Patents by Inventor Paul John Simmons

Paul John Simmons has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolation of adult multipotential cells by tissue non-specific alkaline phosphatase
    Patent number: 8367405
    Abstract: The present invention relates to the use of tissue non-specific alkaline phosphatase (TNAP) as a marker for identifying and/or isolating adult multipotential cells. The present invention also relates to cell populations enriched by methods of the present invention and therapeutic uses of these cells.
    Type: Grant
    Filed: April 12, 2006
    Date of Patent: February 5, 2013
    Assignee: Mesoblast, Inc.
    Inventors: Stan Gronthos, Andrew Christopher William Zannettino, Paul John Simmons
  • IDENTIFYING HAEMATOPOIETIC STEM CELLS BASED ON CELL SURFACE MARKERS
    Publication number: 20110020314
    Abstract: The present invention relates to a method of identifying a haematopoietic stem cell (HSC) or progeny thereof comprising the steps of: obtaining a cell sample including HSC or progeny thereof; detecting the presence of at least one carbohydrate sequence having a sequence of at least one disaccharide repeat of glucuronic acid and N-acetylglucosamine or an equivalent thereof; and identifying a HSC or progeny thereof having the sequence or equivalent thereof. The invention also relates to methods of enriching cell populations for HSC or progeny thereof, for isolating HSC or progeny thereof and cell preparations obtained using the methods of their invention and their uses.
    Type: Application
    Filed: March 19, 2010
    Publication date: January 27, 2011
    Inventors: Susan Kaye Nilsson, Paul John Simmons, David Norman Haylock
  • Identifying haematopoietic stem cells based on cell surface markers
    Patent number: 7718379
    Abstract: The present invention relates to a method of identifying a haematopoietic stem cell (HSC) or progeny thereof comprising the steps of: obtaining a cell sample including HSC or progeny thereof; detecting the presence of at least one carbohydrate sequence having a sequence of at least one disaccharide repeat of glucuronic acid and N-acetylglucosamine or an equivalent thereof; and identifying a HSC or progeny thereof having the sequence or equivalent thereof. The invention also relates to methods of enriching cell populations for HSC or progeny thereof, for isolating HSC or progeny thereof and cell preparations obtained using the methods of their invention and their uses.
    Type: Grant
    Filed: November 1, 2007
    Date of Patent: May 18, 2010
    Assignee: The Peter Maccallum Cancer Institute
    Inventors: Susan Kaye Nilsson, Paul John Simmons, David Norman Haylock
  • Identification and isolation of somatic stem cells and uses thereof
    Patent number: 7718376
    Abstract: The present invention relates to the identification of a specific population of cell types, in particular somatic stem cells including haematopoietic stem cells, mesenchymal stem cells and keratinocyte stem cells. The invention also provides for methods of isolation and uses of the stem cells. Derived from the methods of the present invention, there is provided a method of identifying a stem cell comprising the steps of: obtaining a cell sample including stem cells; detecting the presence of angiotensin converting enzyme (ACE) or a fragment thereof on a cell; and identifying the stem cells having ACE or a fragment thereof.
    Type: Grant
    Filed: August 15, 2002
    Date of Patent: May 18, 2010
    Assignees: Peter MacCallum Cancer Institute, Medvet Science Pty Ltd.
    Inventor: Paul John Simmons
  • Isolation of adult multipotential cells by tissue non-specific alkaline phosphatase
    Publication number: 20090074728
    Abstract: The present invention relates to the use of tissue non-specific alkaline phosphatase (TNAP) as a marker for identifying and/or isolating adult multipotential cells. The present invention also relates to cell populations enriched by methods of the present invention and therapeutic uses of these cells.
    Type: Application
    Filed: April 12, 2006
    Publication date: March 19, 2009
    Inventors: Stan Gronthos, Andrew Christopher William Zannettino, Paul John Simmons
  • Methods for Stem Cell Expansion and Differentiation
    Publication number: 20080160610
    Abstract: The present invention provides methods, culture media, and apparatus to produce useful amounts of specific cell populations ex vivo by the modulation of Opn and/or an active Opn fragment. The present invention provides ex vivo expanded populations of HSC for use in transplantation therapy and in clinical and research activities, such as drug screening, toxicity testing, and other research activities. Also provided are methods, devices and culture media are provided to inhibit Opn binding to HISC to promote the increased production of more differentiated cell populations.
    Type: Application
    Filed: May 3, 2005
    Publication date: July 3, 2008
    Applicant: PETER MACCALLUM CANCER INSTITUTE
    Inventors: Susan K. Nilsson, David Norman Haylock, Paul John Simmons
  • Method of enhancing self renewal of stem cells and uses thereof
    Publication number: 20030113913
    Abstract: The present invention relates to methods for self renewal of stem cells. In particular the invention relates to stem cells of increased transplant potential or enhanced self renewal, stem cell cultures derived therefrom and uses of the stem cell cultures for treatment and particularly for transplantation and gene therapy protocols.
    Type: Application
    Filed: October 21, 2002
    Publication date: June 19, 2003
    Applicant: PETER MACCALLUM CANCER INSTITUTE
    Inventors: Louise Elizabeth Purton, David Norman Haylock, Paul John Simmons, Steven James Collins