Abstract: The present disclosure is directed to compounds of formula (I): wherein X, Y, R1, R2 and R3 are as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.

Abstract: The invention relates to screening panels such as a mineral screening panel, and related screening systems. In one aspect, the invention provides a panel suitable for engaging a supporting frame in abutment with a number of adjacent screening panels including: a screening surface with peripheral sides and screening apertures between the peripheral sides; each peripheral side having a plurality of engaging protrusions extending from the peripheral side in a direction transverse to the screening surface for engaging the supporting frame to secure the screening panel to the supporting frame; wherein the protrusions are shaped and sized to engage complementary formations on the supporting frame in a snap-fit configuration. The invention also relates to a screening system including a plurality of screening panels and a supporting frame.

Abstract: A method for operating a liquid helium cooling system of a magnetic resonance imaging system, comprises: providing a first timetable including scan times and a second timetable including a plurality of time slots associated with one of at least two different levels of electrical power availability; determining, based on the first timetable, off-times when the system is not used for scanning; determining, based on the second timetable, at least one time slot within the off-times that is not associated with the level of highest electrical power availability; activating a power-saving mode during the at least one time slot; and activating a standard operating mode of the liquifying device prior to start of the next scan time.

Abstract: A method of operating a magnetic resonance imaging (MRI) apparatus includes exciting a body coil of the MRI apparatus to emit a radio-frequency signal, determining a center frequency of a resonance curve of the body coil, and calculating a magnet target frequency based on the determined center frequency. A magnet is ramped to the magnet target frequency.

Abstract: A current lead arrangement for supplying current to a superconducting magnet coil, comprising a current lead and a cryogenic refrigerator. The current lead comprises a first section of low temperature superconductor (LTS) wire, joined to a second section of a high temperature superconductor (HTS) material, in turn joined to a third section of a resistive material. The cryogenic refrigerator comprises a first cooling stage and a second cooling stage. A lower end of the third section and an upper end of the second section are thermally linked to the first cooling stage, a lower end of the first section is thermally and electrically connected to the superconducting magnet coil.

Abstract: A current lead arrangement for supplying current to a superconducting magnet coil, comprising a current lead and a cryogenic refrigerator. The current lead comprises a first section of low temperature superconductor (LTS) wire, joined to a second section of a high temperature superconductor (HTS) material, in turn joined to a third section of a resistive material. The cryogenic refrigerator comprises a first cooling stage and a second cooling stage. A lower end of the third section and an upper end of the second section are thermally linked to the first cooling stage, a lower end of the first section is thermally and electrically connected to the superconducting magnet coil.

Abstract: Panel member assembly (10, 11, 60, 80, 100, 130) for use as a screening panel in a vibratory screening machine for treatment of mining materials either as an impact panel member or as a sieving panel member. The assembly has an engagement face (12, 105) for engagement during use with treatment material. The assembly also has a support structure (23, 102, 131) with a first side (26) directed towards the engagement face. The first side defines a plurality of spaced receiving zones (29, 129, 138) each being configured to locate an individual hard wear resistant insert (21, 101, 136, 137). The assembly also has a plurality of the inserts respectively located in a receiving zone with part of the inserts extending towards the engagement face. The support structure and located inserts are retained in a moulded cover material (24).

Abstract: The invention relates to screening panels such as a mineral screening panel, and related screening systems. In one aspect, the invention provides a panel suitable for engaging a supporting frame in abutment with a number of adjacent screening panels including: a screening surface with peripheral sides and screening apertures between the peripheral sides; each peripheral side having a plurality of engaging protrusions extending from the peripheral side in a direction transverse to the screening surface for engaging the supporting frame to secure the screening panel to the supporting frame; wherein the protrusions are shaped and sized to engage complementary formations on the supporting frame in a snap-fit configuration. The invention also relates to a screening system including a plurality of screening panels and a supporting frame.

Abstract: A method of operating a magnetic resonance imaging (MRI) apparatus includes exciting a body coil of the MRI apparatus to emit a radio-frequency signal, determining a center frequency of a resonance curve of the body coil, and calculating a magnet target frequency based on the determined center frequency. A magnet is ramped to the magnet target frequency.

Abstract: A method of operating a magnetic resonance imaging (MRI) apparatus includes exciting a body coil of the MRI apparatus to emit a radio-frequency signal, determining a center frequency of a resonance curve of the body coil, and calculating a magnet target frequency based on the determined center frequency. A magnet is ramped to the magnet target frequency.

Abstract: A method of operating a magnetic resonance imaging (MRI) apparatus includes exciting a body coil of the MRI apparatus to emit a radio-frequency signal, determining a center frequency of a resonance curve of the body coil, and calculating a magnet target frequency based on the determined center frequency. A magnet is ramped to the magnet target frequency.

Abstract: A method of operating a magnetic resonance imaging (MRI) apparatus includes exciting a body coil of the MRI apparatus to emit a radio-frequency signal, determining a center frequency of a resonance curve of the body coil, and calculating a magnet target frequency based on the determined center frequency. A magnet is ramped to the magnet target frequency.

Abstract: A calibration method for calibrating a measuring element for determining an electric current flowing through a basic-field magnet of a magnetic resonance imaging system includes performing a measurement with the measuring element, and performing a frequency measurement in the magnetic field of the basic-field magnet with a frequency measuring unit. The measurement of the measuring element and the frequency measurement are corresponding to the same magnetic field of the basic-field magnet. The calibration method also includes calculating a calibration factor based on a deviation between the measurement with the measuring element and the frequency measurement, and calibrating the measuring element or the electric current in the basic-field magnet based on the calibration factor.

Abstract: A calibration method for calibrating a measuring element for determining an electric current flowing through a basic-field magnet of a magnetic resonance imaging system includes performing a measurement with the measuring element, and performing a frequency measurement in the magnetic field of the basic-field magnet with a frequency measuring unit. The measurement of the measuring element and the frequency measurement are corresponding to the same magnetic field of the basic-field magnet. The calibration method also includes calculating a calibration factor based on a deviation between the measurement with the measuring element and the frequency measurement, and calibrating the measuring element or the electric current in the basic-field magnet based on the calibration factor.

Abstract: A fault-tolerant cryogenically cooled system including an outer vacuum chamber defining a vacuum region in its interior volume; a cryogenic refrigerator; equipment to be cooled, housed within the vacuum region; a free volume delimited within the vacuum region and containing a cryogen; a cold plate exposed to the free volume and thermally linked to the equipment to be cooled; a heat exchanger thermally linked to a coldest stage of the refrigerator and exposed to the free volume; a cryogen buffer vessel delimiting a buffer volume; and a passage linking the buffer volume with the free volume.

Abstract: An arrangement for cryogenic cooling includes a cryogen tank, a cryogenic recondensing refrigerator arranged to cool a heat exchanger that is exposed to the interior of the cryogen tank, and an arrangement for conducting heat from a cooled article to the cryogen tank. A further cryogen tank is provided below the heat exchanger and arranged to receive cryogen liquid recondensed on the heat exchanger.

Abstract: An arrangement for cryogenic cooling comprising a cryogen tank (14), a cryogenic recondensing refrigerator (12) arranged to cool a heat exchanger which is exposed to the interior of the cryogen tank (14) and an arrangement (16; 26) for conducting heat from a cooled article (10) to the cryogen tank. A further cryogen tank (20) is provided below the heat exchanger and arranged to receive cryogen liquid recondensed on the heat exchanger.

Abstract: In a method and apparatus for maintaining operation of ancillary equipment associated with a superconducting magnet carrying a DC current, the DC current is directed through a DC-to-AC converter, and the magnitude of the current flowing through the superconducting magnet is ramped down at a controlled rate, thereby generating a controlled voltage across a controlled impedance, and powering the ancillary equipment by the controlled voltage and an associated current, and the ramping rate is controlled in order to maintain a required controlled voltage.

Abstract: In a method and apparatus for maintaining operation of ancillary equipment associated with a superconducting magnet carrying a DC current, the DC current is directed through a DC-to-AC converter, and the magnitude of the current flowing through the superconducting magnet is ramped down at a controlled rate, thereby generating a controlled voltage across a controlled impedance, and powering the ancillary equipment by the controlled voltage and an associated current, and the ramping rate is controlled in order to maintain a required controlled voltage.