Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: In various embodiments method are provided for generating expression cassettes and gene therapy vectors comprising those cassettes that recapitulate the spatiotemporal pattern of expression of the endogenous gene. In certain embodiments the methods comprise (i) selecting a target gene; (ii) identifying putative regulatory elements associated with the target gene; (iii) determining if the regulatory element is a key regulatory element and (iv) providing a list of the key regulatory elements identified in step (iii).

Abstract: An articulated pendulum steering system for an articulated vehicle having a front vehicle section and a rear vehicle section, the system including a vertical bearing pin supported by at least one movable joint support, and a movable joint pin supported by at least one movable joint support, wherein the vertical bearing pin and the movable joint pin sit in an articulated pendulum joint axle.

Abstract: Optoelectronic probe cards, methods of fabrication, and methods of use, are disclosed. Briefly described, one exemplary embodiment includes an optoelectronic probe card adapted to test an electrical quality and an optical quality of an optoelectronic structure under test having electrical and optical components.

Abstract: Articulated pendulum steering for construction vehicles, in particular, for wheeled loaders which connects the front vehicle section (6) to the back vehicle section (7) in such a way that both the operator controlled steering motion and a pendulum motion between both vehicle sections (6, 7) occur. Basically, the articulated pendulum steering consists of a vertical bearing pin (2) and an almost horizontally arranged movable joint pin (8). On the vertical pin (2) a bearing ring (3′, 3″) sits both in the upper and in the lower area that is held in place by cup shaped supports (4′, 4″) which each are fitted onto one of two arms (5′, 5″) on the front vehicle section (6). Both arms (5′, 5″) extend into fork-like structural openings of the articulated pendulum joint (1). On the rearward front side of the movable joint pin (8) an extension pin (16) is fitted on which another bearing ring (9) sits.

Abstract: A wheeled building and constructional machine of the mechanical shovel, bulldozer or the like type has an articulated steering system and comprises a vehicle chassis, a plurality of wheel axles, a hydraulic suspension system for the wheel axles, and at least one transversely stabilizing valve. The hydraulic suspension system comprises a plurality of fluid cylinders which are disposed between pivoting levers which are rotatably mounted and hold the wheel axles, and the vehicle chassis, and rotatably mounted on these vehicle parts. The fluid cylinders are adapted for action upon both of sides and are connected to the stabilizing valve or valves.