Patents by Inventor Paul Karl Horan

Paul Karl Horan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced sensitivity of a cantilever sensor via specific bindings
    Patent number: 7892759
    Abstract: Detection of miniscule amounts of an analyte is accomplished via multiple bindings of specific materials on a sensor configured to sense mass. The sensor is prepared by immobilizing an antibody to a surface of the sensor, wherein the antibody is known to bind to the analyte. The prepared sensor is exposed to the analyte. The analyte binds to the antibody. The sensor then is exposed to additional antibody, which binds to the analyte. The sensor then can be sequentially exposed to additional antibodies that are known to bind to previously bound antibodies. Each additional binding further increases the effective mass of accumulated material on the sensor. The total effective mass is greater than the mass of the accumulated analyte, thus providing means for detecting extremely minute amounts of analyte. Applications include detection of pathogens and DNA.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: February 22, 2011
    Assignees: Drexel University, Leversense, LLC
    Inventors: Rajakkannu Mutharasan, David R. Maraldo, Kishan Rijal, Gossett Augustus Campbell, Paul Karl Horan
  • ENHANCED SENSITIVITY OF A CANTILEVER SENSOR VIA SPECIFIC BINDINGS
    Publication number: 20090053709
    Abstract: Detection of miniscule amounts of an analyte is accomplished via multiple bindings of specific materials on a sensor configured to sense mass. The sensor is prepared by immobilizing an antibody to a surface of the sensor, wherein the antibody is known to bind to the analyte. The prepared sensor is exposed to the analyte. The analyte binds to the antibody. The sensor then is exposed to additional antibody, which binds to the analyte. The sensor then can be sequentially exposed to additional antibodies that are known to bind to previously bound antibodies. Each additional binding further increases the effective mass of accumulated material on the sensor. The total effective mass is greater than the mass of the accumulated analyte, thus providing means for detecting extremely minute amounts of analyte. Applications include detection of pathogens and DNA.
    Type: Application
    Filed: February 15, 2008
    Publication date: February 26, 2009
    Applicant: Drexel University
    Inventors: Rajakkannu Mutharasan, David R. Maraldo, Kishan Rijal, Gossett Augustus Campbell, Paul Karl Horan
  • Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles
    Patent number: 5665328
    Abstract: Compounds, compositions, their methods of preparation and use in binding bio-affecting substances to the surface membrane of bioparticles, such as enkaryotic cells, without producing appreciable detrimental effect on morphology or physiological function of cells.
    Type: Grant
    Filed: December 1, 1992
    Date of Patent: September 9, 1997
    Assignee: Phanos Technologies, Inc.
    Inventors: Paul Karl Horan, Sue Ellen Slezak, Bruce D. Jensen