Patents by Inventor Paul Ko
Paul Ko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12105896Abstract: A computer mouse module comprising a power supply component; a movement sensor, an encoder operable to encode data collected by the movement sensor, a transmitter for transmitting the encoded data to a computer and a physical connector for detachably attaching a handle portion to the computer mouse module. The computer mouse module may be attached to the handle portion to form a functioning mouse where a user grips the mouse handle portion to control the mouse.Type: GrantFiled: September 29, 2020Date of Patent: October 1, 2024Assignee: Microsoft Technology Licensing, LLC.Inventors: John Franciscus Marie Helmes, Paul Kos, Nicholas Yen-Cherng Chen, Michael Hall, Stephen Edward Hodges, James Alexander Devine, Qing Feng, Masaaki Fukumoto
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Patent number: 11934589Abstract: A method and apparatus for configuring a mouse device (102) through pressure detection, and further proposes a corresponding mouse device (102). Pressure detected between the mouse device (102) and an operation surface (104) may be obtained. An operating state corresponding to the pressure may be determined. The mouse device (102) may be configured to the operating state.Type: GrantFiled: October 10, 2019Date of Patent: March 19, 2024Assignee: Microsoft Technology Licensing, LLCInventors: Masaaki Fukumoto, Hao Zhuang, Jianjun Ju, Paul Kos, Nicolas Schmitt
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Publication number: 20240027441Abstract: The present disclosure relates to a lateral flow test device for performing a lateral flow test on a liquid sample, comprising: a test strip which comprises: a nitrocellulose membrane having a first capturing reagent disposed on a first surface along a test line, the first capturing reagent being configured to capture a first analyte in the liquid sample; a sample pad disposed at a first end of the nitrocellulose membrane configured to receive the liquid sample; a labelling reagent comprising a plurality of label molecules disposed on the first surface at a position between the sample pad and the test line, the label molecules being configured to bind to the first analyte; and an electrode array disposed over the nitrocellulose membrane configured to apply an electric potential across the first surface.Type: ApplicationFiled: March 2, 2022Publication date: January 25, 2024Inventors: Benjamin James Edwards, Despina Moschou, Paul Ko Ferrigno, Pedro Estrela, Sarah May Olivia Chapman, Uro{hacek over (s)} Zupancic
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Patent number: 11789551Abstract: A method, an apparatus and a corresponding electronic device for dynamically providing perceptible feedback for a rotary control component of an electronic device are provided. An operation on the rotary control component is detected. An initial value of the rotary control component is synchronized with a software control value of the electronic device. A variation value corresponding to the operation is identified. It is determined that the initial value and the variation value meet a feedback condition. Perceptible feedback is provided through a feedback component of the electronic device.Type: GrantFiled: September 10, 2019Date of Patent: October 17, 2023Assignee: Microsoft Technology Licensing, LLCInventors: Paul Kos, Masaaki Fukumoto, Siyuan Ma
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Patent number: 11238352Abstract: Techniques are provided for predicting talent flow to and/or from a geographical region. In one technique, multiple entity profiles are stored and analyzed to generate training data that is labeled indicating whether a corresponding entity has moved to or moved from a region. A machine-learned prediction model is generated or trained based on the training data. Using the machine-learned prediction model, a prediction is made whether, for each entity corresponding to another entity profile, that entity will move to or move from a particular geographic region. Based on multiple predictions, a number of entities that are predicted to move to or move from the particular geographic region is determined. Talent flow data that is based on the number of entities is presented on a computer display.Type: GrantFiled: March 30, 2018Date of Patent: February 1, 2022Assignee: Microsoft Technology Licensing, LLCInventors: Chi-Yi Kuan, Shen Huang, Yu Wang, Yongzheng Zhang, Paul Ko, Shady Elasra, Fanbin Bu
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Publication number: 20190303773Abstract: Techniques are provided for predicting talent flow to and/or from a geographical region. In one technique, multiple entity profiles are stored and analyzed to generate training data that is labeled indicating whether a corresponding entity has moved to or moved from a region. A machine-learned prediction model is generated or trained based on the training data. Using the machine-learned prediction model, a prediction is made whether, for each entity corresponding to another entity profile, that entity will move to or move from a particular geographic region. Based on multiple predictions, a number of entities that are predicted to move to or move from the particular geographic region is determined. Talent flow data that is based on the number of entities is presented on a computer display.Type: ApplicationFiled: March 30, 2018Publication date: October 3, 2019Inventors: Chi-Yi Kuan, Shen Huang, Yu Wang, Yongzheng Zhang, Paul Ko, Shady Elasra, Fanbin Bu
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Publication number: 20170308913Abstract: Techniques are provided for displaying information about entities in a social network. An analysis of profiles of multiple representatives is performed. Each representative is registered with a social network provider and represents an organization from multiple organizations. Based on the analysis, the organizations are ranked. Data about a subset of the organizations is presented, based on the ranking, through a user interface. A user selects an indicator that is associated with a particular organization of the multiple organizations. In response to the input, a subset of the representatives is identified. One or more scores that were generated for a particular representative in the subset are determined. Data about the subset of the representatives is caused to be presented through the user interface. The data identifies the one or more scores and associates the one or more scores with the particular representative.Type: ApplicationFiled: April 21, 2016Publication date: October 26, 2017Inventors: John Chao, Derek Koh, Paul Ko, Lindsey Bly, Wenjing Zhang, Clay Blanchard, Carson Moore, Michael Derezin
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Patent number: 9494583Abstract: The disclosure relates to a method of detecting a structural change in a molecule that is attached to a surface that is electrically conductive, wherein the method includes monitoring the phase of the electrochemical impedance at the surface, and wherein a change in the phase indicates a change in the structure of the molecule. The disclosure also relates to arrays and methods for making arrays having molecules, such as polypeptides, attached to electrically conductive surfaces, such as electrodes.Type: GrantFiled: September 28, 2012Date of Patent: November 15, 2016Assignee: UNIVERSITY OF LEEDSInventors: Paul Ko Ferrigno, Christoph Walti, David Evans, Steven Johnson, Alexander Giles Davies
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Patent number: 9447170Abstract: The invention provides novel scaffold proteins for the display of peptides such as peptide aptamers. The novel scaffold proteins are modifications of Stefin A or STM (a variant of Stefin A) and are useful as scaffold proteins and as display systems.Type: GrantFiled: September 5, 2014Date of Patent: September 20, 2016Assignee: Avacta Life Sciences LimitedInventors: Paul Ko Ferrigno, Elisenda Gendra
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Publication number: 20160024184Abstract: The invention provides novel scaffold proteins for the display of peptides such as peptide aptamers. The novel scaffold proteins are modifications of Stefin A or STM (a variant of Stefin A) and are useful as scaffold proteins and as display systems.Type: ApplicationFiled: September 5, 2014Publication date: January 28, 2016Inventors: Paul Ko Ferrigno, Elisenda Gendra
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Publication number: 20150120680Abstract: One or more techniques and/or systems are provided for providing a discussion summary corresponding to a search query and/or for providing discussion session search results. For example, discussion data (e.g., corresponding to real-time messaging, such as a microblog discussion) may be evaluated to identify a discussion topic for a discussion sessions (e.g., a kitchen renovation topic may be assigned to a 1 hour exchange of kitchen renovation messages by a discussion group). A discussion summary of a discussion session may be provided based upon the discussion session having a discussion topic corresponding to a search query topic of a search query. The discussion summary may be provided along with other results for the query and may describe the discussion group, identifiers such as hashtags used by the discussion group, meeting dates/times, average number(s) of participants, other discussion sessions hosted by the discussion group, future discussion sessions, and/or other information.Type: ApplicationFiled: October 24, 2013Publication date: April 30, 2015Applicant: Microsoft CorporationInventors: Omar Alonso, Kartikay Khandelwal, Mohamed Mansour, Paul Ko, Nina Mishra, Krishnaram Kenthapadi, Abhimanyu Das
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Patent number: 8853131Abstract: The invention provides novel scaffold proteins for the display of peptides such as peptide aptamers. The novel scaffold proteins are modifications of Stefin A or STM (a variant of Stefin A) and are useful as scaffold proteins and as display systems.Type: GrantFiled: April 16, 2009Date of Patent: October 7, 2014Assignee: Aptuscan LimitedInventors: Paul Ko Ferrigno, Elisenda Gendra
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Patent number: 8481491Abstract: The present invention relates to the use of Stefin A as a scaffold protein for the display of inserted peptides, particularly wherein the Stefin A is a human Stefin A. Several mutations are advantageously made in the wild type stefin A sequence to improve it as a scaffold; preferably the Stefin A comprises a heterologous peptide insertion at the Leu 73 site. Furthermore, preferably the scaffold protein comprises a V48D mutation; preferably the scaffold protein comprises a G4W mutation. Preferably the scaffold comprises Leu73, V48D and G4W mutations. The invention also relates to the scaffold proteins themselves, in particular a stefin A polypeptide having the Leu73, V48D and G4W mutations, such as shown as SEQ ID NO: 1. The invention also relates to a method for identifying binding proteins and to peptide A (RLNKPLPSLPV, SEQ ID NO: 30) and its use in treating yeast infections.Type: GrantFiled: September 23, 2011Date of Patent: July 9, 2013Assignee: Medical Research CouncilInventors: Robbie Woodman, Johannes Tsung-Han Yeh, Sophie Laurenson, Paul Ko Ferrigno
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Publication number: 20120190819Abstract: The present invention relates to the use of Stefin A as a scaffold protein for the display of inserted peptides, particularly wherein the Stefin A is a human Stefin A. Several mutations are advantageously made in the wild type stefin A sequence to improve it as a scaffold; preferably the Stefin A comprises a heterologous peptide insertion at the Leu 73 site. Furthermore, preferably the scaffold protein comprises a V48D mutation; preferably the scaffold protein comprises a G4W mutation. Preferably the scaffold comprises Leu73, V48D and G4W mutations. The invention also relates to the scaffold proteins themselves, in particular a stefin A polypeptide having the Leu73, V48D and G4W mutations, such as shown as SEQ ID NO: 1. The invention also relates to a method for identifying binding proteins and to peptide A (RLNKPLPSLPV) and its use in treating yeast infections.Type: ApplicationFiled: September 23, 2011Publication date: July 26, 2012Applicant: MEDICAL RESEARCH COUNCILInventors: Robbie Woodman, Johannes Tsung-Han Yeh, Sophie Laurenson, Paul Ko Ferrigno
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Patent number: 8063019Abstract: The present invention relates to the use of Stefin A as a scaffold protein for the display of inserted peptides, particularly wherein the Stefin A is a human Stefin A. Several mutations are advantageously made in the wild type stefin A sequence to improve it as a scaffold; preferably the Stefin A comprises a heterologous peptide insertion at the Leu 73 site. Furthermore, preferably the scaffold protein comprises a V48D mutation; preferably the scaffold protein comprises a G4W mutation. Preferably the scaffold comprises Leu73, V48D and G4W mutations. The invention also relates to the scaffold proteins themselves, in particular a stefin A polypeptide having the Leu73, V48D and G4W mutations, such as shown as SEQ ID NO: 1. The invention also relates to a method for identifying binding proteins and to peptide A (RLNKPLPSLPV) and its use in treating yeast infections.Type: GrantFiled: June 8, 2006Date of Patent: November 22, 2011Assignee: Medical Research CouncilInventors: Robbie Woodman, Johannes Tsung-Han Yeh, Sophie Laurenson, Paul Ko Ferrigno
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Publication number: 20110053796Abstract: The invention provides novel scaffold proteins for the display of peptides such as peptide aptamers. The novel scaffold proteins are modifications of Stefin A or STM (a variant of Stefin A) and are useful as scaffold proteins and as display systems.Type: ApplicationFiled: April 16, 2009Publication date: March 3, 2011Inventors: Paul Ko Ferrigno, Elisenda Gendra
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Publication number: 20100234234Abstract: The invention relates to a method of detecting a structural change in a molecule, said molecule being attached to a surface, said surface being electrically conductive, wherein the phase of the electrochemical impedance at said surface is monitored, and wherein a change in the phase in the electrochemical impedance at said surface indicates a change in the structure of said molecule. The invention further relates to methods for making arrays having molecules such as, polypeptides attached to electrically conductive surfaces such as electrodes, and to arrays.Type: ApplicationFiled: September 13, 2007Publication date: September 16, 2010Applicants: UNIVERSITY OF LEEDS, MEDICAL RESEARCH COUNCILInventors: Paul Ko Ferrigno, Christoph Walti, David Evans, Steven Johnson, Alexander Giles Davies
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Publication number: 20080207509Abstract: The present invention relates to the use of Stefin A as a scaffold protein for the display of inserted peptides, particularly wherein the Stefin A is a human Stefin A. Several mutations are advantageously made in the wild type stefin A sequence to improve it as a scaffold; preferably the Stefin A comprises a heterologous peptide insertion at the Leu 73 site. Furthermore, preferably the scaffold protein comprises a V48D mutation; preferably the scaffold protein comprises a G4W mutation. Preferably the scaffold comprises Leu73, V48D and G4W mutations. The invention also relates to the scaffold proteins themselves, in particular a stefin A polypeptide having the Leu73, V48D and G4W mutations, such as shown as SEQ ID NO: 1. The invention also relates to a method for identifying binding proteins and to peptide A (RLNKPLPSLPV) and its use in treating yeast infections.Type: ApplicationFiled: June 8, 2006Publication date: August 28, 2008Applicant: MEDICAL RESEARCH COUNCILInventors: Robbie Woodman, Johannes Tsung-Hau Yeh, Sophie Laurenson, Paul Ko Ferrigno