Patents by Inventor Paul Joseph Dominowski

Paul Joseph Dominowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adjuvant compositions
    Patent number: 11896666
    Abstract: This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
    Type: Grant
    Filed: March 8, 2021
    Date of Patent: February 13, 2024
    Assignee: Zoetis Services LLC
    Inventors: Paul Joseph Dominowski, Ramasamy Mannar Mannan, Richard Lee Krebs, James Richard Thompson, Tedd Alan Childers, Mary Kathryn Olsen, Robert John Yancey, Jr., Risini Dhammika Weeratna, Shucheng Zhang, Cedo Martin Bagi
  • Foot-and-mouth disease vaccine
    Patent number: 11865171
    Abstract: Compositions for prevention of Foot and Mouth Disease (FMD) are provided, comprising an antigen component in the amount equivalent to 0.5-20 ?g FMD virus and an adjuvant component comprising oil, an immunostimulatory oligonucleotide, and a polycationic carrier. Methods of using the composition, as well as the methods of reducing FMD persistence are also provided.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: January 9, 2024
    Assignees: Zoetis Services LLC, United States of America, as represented by the Secretary of Agriculture
    Inventors: Paul Joseph Dominowski, John Morgan Hardham, James Alan Jackson, Cyril Gerard Gay, Luis Leandro Rodriguez, Peter William Krug, Aida Elizabeth Rieder
  • OIL-BASED ADJUVANTS
    Publication number: 20240000913
    Abstract: The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.
    Type: Application
    Filed: May 16, 2023
    Publication date: January 4, 2024
    Inventors: Paul Joseph Dominowski, Dennis L. Foss, Guillermo Gallo, John Morgan Hardham, Richard Lee Krebs, Sandra Ann Marie Lightle, Suman Mahan, Sangita Mediratta, Kaori Mohr, Duncan Mwangi, Sharath K. Rai, Sarah A. Salmon, Shaunak Vora, Lauren Wilmes
  • Oil-based adjuvants
    Patent number: 11701415
    Abstract: The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.
    Type: Grant
    Filed: February 16, 2021
    Date of Patent: July 18, 2023
    Assignee: Zoetis Services LLC
    Inventors: Paul Joseph Dominowski, Dennis L. Foss, Guillermo Gallo, John Morgan Hardham, Richard Lee Krebs, Sandra Ann Marie Lightle, Suman Mahan, Sangita Mediratta, Kaori Mohr, Duncan Mwangi, Sharath K. Rai, Sarah A. Salmon, Shaunak Vora, Lauren Wilmes
  • METHODS AND COMPOSITION FOR INDUCTION OF IMMUNE RESPONSE
    Publication number: 20230100089
    Abstract: The invention provides a substantially antigen-free composition for induction of innate immune response in a bird or a mammal, the composition comprising a saponin, a sterol, a quaternary amine, and a polyacrylic polymer to the mammal or bird. Methods of using the composition are also provided.
    Type: Application
    Filed: April 28, 2022
    Publication date: March 30, 2023
    Inventors: Paul Joseph Dominowski, Duncan Mwangi, Joseph M. Bricker, Dennis L. Foss, Sharath K. Rai, Suman Mahan
  • VACCINE AGAINST INFECTIOUS BRONCHITIS
    Publication number: 20220175911
    Abstract: Poultry vaccines against infectious bronchitis and Turkey Rhinotracheitis are provided. The vaccines are adjuvanted with oil emulsion containing an immunostimulatory oligonucleotide. The methods of using the vaccines are also provided.
    Type: Application
    Filed: July 13, 2021
    Publication date: June 9, 2022
    Inventors: Carla Maria Batista de Freitas, Maria Carolina Ferreira dos Santos, Paul Joseph Dominowski, Harmen Jacob Geerligs
  • Methods and compositions for induction of immune response
    Patent number: 11318200
    Abstract: The invention provides a substantially antigen-free composition for induction of innate immune response in a bird or a mammal, the composition comprising a saponin, a sterol, a quaternary amine, and a polyacrylic polymer to the mammal or bird. Methods of using the composition are also provided.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: May 3, 2022
    Assignee: Zoetis Services LLC
    Inventors: Paul Joseph Dominowski, Duncan Mwangi, Joseph M. Bricker, Dennis L. Foss, Sharath K. Rai, Suman Mahan
  • FOOT-AND-MOUTH DISEASE VACCINE
    Publication number: 20220088173
    Abstract: Compositions for prevention of Foot and Mouth Disease (FMD) are provided, comprising an antigen component in the amount equivalent to 0.5-20 ?g FMD virus and an adjuvant component comprising oil, an immunostimulatory oligonucleotide, and a polycationic carrier. Methods of using the composition, as well as the methods of reducing FMD persistence are also provided.
    Type: Application
    Filed: February 19, 2021
    Publication date: March 24, 2022
    Inventors: Paul Joseph Dominowski, John Morgan Hardham, James Alan Jackson, Cyril Gerard Gay, Luis Leandro Rodriguez, Peter William Krug, Aida Elizabeth Rieder
  • ANTI-CORONAVIRUS VACCINES
    Publication number: 20220047696
    Abstract: The invention provides stable coronavirus spike proteins. Immunogenic compositions comprising same and the methods of using these immunogenic compositions are also provided.
    Type: Application
    Filed: July 30, 2021
    Publication date: February 17, 2022
    Inventors: Eric Todd Baima, Yulia Burakova, Paul Joseph Dominowski, Steven Alan Dunham, Nicole Lynn Hainer, John Morgan Hardham, Mahesh Kumar, Jason John Millership, Duncan M. Mwangi, Sharath K. Rai, Sharon Marie Wappel, Dennis Lee Foss
  • Novel Adjuvant Compositions
    Publication number: 20210338810
    Abstract: This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
    Type: Application
    Filed: March 8, 2021
    Publication date: November 4, 2021
    Inventors: Paul Joseph Dominowski, Ramasamy Mannar Mannan, Richard Lee Krebs, James Richard Thompson, Tedd Alan Childers, Mary Kathryn Olsen, Robert John Yancey, JR., Risini Dhammika Weeratna, Shucheng Zhang, Cedo Martin Bagi
  • Vaccine against infectious bronchitis
    Patent number: 11103573
    Abstract: Poultry vaccines against infectious bronchitis and Turkey Rhinotracheitis are provided. The vaccines are adjuvanted with oil emulsion containing an immunostimulatory oligonucleotide. The methods of using the vaccines are also provided.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: August 31, 2021
    Assignee: Zoetis Services LLC
    Inventors: Carla Maria Batista de Freitas, Maria Carolina Ferreira dos Santos, Paul Joseph Dominowski, Harmen Jacob Geerligs
  • OIL-BASED ADJUVANTS
    Publication number: 20210170013
    Abstract: The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.
    Type: Application
    Filed: February 16, 2021
    Publication date: June 10, 2021
    Inventors: Paul Joseph Dominowski, Dennis L. Foss, Guillermo Gallo, John Morgan Hardham, Richard Lee Krebs, Sandra Ann Marie Lightle, Suman Mahan, Sangita Mediratta, Kaori Mohr, Duncan Mwangi, Sharath K. Rai, Sarah A. Salmon, Shaunak Vora, Lauren Wilmes
  • Foot-and-mouth disease vaccine
    Patent number: 10967058
    Abstract: Compositions for prevention of Foot and Mouth Disease (FMD) are provided, comprising an antigen component in the amount equivalent to 0.5-20 ?g FMD virus and an adjuvant component comprising oil, an immunostimulatory oligonucleotide, and a polycationic carrier. Methods of using the composition, as well as the methods of reducing FMD persistence are also provided.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: April 6, 2021
    Assignees: Zoetis Services LLC, United States of America, as represented by the Secretary of Agriculture
    Inventors: Paul Joseph Dominowski, John Morgan Hardham, James Alan Jackson, Cyril Gerard Gay, Luis Leandro Rodriguez, Peter William Krug, Aida Elizabeth Rieder
  • Oil-based adjuvants
    Patent number: 10953080
    Abstract: The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: March 23, 2021
    Assignee: Zoetis Services LLC
    Inventors: Paul Joseph Dominowski, Dennis L. Foss, Guillermo Gallo, John Morgan Hardham, Richard Lee Krebs, Sandra Ann Marie Lightle, Suman Mahan, Sangita Mediratta, Kaori Mohr, Duncan Mwangi, Sharath K. Rai, Sarah A. Salmon, Shaunak Vora, Lauren Wilmes
  • Adjuvant compositions
    Patent number: 10940202
    Abstract: This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: March 9, 2021
    Assignee: Zoetis Services LLC
    Inventors: Paul Joseph Dominowski, Ramasamy Mannar Mannan, Richard Lee Krebs, James Richard Thompson, Tedd Alan Childers, Mary Kathryn Olsen, Robert John Yancey, Jr., Risini Dhammika Weeratna, Shucheng Zhang, Cedo Martin Bagi
  • VACCINES AGAINST HENDRA AND NIPAH VIRUS INFECTION
    Publication number: 20210008195
    Abstract: Disclosed is a method of protecting an animal in need thereof from Hendra or Nipah virus infection comprising administering to said animal a single dose of a vaccine, the vaccine comprising:an antigen component comprising a Hendra antigen or a Nipah antigen; and an adjuvant comprising oil, polycationic carrier and a CpG containing immunostimulatory oligonucleotide, wherein the vaccine is a W/O emulsion.
    Type: Application
    Filed: December 18, 2018
    Publication date: January 14, 2021
    Inventors: Paul Joseph Dominowski, Duncan M. Mwangi, Dennis Lee Foss, Sharath K. Rai, John Morgan Hardham
  • FOOT-AND-MOUTH DISEASE VACCINE
    Publication number: 20200078456
    Abstract: Compositions for prevention of Foot and Mouth Disease (FMD) are provided, comprising an antigen component in the amount equivalent to 0.5-20 ?g FMD virus and an adjuvant component comprising oil, an immunostimulatory oligonucleotide, and a polycationic carrier. Methods of using the composition, as well as the methods of reducing FMD persistence are also provided.
    Type: Application
    Filed: April 3, 2019
    Publication date: March 12, 2020
    Inventors: Paul Joseph Dominowski, John Morgan Hardham, James Alan Jackson, Cyril Gerard Gay, Luis Leandro Rodriguez, Peter William Krug, Aida Elizabeth Rieder
  • Foot-and-mouth disease vaccine
    Patent number: 10478487
    Abstract: Compositions for prevention of Foot and Mouth Disease (FM D) are provided, comprising an antigen component in the amount equivalent to 0.5-20 ?g FM D virus and an adjuvant component comprising oil, an immunostimulatory oligonucleotide, and a polycationic carrier. Methods of using the composition, as well as the methods of reducing FM D persistence are also provided.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: November 19, 2019
    Assignees: Zoetis Services LLC, United States of America, as represented by the Secretary of Agriculture
    Inventors: Paul Joseph Dominowski, John Morgan Hardham, James Alan Jackson, Cyril Gerard Gay, Luis Leandro Rodriguez, Peter William Krug, Aida Elizabeth Rieder
  • Liposomal adjuvant compositions
    Patent number: 10456459
    Abstract: The invention provides a liposomal adjuvant composition comprising an external membrane and an internal compartment, the external membrane comprising: a quaternary ammonium compound; a sterol; a phospholipid; and a glycolipid. Vaccine compositions comprising the liposomal adjuvant of the instant invention are also provided.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: October 29, 2019
    Assignee: Zoetis Services LLC
    Inventors: Paul Joseph Dominowski, Duncan Mwangi, Sharath K. Rai, Dennis L. Foss, Traci K. Godbee, Laurel Mary Sly, Suman Mahan, Shaunak Vora
  • VACCINE AGAINST INFECTIOUS BRONCHITIS
    Publication number: 20190240315
    Abstract: Poultry vaccines against infectious bronchitis and Turkey Rhinotracheitis are provided. The vaccines are adjuvanted with oil emulsion containing an immunostimulatory oligonucleotide. The methods of using the vaccines are also provided.
    Type: Application
    Filed: May 31, 2017
    Publication date: August 8, 2019
    Inventors: Carla Maria Batista de Freitas, Maria Carolina Ferreira dos Santos, Paul Joseph Dominowski, Harmen Jacob Geerligs