Abstract: Described herein is a method for identifying an aberrant feature on a nucleic acid array. In general terms, the method comprises: a) obtaining a log transformed normalized value indicating the amount of hybridization of a test sample to a first feature on the nucleic acid array; b) calculating a z-score for the first feature using: the log transformed normalized value; and the distribution of reference log transformed normalized values that indicate the amount of hybridization of control samples to the same feature on a plurality of reference arrays; and c) identifying the test feature as aberrant if it has a z-score that is above or below a defined threshold.

Abstract: Described herein is a method for identifying an aberrant feature on a nucleic acid array. In general terms, the method comprises: a) obtaining a log transformed normalized value indicating the amount of hybridization of a test sample to a first feature on the nucleic acid array; b) calculating a z-score for the first feature using: the log transformed normalized value; and the distribution of reference log transformed normalized values that indicate the amount of hybridization of control samples to the same feature on a plurality of reference arrays; and c) identifying said test feature as aberrant if it has a z-score that is above or below a defined threshold.

Abstract: A method for microarray analysis of a sample for a target nucleic acid sequence including selecting a microarray comprising a set of oligonucleotide probes, contacting the set of oligonucleotide probes with a sample suspected of containing a target nucleic acid sequence under hybridization conditions to form a set of probe-target hybrids, contacting the set of probe-target hybrids with one or more single-stranded nucleases, removing the target nucleic acids from the remaining set of probe-target hybrids to expose the oligonucleotide probes remaining on the microarray, and labeling the remaining oligonucleotide probes, and analyzing the microarray for oligonucleotide probes hybridized to the target nucleic acid sequences.