Abstract: The use of compounds of the formula (I) Ar1-L1-Ar2-L2-C(R3)(R4)N(OR1)C(?Y)—R2 (I) where Y is selected from O or S; R1 is H, a salt or readily hydrolysable substituent; R2 is selected from H or CH3, CH2F, CF2H or CF3; R3 and R4 are selected independently from H, C 1-4 alkyl or alkenyl, CF3, CH2F, CF2H and F, with the proviso that if either R3 or R4 is H, then the other is not H; L1 is a linker group; L2 is a linker group comprising an optionally substituted or unsubstituted unsaturated branched or straight chain alkyl group; Ar1 is an optionally substituted or unsubstituted aryl or heterocyclic group; and Ar2 is an optionally substituted or unsubstituted aryl or heterocyclic group, in the treatment of 5-lipoxygenase mediated cancer provide improved therapies due to the effective inhibition of 5-lipoxygenase and long duration of activity in vivo after oral administration.

Abstract: A method of defining data objects for use with an executable block diagram modeling and code generation system including providing pre-defined data object classes, each of the pre-defined data classes having default attributes, extending the pre-defined data object classes with subclasses, each of the subclasses having user-defined attributes and generating data objects, which are instances of the pre-defined classes and the subclasses.

Abstract: This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.

Abstract: This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.

Abstract: An apparatus and method are disclosed for error correction code (“ECC”) striping. A memory receives sets of data in an original order. The memory stores the sets of data row by row in rows and columns such that user data in each row follows the original order. Each set of data is stored in a different row. An ECC data generator is coupled to the memory. The ECC data generator generates ECC data for each set of data in each row. The ECC data generator appends the generated ECC data to an end of each corresponding row. A modulator device is also coupled to the memory. The modulator device extracts the combined sets of data and ECC data in a striped order comprising a column by column order. A column comprises data from each row.

Abstract: A method is disclosed which decreases the amount of error correction code data required to detect and correct errors in digital data while still maintaining a specified ability to correct errors in large groups of contiguous data. The present invention accomplishes this by placing distance either in space or in time between bytes grouped mathematically for error correction code calculations. An error affecting contiguous bytes, like scratches or other defects in digital storage media, or certain types of interference in either wired or wireless digital communications, would affect many error correction code groups, but would only affect one byte from each group. The error can easily be corrected using only a one dimensional error correction code, removing the need for a two dimensional product error correction code and the additional data overhead that the column ECC data necessarily adds to the block.

Abstract: A model workspace that has a close relationship with a model is disclosed. The model workspace may contain data associated with the model, such as data defining data types and values of variables in the model. The data in the model workspace are visible in the scope of the model. The model workspace may be initialized from a data repository including a plurality of data sources. The data sources may include persistent data sources, such as a model file, an external data file and a computer program, and interfaces, such as command line interfaces and graphical user interfaces. The model workspace can be reinitialized from different data sources and can be stored into different data sources.

Abstract: In an embodiment, a technique for acquiring a class definition of a class, the class associated with an enumeration, the enumeration enumerating a partial list of instances of the class; generating a data structure based on the class definition, the data structure associating one or more identifiers with an instance enumerated in the enumeration; and storing the data structure in a computer storage

Abstract: This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.

Abstract: The current disclosure provide a novel human calcium sensing receptor named CaR2 and the nucleotide sequence that encodes the receptor. The disclosure further provides antibodies specific for CaR2. Also disclosed are methods of identifying modulators of the receptor and methods of using the identified modulators to treat calcium receptor mediated conditions.

Abstract: An integrated, low profile, high power laser light emission device is disclosed. The integrated laser light emission device provides uniform heat dissipation, as well as uniform pumping of the laser gain medium without the need for a pumping cavity. The laser system includes a pump diode array that can be mounted directly to a laser gain medium without intervening correcting optics hardware. Heat generated by the laser light emission device is cooled by a single cooling system. In the laser device, a pump diode array is preferably a Vertical-Cavity Surface-Emitting Laser (VCSEL) array. VCSEL arrays are mounted on the laser gain crystal by a metal cavity frame or metal stilts. The slightly elevated mounting of the VCSEL's enables increased cooling and maximizing the quantity of VCSEL's on the laser gain medium in order to achieve highly efficient and high power laser light output.

Abstract: A process for preparing 10,11-dihydro-5H-dibenzo[a,d]cyclohept-5-enes (e.g. loratadine) by reacting a dibenzozuberone with an aliphatic ketone in the presence of low valent titanium.

Abstract: The invention relates to the provision of data to a viewer of a television system. In particular the information is provided in a visual and/or audible indication to the viewer of a selected program as to when the next program in that program series is scheduled to be shown. The identity and schedule data is retrieved from data received relating to the generation of an EPG or alternatively from the data broadcast along with the selected program being viewed.

Abstract: An improved process for the manufacture of fexofenadine is described in which a compound of formula (F): wherein R2 represents COOH, COO—C1-6 alkyl or CN; and R3 represents hydrogen, mesylate, triflate, tosylate or carboxy-C1-6-alkyl, or a salt thereof is prepared by: (I) reacting a compound of formula (B): wherein R1 represents hydrogen or carboxy-C1-6-alkyl; and R2 is a hereinbefore defined, with a copper and/or silver compound in the presence of palladium or a compound thereof to yield a compound of formula (C): wherein R1, and R2 are as hereinbefore defined; (II) converting said compound of formula (C) into a compound of formula (E): wherein R2 and R3 are as hereinbefore defined and R4 represents a halogen atom, and (III) reacting said compound of formula (E) with azacyclonol.

Abstract: Software for building a block diagram representation of a system includes instructions for defining a propagation block having an input port for receiving information indicative of an attribute set of an input signal and an output port for providing information indicative of an attribute set of an output signal on the basis of the attributes of the input signal. The software includes instructions for associating, with the propagation block, a rule-set for determining the output attribute set on the basis of the input attribute-set.

Abstract: This invention provides novel arylindenopyridines of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing Adensine A2a receptors or reducing PDE activity in appropriate cells. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.

Abstract: A cutting blade (56) having a cutting edge (80) defined by an intersection of a first cutting edge surface (72) and a second cutting edge surface (66) is disclosed. The angle between the first cutting edge surface (72) and the second cutting edge surface (66) defines a blade angle (?). The blade (56) may be fabricated from a wafer (130) by an anisotropic etch. An upper surface (134) of the wafer (130) is defined by a first set of 3 Miller indices, where at least one individual Miller index of this first set has an absolute value greater than 3. A top surface (60) of the blade (56) is defined by part of the upper surface (134) of the wafer (130). The anisotropic etch proceeds until reaching a particular crystallographic plane to define the first cutting edge surface (72). Having the top surface (60) of the blade (56) defined by the noted set of 3 Miller indices increases the potential that a blade angle (?) of a desired magnitude may be realized.

Abstract: A microelectromechanical system is disclosed that constrains the direction of a force acting on a first load, where the force originates from the interaction of the first load and a second load. In particular, the direction of a force acting on the first load is caused to be substantially parallel with a motion of the first load. This force direction constraint is achieved by a force isolator microstructure that contains no rubbing or contacting surfaces. Various embodiments of structures/methods to achieve this force direction constraint using a force isolator microstructure are disclosed.

Abstract: A bag for granular products, made of heat sealable film, having an integral handle within the top sealed portion of the bag that fits into and is secured within an opening in the bottom sealed portion of the bag, whereby the bag can be securely re-closed after opening by folding the top portion of the bag over toward the bottom portion of the bag, and securing the integral handle within the opening.

Abstract: A process for primer coating a steel substrate with a primer coating comprising a silica binder, wherein the binder comprises an aqueous silica sol having a SiO2/M2O mole ratio, wherein M represents the total of alkali metal and ammonium ions, of at least 6:1, and wherein after the primer coating has dried to the extent that it is touch dry, the coated substrate is immersed in water or alternatively kept in an atmosphere with a relative humidity of at least 50%.