Abstract: The present invention relates to chemical compounds with anti-cancer and anti-parasite activity. The invention relates, above all, to novel bisnaphthalimidopropyl derivatives with specific cytotoxic activity towards human cancer cells and protozoan cells capable of causing parasitic diseases in humans. The invention further relates to chemical compounds to be administered especially to humans and in particular for therapeutic use.

Abstract: A polymer having a structure according to the following formula (I): wherein: A represents a hydrophilic group; B represents a hydrophobic aromatic group such as 5-dimethylamino-1-naphthalenesulfonyl (Dansyl), 9-fluorenylmethoxy carbonyl (Fmoc) and naphthalene (Naphth); D and E independently represent amine groups; F represents an amine group, the amine group being substituted with a B group and an A group, or the amine group being a quaternary ammonium moiety; wherein W, X, Y and Z each independently have values greater than or equal to (1), especially in the range of (1) to (10).

Abstract: Flavonoid-type compounds of the Formula (II); in which R1 is alkyl C2 to C20, R2, R3, R4 and R5 are any one or more of hydrogen, alkyl, alkenyl, alkynyl, phenyl or benzyl, especially 7-decyl-3-hydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopy-ran-4-one or 7-ethyl-3-hydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one provide fluorescent probes and antioxidants, and are useful in discriminating healthy and stressed cells.

Abstract: The bisnaphthalimidopropyl derivatives with anti-parasitic and anti-cancer activity. Bisnaphthalimidopropyl derivatives (A) BNIPPut, BNIPDapen, BNIPDhex, BNIPDahep, BNIPDaoct, BNIPDanon, BNTPDadec, BNIPDadod, BNPDpta, BNIPDeta were synthesized in yields ranging from 50-70 and their cytotoxicity against colon cancer cells (CaCo-2) and the parasite Leishmania infantum determined using the MTT assay and by luciferase activity present in parasite, respectively. Cytotoxicity within CaCo-2 cells was manifested with IC50 values between 0.3 and 22 m M after 48 h of compounds incubation. Against Leishmania infantum, IC50 values were encompassed within a narrower concentration range of 0.39-2.09 m M, for pro-mastigote form, and between 5.24 and 17.42 m M, for axenic amastigote and between 2.43 and 9.52 m M, for intracellular amastigote forms.

Abstract: C.sub.4 hydrocarbons are separated from a gaseous mixture containing the same and lower hydrocarbons and hydrogen, by cooling such a gaseous mixture (45) to a temperature between -60.degree. F. and +32.degree. F. until a portion of the C.sub.4 hydrocarbons is condensed. The mixture of gas and liquid C.sub.4 hydrocarbons thus produced is phase separated in a first phase separation (53), and the liquid from this first phase separation is withdrawn as C.sub.4 hydrocarbons product (69). Gas from the first phase separation (53) is further cooled (47) until substantially all of the remaining C.sub.4 hydrocarbons are condensed but not the hydrogen. The latter material is subjected to a second phase separation (75), and liquid from the second phase separation (77) is withdrawn as liquid C.sub.4 hydrocarbons product (69).

Abstract: C.sub.4 hydrocarbons are separated from a gaseous mixture containing the same and lower hydrocarbons and hydrogen, by cooling such a gaseous mixture (45) to a temperature between -60.degree. F. and +32.degree. F. until a portion of the C.sub.4 hydrocarbons is condensed. The mixture of gas and liquid C.sub.4 hydrocarbons thus produced is phase separated in a first phase separation (53), and the liquid from this first phase separation is withdrawn as C.sub.4 hydrocarbons product (69). Gas from the first phase separation (53) is further cooled(47) until substantially all of the remaining C.sub.4 hydrocarbons are condensed but not the hydrogen. The latter material is subjected to a second phase separation (75), and liquid from the second phase separation (77) is withdrawn as liquid C.sub.4 hydrocarbons product (69).