Patents by Inventor Paul J. Zalesky
Paul J. Zalesky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6454997Abstract: A gas-enriched fluid is provided by the combination of a first fluid, such as a patient's blood, with a second gas-supersaturated fluid, such as an oxygen supersaturated fluid. In this example, a catheter assembly includes a portion that receives the patient's blood from a pump and that receives the oxygen supersaturated fluid from an appropriate fluid source. The oxygen supersaturated fluid is advantageously combined with the blood in an area of laminar flow, and then this gas-enriched fluid is delivered to the patient through an appropriate lumen coupled to the portion of the catheter assembly.Type: GrantFiled: July 24, 1998Date of Patent: September 24, 2002Assignee: TherOx, Inc.Inventors: Vincent Divino, Jr., Seth A. Foerster, James M. Gessert, Robert A. Mest, Paul J. Zalesky
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Publication number: 20020040232Abstract: The present invention is a device for insertion into a human or animal body, in a preferred embodiment a perfusion guidewire capable of delivering perfusion fluids to a vascular site while at the same time exhibiting handling characteristics associated with existing non-perfusion guidewires. Preferred embodiments include a perfusion guidewire which closely matches the dimensions and physical characteristics of standard guidewires. Preferred embodiments also permit high pressure perfusion of oxygen-supersaturated solutions, and include a diffuser segment which divides the flow and reduces fluid velocity, thereby providing an a traumatic, non-cavitating, bubble-free delivery to the patient. The invention also encompasses the attachment of a core wire within a tubular housing to provide superior characteristics to such guidewires, balloon catheters and similar devices.Type: ApplicationFiled: May 16, 2001Publication date: April 4, 2002Inventors: Vincent Divino, Jr., John Merritt, Seth A. Foerster, William C. Homet, Paul J. Zalesky
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Publication number: 20010016729Abstract: An apparatus and method for blood oxygenation is provided, advantageously comprising an extracorporeal circuit for the preparation and delivery of hyperoxic or hyperbaric blood. In one embodiment, an apparatus for gas-supersaturating fluids, e.g., physiologic saline, includes a chamber having a first inlet to receive the fluid; a second inlet to receive a gas, e.g., oxygen, from a gas supply that maintains pressure within the chamber at a predetermined level, advantageously about 600 p.s.i.; and an outlet advantageously coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet advantageously creates within the chamber fine droplets of fluid into which gas diffuses to create the gas-supersaturated fluid, which collects within the chamber below the atomizer nozzle for removal via the outlet.Type: ApplicationFiled: February 7, 2001Publication date: August 23, 2001Inventors: Vincent Divino, Paul J. Zalesky, William R. Patterson
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Patent number: 6248087Abstract: A system and method for increasing gas concentration in blood which has use as a generalized extracorporeal system and method to treat hypoxemic blood from a patient by mixing the blood with an oxygen supersaturated solution to generate hyperoxemic blood to be infused back to the patient. The extracorporeal system comprises an extracorporeal tubing through which blood from the patient is circulated, a blood pump for withdrawing blood from and delivering blood to the patient, at least one channel for delivering oxygen-supersaturated fluid and a mixing region for introducing supersaturated fluid without bubble formation. By infusing the oxygen-supersaturated fluid into the hypoxemic or normoxemic blood from the patient, hyperoxemic blood is thereby produced. The hyperoxemic blood is then returned to a central vein, right heart or artery of the patient with the blood pump at approximately the same volume delivery rate as blood volume withdrawal rate.Type: GrantFiled: January 27, 1999Date of Patent: June 19, 2001Assignees: Therox, Inc., Wayne State UniversityInventors: J. Richard Spears, Seth A. Foerster, James M. Gessert, Paul J. Zalesky
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Patent number: 6235007Abstract: The present invention is a device for insertion into a human or animal body, in a preferred embodiment a perfusion guidewire capable of delivering perfusion fluids to a vascular site while at the same time exhibiting handling characteristics associated with existing non-perfusion guidewires. Preferred embodiments include a perfusion guidewire which closely matches the dimensions and physical characteristics of standard guidewires. Preferred embodiments also permit high pressure perfusion of oxygen-supersaturated solutions, and include a diffuser segment which divides the flow and reduces fluid velocity, thereby providing an atraumatic, non-cavitating, bubble-free delivery to the patient. The invention also encompasses the attachment of a core wire within a tubular housing to provide superior characteristics to such guidewires, balloon catheters and similar devices.Type: GrantFiled: June 5, 1998Date of Patent: May 22, 2001Assignee: TherOx, Inc.Inventors: Vincent Divino, Jr., John Merritt, Seth A. Foerster, William C. Homet, Paul J. Zalesky
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Publication number: 20010001111Abstract: A system and method for increasing gas concentration in blood which has use as a generalized extracorporeal system and method to treat hypoxemic blood from a patient by mixing the blood with an oxygen supersaturated solution to generate hyperoxemic blood to be infused back to the patient. The extracorporeal system comprises an extracorporeal tubing through which blood from the patient is circulated, a blood pump for withdrawing blood from and delivering blood to the patient, at least one channel for delivering oxygen-supersaturated fluid and a mixing region for introducing supersaturated fluid without bubble formation. By infusing the oxygen-supersaturated fluid into the hypoxemic or normoxemic blood from the patient, hyperoxemic blood is thereby produced. The hyperoxemic blood is then returned to a central vein, right heart or artery of the patient with the blood pump at approximately the same volume delivery rate as blood volume withdrawal rate.Type: ApplicationFiled: December 19, 2000Publication date: May 10, 2001Inventors: J. Richard Spears, Seth A. Foerster, James M. Gessert, Paul J. Zalesky
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Patent number: 6180059Abstract: A gas-enriched fluid is provided by the combination of a first fluid, such as a patient's blood, with a second gas-supersaturated fluid, such as an oxygen supersaturated fluid. In this example, a catheter assembly includes a portion that receives the patient's blood from a pump and that receives the oxygen supersaturated fluid from an appropriate fluid source. The oxygen supersaturated fluid is advantageously combined with the blood in an area of laminar flow, and then this gas-enriched fluid is delivered to the patient through an appropriate lumen coupled to the portion of the catheter assembly.Type: GrantFiled: July 24, 1998Date of Patent: January 30, 2001Assignee: TherOx, Inc.Inventors: Vincent Divino, Jr., Seth A. Foerster, James M. Gessert, Robert A. Mest, Paul J. Zalesky, James Richard Spears
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Patent number: 6123698Abstract: The present invention includes a fluid delivery device capable of delivering perfusion or other fluids to a vascular site. Preferred embodiments permit delivery of large quantities of fluid without causing recoil of the device, and without causing trauma to the vascular site.Type: GrantFiled: May 14, 1999Date of Patent: September 26, 2000Assignees: Therox, Inc., Wayne State UniversityInventors: J. Richard Spears, Philip S. Levin, Paul J. Zalesky, Vincent Divino, Jr.
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Patent number: 5976119Abstract: The present invention includes a guidewire device capable of delivering perfusion fluids to a vascular site while at the same time exhibiting handling characteristics associated with existing non-perfusion guidewires. Preferred embodiments include a perfusion guidewire which closely matches the dimensions and physical characteristics of standard guidewires. Preferred embodiments also permit high pressure perfusion of supersaturated solutions, and include a liquid flow path which will not promote bubble generation or growth, or destabilize a supersaturated solution.Type: GrantFiled: August 21, 1998Date of Patent: November 2, 1999Assignees: Wayne State University, TherOx, Inc.Inventors: J. Richard Spears, Philip S. Levin, Paul J. Zalesky
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Patent number: 5957899Abstract: The present invention includes a fluid delivery device capable of delivering perfusion or other fluids to a vascular site. Preferred embodiments permit delivery of large quantities of fluid without causing recoil of the device, and without causing trauma to the vascular site.Type: GrantFiled: June 24, 1996Date of Patent: September 28, 1999Assignee: TherOx, Inc.Inventors: J. Richard Spears, Philip S. Levin, Paul J. Zalesky, Vincent Divino, Jr.
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Patent number: 5797876Abstract: The present invention includes a guidewire device capable of delivering perfusion fluids to a vascular site while at the same time exhibiting handling characteristics associated with existing non-perfusion guidewires. Preferred embodiments include a perfusion guidewire which closely matches the dimensions and physical characteristics of standard guidewires. Preferred embodiments also permit high pressure perfusion of supersaturated solutions, and include a liquid flow path which will not promote bubble generation or growth, or destabilize a supersaturated solution.Type: GrantFiled: November 27, 1995Date of Patent: August 25, 1998Assignees: Therox, Inc., Wayne State UniversityInventors: J. Richard Spears, Philip S. Levin, Paul J. Zalesky
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Patent number: 5115814Abstract: An intravascular ultrasonic imaging probe includes a transducer subassembly adapted to being rotated within a guide catheter via a drive cable. The guide catheter establishes a bearing surface for supporting the transducer subassembly during rotation while also mechanically isolating the rotating transducer subassembly from surrounding tissue (thereby protecting the tissue from inadvertent and/or undesired tissue abrasion by the subassembly during rotation). The catheter is positioned within a vessel to be imaged by telescopically advancing the same over a previously positioned guide wire, the guide wire being withdrawn after the guide catheter is positioned. Thereafter, the imaging probe is inserted into the guide catheter and operated so as to obtain ultrasonic images of the vessel under investigation.Type: GrantFiled: August 18, 1989Date of Patent: May 26, 1992Assignee: InterTherapy, Inc.Inventors: James M. Griffith, Paul J. Zalesky, James M. Gessert, Viet P. Dinh, James D. Passafaro
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Patent number: 5069664Abstract: A probe for ultrasonically removing unwanted biological material, for example, from a vessel in a patient's cardiovascular system, includes a catheter assembly having distal and proximal catheter sections, each defining a respective lumen. A subassembly is connected to and between these catheter sections and houses piezoceramic transducer elements which are adapted to vibrate at ultrasonic frequencies. An elongate flexible working element (e.g., one or more wire elements) is housed within the distal catheter section and projects beyond that section's distal end so as to be adapted to contact unwanted biological material. The proximal end of the working element is coupled to the transducer elements via ultrasonic coupling structures so as to responsively vibrate at ultrasonic frequencies.Type: GrantFiled: January 25, 1990Date of Patent: December 3, 1991Assignee: Inter Therapy, Inc.Inventors: Joe F. Guess, Paul J. Zalesky
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Patent number: 4841977Abstract: An array of miniature ultrasound crystals mounted on preassembled subassembly which is, in turn, mounted on a small lumen catheter provides dimensional and other quantitative information relating to arterial wall geometry and character at disease or obstruction sites. Balloons also mounted to the catheter make it possible to use the catheter for the angioplasty (PCTA) procedure while actually imaging, in real time, the artery being dilatated and unblocked by the procedure. Efficient, highly miniature transducers are presented along with several different configurations for catheter structure containing fluid lumen, through-lumen, and electrical microcable assemblies for conducting electrical signals to and from the transducers.Type: GrantFiled: May 26, 1987Date of Patent: June 27, 1989Assignee: Inter Therapy, Inc.Inventors: James M. Griffith, Mario Maciel, Walter L. Henry, Paul J. Zalesky