Abstract: The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.

Abstract: A system for encouraging patient stillness during an imaging scan is provided. The system includes an electronic device configured to generate a graphical representation for a patient undergoing the imaging scan. The system also includes a motion detection system configured to detect motion of the patient undergoing the imaging scan. The system further includes a computer system in communication with the electronic device and the motion detection system, wherein the computer system includes processing circuitry configured to receive a first signal from the motion detection system indicating motion of the patient undergoing the imaging scan and to send a second signal to the electronic device, in response to the first signal, to cause the electronic device to adversely modify the display of the graphical representation.

Abstract: A system for encouraging patient stillness during an imaging scan is provided. The system includes an electronic device configured to generate a graphical representation for a patient undergoing the imaging scan. The system also includes a motion detection system configured to detect motion of the patient undergoing the imaging scan. The system further includes a computer system in communication with the electronic device and the motion detection system, wherein the computer system includes processing circuitry configured to receive a first signal from the motion detection system indicating motion of the patient undergoing the imaging scan and to send a second signal to the electronic device, in response to the first signal, to cause the electronic device to adversely modify the display of the graphical representation.

Abstract: The present invention relates to a process for preparing a diol of the formulae (Ia) or (Ib), or a mixture thereof, comprising the reaction of an epoxy alcohol of formulae (Va) or (Vb), or a mixture thereof, with alkali metal borohydride or earth alkaline borohydride, in particular sodium borohydride, and anhydrous aluminum(III) chloride. The invention also relates to processes and intermediates for preparing an epoxy alcohol of formulae (Va) or (Vb). The invention furthermore relates to processes for preparing cis-metconazole in which a diol of the formulae (Ia) or (Ib) is applied as a precursor.

Abstract: Methods and apparatuses for generating hyperpolarized materials are disclosed. In one embodiment, a flexible fluid path is provided for use in a polarizer system. In a further embodiment, a polarizer system is provided with an electromechanical assembly for controlling the movement of a fluid path, when present, within a sample path of the polarizer system. In a further embodiment, a polarizer system is provided having a sample path entry point at a convenient height for use by a user standing on the ground.

Abstract: A medical imaging system includes a gantry having a bore extending therethrough, a bore cover disposed within the bore, and an element disposed on the bore cover, the element being viewable by a patient positioned within the bore to reduce patient motion. A method of imaging a patient is also described herein.

Abstract: In one embodiment, an interventional guidance method includes generating an ultrasound image of a subject anatomy of interest. The method also includes superimposing on the ultrasound image a visual indication of at least one of projection of a position of an interventional device, trajectory of the interventional device, and a location at which the interventional device will intercept an ultrasound imaging plane. The interventional guidance method also includes dynamically altering an aspect of the superimposed visual indication during a interventional procedure. The dynamic altering includes altering a dynamic indication of a trajectory of the interventional instrument transverse to the imaging plane or an interception location of the trajectory of the interventional instrument with the imaging plane.

Abstract: A profile extrusion method utilizes a specific poly(arylene ether)/polystyrene composition with little or no unhydrogenated poly(conjugated diene) rubber. The method substantially reduces the amount of die lip build-up during continuous profile extrusion for eight hours or more. Reduction of die lip build-up in turn improves the structural integrity and aesthetic properties of the extruded article.

Abstract: Methods and systems for interacting with datasets for display are provided. One method includes displaying information on a display having a surface viewable by a user and receiving a user input at a surface of a multi-touch sensitive device. The surface of the multi-touch sensitive device is a different surface than the surface of the display viewable by the user. The method further includes manipulating the displayed information in response to the received user input.

Abstract: Methods and apparatuses for generating hyperpolarized materials are disclosed. In one embodiment, a flexible fluid path is provided for use in a polarizer system. In a further embodiment, a polarizer system is provided with an electromechanical assembly for controlling the movement of a fluid path, when present, within a sample path of the polarizer system. In a further embodiment, a polarizer system is provided having a sample path entry point at a convenient height for use by a user standing on the ground.

Abstract: Methods and apparatus to enhance healthcare information analyses are disclosed herein.

Abstract: A profile extrusion method utilizes a specific poly(arylene ether)/polystyrene composition with little or no unhydrogenated poly(conjugated diene) rubber. The method substantially reduces the amount of die lip build-up during continuous profile extrusion for eight hours or more. Reduction of die lip build-up in turn improves the structural integrity and aesthetic properties of the extruded article.

Abstract: Excellent physical properties and reduced dust formation are exhibited by thermoplastic compositions comprising a poly(arylene ether); a polystyrene; a metal hydroxide; and optionally, a rubber material. The thermoplastic compositions are particularly useful for molding automobile interior parts.