodendrocyte progenitor cells into various glial cells.
    Type: Application
    Filed: November 23, 2015
    Publication date: March 17, 2016
    Inventors: Paul J. Tesar, Robert H. Miller, Fadi J. Najm
  • Differentiation method for production of glial cell populations
    Patent number: 9193951
    Abstract: The present invention provides methods for generating oligodendrocyte progenitor cells from pluripotent cells, as well as methods for sustaining these oligodendrocyte progenitor cells in relatively pure cultures for long periods of time. The present invention also provides methods for further differentiating these oligodendrocyte progenitor cells into various glial cells.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: November 24, 2015
    Assignee: Case Western Reserve University
    Inventors: Paul J. Tesar, Robert H. Miller, Fadi J. Najm
  • DIFFERENTIATION METHOD FOR PRODUCTION OF GLIAL CELL POPULATIONS
    Publication number: 20120100113
    Abstract: The present invention provides methods for generating oligodendrocyte progenitor cells from pluripotent cells, as well as methods for sustaining these oligodendrocyte progenitor cells in relatively pure cultures for long periods of time. The present invention also provides methods for further differentiating these oligodendrocyte progenitor cells into various glial cells.
    Type: Application
    Filed: October 25, 2011
    Publication date: April 26, 2012
    Applicant: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Paul J. Tesar, Robert H. Miller, Fadi J. Najm
  • CELL FATE CONVERSION OF DIFFERENTIATED SOMATIC CELLS INTO GLIAL CELLS
    Publication number: 20120100615
    Abstract: The present invention relates to the reprogramming of differentiated somatic cells, such as those differentiated cells that arise from embryonic mesoderm, into glial cells. Glial cells produced from this reprogramming are functionally equivalent to glial cells that arise from ectodermal origins.
    Type: Application
    Filed: October 25, 2011
    Publication date: April 26, 2012
    Applicant: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Paul J. Tesar, Robert H. Miller, Fadi J. Najm