Patents by Inventor Paul Kong Thoo Lin

Paul Kong Thoo Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8350036
    Abstract: The present invention relates to chemical compounds with anti-cancer and anti-parasite activity. The invention relates, above all, to novel bisnaphthalimidopropyl derivatives with specific cytotoxic activity towards human cancer cells and protozoan cells capable of causing parasitic diseases in humans. The invention further relates to chemical compounds to be administered especially to humans and in particular for therapeutic use.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: January 8, 2013
    Assignee: Universidade Do Porto
    Inventors: Anabela Cordeiro Da Silva, Joana Alexandra Pinto Da Costa Tavares, Paul Kong Thoo Lin
  • Publication number: 20120238487
    Abstract: A polymer having a structure according to the following formula (I): wherein: A represents a hydrophilic group; B represents a hydrophobic aromatic group such as 5-dimethylamino-1-naphthalenesulfonyl (Dansyl), 9-fluorenylmethoxy carbonyl (Fmoc) and naphthalene (Naphth); D and E independently represent amine groups; F represents an amine group, the amine group being substituted with a B group and an A group, or the amine group being a quaternary ammonium moiety; wherein W, X, Y and Z each independently have values greater than or equal to (1), especially in the range of (1) to (10).
    Type: Application
    Filed: September 6, 2010
    Publication date: September 20, 2012
    Applicant: ROBERT GORDON UNIVERSITY
    Inventors: Paul Kong Thoo Lin, Woei Ping Cheng, Clare Hoskins
  • Publication number: 20100151508
    Abstract: Flavonoid-type compounds of the Formula (II); in which R1 is alkyl C2 to C20, R2, R3, R4 and R5 are any one or more of hydrogen, alkyl, alkenyl, alkynyl, phenyl or benzyl, especially 7-decyl-3-hydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopy-ran-4-one or 7-ethyl-3-hydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one provide fluorescent probes and antioxidants, and are useful in discriminating healthy and stressed cells.
    Type: Application
    Filed: November 21, 2007
    Publication date: June 17, 2010
    Applicant: THE ROBERT GORDON UNIVERSITY
    Inventors: Paul Kong Thoo Lin, Charles Stuart Bestwick
  • Publication number: 20090062329
    Abstract: The bisnaphthalimidopropyl derivatives with anti-parasitic and anti-cancer activity. Bisnaphthalimidopropyl derivatives (A) BNIPPut, BNIPDapen, BNIPDhex, BNIPDahep, BNIPDaoct, BNIPDanon, BNTPDadec, BNIPDadod, BNPDpta, BNIPDeta were synthesized in yields ranging from 50-70 and their cytotoxicity against colon cancer cells (CaCo-2) and the parasite Leishmania infantum determined using the MTT assay and by luciferase activity present in parasite, respectively. Cytotoxicity within CaCo-2 cells was manifested with IC50 values between 0.3 and 22 m M after 48 h of compounds incubation. Against Leishmania infantum, IC50 values were encompassed within a narrower concentration range of 0.39-2.09 m M, for pro-mastigote form, and between 5.24 and 17.42 m M, for axenic amastigote and between 2.43 and 9.52 m M, for intracellular amastigote forms.
    Type: Application
    Filed: June 15, 2007
    Publication date: March 5, 2009
    Inventors: Anabela Cordeiro Da Silva, Joana Alexandra Pinto Da Costa Tavares, Paul Kong Thoo Lin