Patents by Inventor Paul J. Zakrevsky

Paul J. Zakrevsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hexameric tetrahedral RNA nanostructures
    Patent number: 11666663
    Abstract: Disclosed are nanostructures comprising a ribonucleic acid (RNA) scaffold comprising a hexameric tetrahedral core. The tetrahedral core may comprise four hexameric RNA nanorings linked together. Related pharmaceutical compositions, methods of modulating the expression of a target gene in a mammal, methods of treating or preventing a disease in a mammal, and methods of producing a hexameric tetrahedral RNA nanostructure are also disclosed.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: June 6, 2023
    Assignees: The United States of America,as represented by the Secretary, Department of Health and Human Services, The Regents of the University of California
    Inventors: Bruce A. Shapiro, Paul J. Zakrevsky, Luc Jaeger
  • HYBRID NUCLEIC ACID SWITCHES
    Publication number: 20220177890
    Abstract: Disclosed are DNA/RNA hybrid nucleic acid nanoparticles comprising at least one trigger toehold or at least one exchange toehold, wherein each at least one trigger toehold and the at least one exchange toehold independently comprise DNA and/or RNA, and at least one single stranded RNA output strand, wherein no portion of the at least one trigger toehold hybridizes to any portion of the at least one output strand, the at least one trigger toehold is complementary and hybridizes to a first target sequence when the nanoparticle is in the presence of the first target sequence, and the nanoparticle does not contain the target sequence. Related pharmaceutical compositions, methods of treating a patient with a disease or condition, and methods of diagnosing a patient with a disease or condition are also disclosed.
    Type: Application
    Filed: April 10, 2020
    Publication date: June 9, 2022
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Bruce A. Shapiro, Paul J. Zakrevsky
  • HEXAMERIC TETRAHEDRAL RNA NANOSTRUCTURES
    Publication number: 20210069345
    Abstract: Disclosed are nanostructures comprising a ribonucleic acid (RNA) scaffold comprising a hexameric tetrahedral core. The tetrahedral core may comprise four hexameric RNA nanorings linked together. Related pharmaceutical compositions, methods of modulating the expression of a target gene in a mammal, methods of treating or preventing a disease in a mammal, and methods of producing a hexameric tetrahedral RNA nanostructure are also disclosed.
    Type: Application
    Filed: May 8, 2019
    Publication date: March 11, 2021
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, The Regents of the University of California
    Inventors: Bruce A. Shapiro, Paul J. Zakrevsky, Luc Jaeger