Patents by Inventor Paul Jurek

Paul Jurek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of cancer cells overexpressing somatostatin receptors using ocreotide derivatives chelated to radioisotopes
    Patent number: 11541133
    Abstract: A cancer targeting composition, kit, and method for treatment of cancer cells overexpressing somatostatin receptors is disclosed. The composition includes a radioisotope, a chelator, and a targeting moiety. The chelator includes a nitrogen ring structure including a tetraazacyclododecane, a triazacyclononane, and/or a tetraazabicyclo [6.6.2] hexadecane derivative. The targeting moiety includes a somatostatin receptor targeting peptide. The somatostatin receptor targeting peptide includes an octreotide derivative. The targeting moiety is chelated to the radioisotope by the chelator whereby the cancer cells are targeted for elimination.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: January 3, 2023
    Assignees: RADIOMEDIXINC., ORANO MED
    Inventors: Izabela Tworowska, Nilesh Wagh, Ebrahim S. Delpassand, Federico Rojas-Quijano, Paul Jurek, Garry E. Kiefer, Tania A. Stallons, Amal Saidi, Julien Torgue
  • ANTIBODIES FOR CHELATED RADIONUCLIDES AND CLEARING AGENTS
    Publication number: 20220031871
    Abstract: The present application relates to antibodies which bind specifically to chelated radionuclides, including bispecific antibodies, It further relates to the use of such bispecific antibodies in applications such as radioimmunoimaging and radioimmunotherapy. It additionally relates to clearing agents and useful in such methods.
    Type: Application
    Filed: April 16, 2019
    Publication date: February 3, 2022
    Applicants: Hoffmann-La Roche Inc., Orano Med SAS
    Inventors: Julien TORGUE, Paul JUREK, Federico ROJAS-QUIJANO, Garry E. KIEFER, Olivier FREYTAG, Christian GERDES, Christian KLEIN, Pablo UMANA, Alexander HAAS, Sofia FROST, Amal SAIDI, Tapan NAYAK
  • TREATMENT OF CANCER CELLS OVEREXPRESSING SOMATOSTATIN RECEPTORS USING OCREOTIDE DERIVATIVES CHELATED TO RADIOISOTOPES
    Publication number: 20190336623
    Abstract: A cancer targeting composition, kit, and method for treatment of cancer cells overexpressing somatostatin receptors is disclosed. The composition includes a radioisotope, a chelator, and a targeting moiety. The chelator includes a nitrogen ring structure including a tetraazacyclododecane, a triazacyclononane, and/or a tetraazabicyclo [6.6.2] hexadecane derivative. The targeting moiety includes a somatostatin receptor targeting peptide. The somatostatin receptor targeting peptide includes an octreotide derivative. The targeting moiety is chelated to the radioisotope by the chelator whereby the cancer cells are targeted for elimination.
    Type: Application
    Filed: January 12, 2018
    Publication date: November 7, 2019
    Inventors: Izabela TWOROWSKA, Nilesh WAGH, Ebrahim S. DELPASSAND, Federico ROJAS-QUIJANO, Paul JUREK, Garry E. KIEFER, Tania A. STALLONS, Amal SAIDI, Julien TORGUE
  • PROCESS FOR CHELATING COPPER IONS USING CB-TE2A BIFUNCTIONAL CHELATE
    Publication number: 20120095185
    Abstract: An isolated conformational isomer of a bifunctional chelating agent of the formula (I): wherein the variables Q1 and Q2 are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a stable or radioactive metal; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate.
    Type: Application
    Filed: September 20, 2011
    Publication date: April 19, 2012
    Applicant: NORDION (CANADA) INC.
    Inventors: Garry E. KIEFER, Cara L. Ferreira, Paul Jurek
  • Method of applying time offset chromatic dispersion, dispersive optical apparatus, and an optical fiber transmission system using the apparatus
    Patent number: 5497260
    Abstract: Apparatus of the invention includes:a diffraction grating for angularly separating the spectrum components of a beam to be processed;a grating that is conjugate with the other grating, and that makes the components parallel again; anda stair-shaped mirror for reflecting the components back to the same gratings while imposing different path lengths on the respective components.The invention is particularly applicable to compensating for the dispersion of a line fiber in a very long link between a transmitter and a receiver.
    Type: Grant
    Filed: June 15, 1994
    Date of Patent: March 5, 1996
    Assignee: Alcatel N.V.
    Inventors: Marie-Paule Jurek, Jean-Jacques Bernard, Jose/ Chesnoy