Patents by Inventor Paul Kosnik

Paul Kosnik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230332095
    Abstract: The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.
    Type: Application
    Filed: January 18, 2023
    Publication date: October 19, 2023
    Applicant: TISSUE GENESIS INTERNATIONAL LLC
    Inventors: Gregory D. ARIFF, Thomas CANNON, Jennifer L. CASE, Christian L. HALLER, Paul KOSNIK, Charles P. LUDDY, Craig A. MAUCH, Erik VOSSMAN, Stuart K. WILLIAMS
  • Patent number: 11584912
    Abstract: The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: February 21, 2023
    Assignee: TISSUE GENESIS, INC
    Inventors: Gregory D. Ariff, Thomas Cannon, Jennifer L. Case, Christian L. Haller, Paul Kosnik, Charles P. Luddy, Craig A. Mauch, Erik Vossman, Stuart K. Williams
  • Publication number: 20200024568
    Abstract: The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.
    Type: Application
    Filed: September 28, 2015
    Publication date: January 23, 2020
    Applicant: Tissue Genesis, Inc.
    Inventors: Gregory D. Ariff, Thomas Cannon, Jennifer L. Case, Christian L. Haller, Paul Kosnik, Charles P. Luddy, Craig A. Mauch, Erik Vossman, Stuart K. Williams
  • Patent number: 9683210
    Abstract: The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: June 20, 2017
    Assignee: Tissue Genesis, LLC
    Inventors: Gregory D. Ariff, Thomas Cannon, Jennifer L. Case, Christian L. Haller, Paul Kosnik, Charles P. Luddy, Craig A. Mauch, Erik Vossman, Stuart K. Williams
  • Publication number: 20160237396
    Abstract: The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.
    Type: Application
    Filed: September 28, 2015
    Publication date: August 18, 2016
    Applicant: Tissue Genesis, LLC
    Inventors: Gregory D. Ariff, Thomas Cannon, Jennifer L. Case, Christian L. Haller, Paul Kosnik, Charles P. Luddy, Craig A. Mauch, Erik Vossman, Stuart K. Williams
  • Patent number: 9144583
    Abstract: The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.
    Type: Grant
    Filed: April 23, 2007
    Date of Patent: September 29, 2015
    Assignee: Tissue Genesis, Inc.
    Inventors: Gregory D. Ariff, Thomas Cannon, Jennifer L. Case, Christian L. Haller, Paul Kosnik, Charles P. Luddy, Craig A. Mauch, Erik Vossman, Stuart K. Williams
  • Patent number: 7906323
    Abstract: The present invention provides a feedback controlled bioculture platform for use as a precision cell biology research tool and for clinical cell growth and maintenance applications. The system provides individual closed-loop flowpath cartridges, with integrated, aseptic sampling and routing to collection vials or analysis systems. The system can operate in a standard laboratory or other incubator for provision of requisite gas and thermal environment. System cartridges are modular and can be operated independently or under a unified system controlling architecture, and provide for scale-up production of cell and cell products for research and clinical applications. Multiple replicates of the flowpath cartridges allow for individual, yet replicate cell culture growth and multiples of the experiment models that can be varied according to the experiment design, or modulated to desired cell development of cell culture end-points.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: March 15, 2011
    Assignee: Tissue Genesis, Inc.
    Inventors: Thomas F. Cannon, Laura K. Cohn, Peter D. Quinn, Paul Kosnik
  • Publication number: 20080058763
    Abstract: A cell delivery system and method for delivering cells locally to a tissue, body cavity, or joint is described. The cell delivery system comprises a catheter configured to deliver stem cells in a pressure controlled manner. The catheter may comprise an inner bladder and an outer perforated bladder. The inner bladder may be expanded through the use of a pressure conduit in order to deploy a stent. Cells, such as endothelial cells derived from adipose tissue, may be introduced between the inner and outer bladder. The inner bladder may be further expanded in order to exert pressure on the outer perforated bladder to advance the stems cells though the apertures of the outer bladder. The inner bladder may remain pressurized to hold the outer bladder against the vessel wall, thereby directing the stem cells to specific target sites. The system may be used to deliver stem cells with or without other therapeutic agents. The system may be used with or without a stent.
    Type: Application
    Filed: August 29, 2007
    Publication date: March 6, 2008
    Applicant: Tissue Genesis, Inc.
    Inventors: Eugene Boland, Stuart Williams, Paul Kosnik
  • Publication number: 20080014181
    Abstract: The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.
    Type: Application
    Filed: April 23, 2007
    Publication date: January 17, 2008
    Inventors: Gregory Ariff, Thomas Cannon, Jennifer Case, Christian Haller, Paul Kosnik, Charles Luddy, Craig Mauch, Erik Vossman, Stuart Williams
  • Publication number: 20060258004
    Abstract: Tissue engineering methods and biochamber apparatus are provided for making tissue grafts for implantation into a patient. The methods include applying a sustained low magnitude pressure gradient transmurally across a permeable scaffold material using a media containing cells, preferably microvascular epithelial cells, to be deposited on the scaffold for the production of tissue grafts, preferably vascular grafts, to promote accelerated adhesion and maturation of cells on the scaffold material. Biochambers for preparing tubular tissue grafts are provided which contain connectors for holding a graft substrate, proximal and distal tubing for connection to an optional perfusion system, and structure for switching between transmural flow of a cell suspension across the graft substrate and translumenal flow through the lumen of the graft.
    Type: Application
    Filed: December 22, 2005
    Publication date: November 16, 2006
    Inventors: Paul Kosnik, Christopher England, Robert Dennis, Stuart Williams
  • Publication number: 20050186671
    Abstract: The present invention provides a feedback controlled bioculture platform for use as a precision cell biology research tool and for clinical cell growth and maintenance applications. The system provides individual closed-loop flowpath cartridges, with integrated, aseptic sampling and routing to collection vials or analysis systems. The system can operate in a standard laboratory or other incubator for provision of requisite gas and thermal environment. System cartridges are modular and can be operated independently or under a unified system controlling architecture, and provide for scale-up production of cell and cell products for research and clinical applications. Multiple replicates of the flowpath cartridges allow for individual, yet replicate cell culture growth and multiples of the experiment models that can be varied according to the experiment design, or modulated to desired cell development of cell culture end-points.
    Type: Application
    Filed: February 24, 2005
    Publication date: August 25, 2005
    Inventors: Thomas Cannon, Laura Cohn, Peter Quinn, Paul Kosnik
  • Patent number: 6777234
    Abstract: A mammalian muscle construct and a method for producing the construct are provided. The mammalian muscle construct includes a substrate and a plurality of separate anchors secured to the substrate. Myogenic precursor cells are provided on the substrate with at least some of the cells in contact with the anchors. The myogenic precursor cells are cultured in vitro under conditions to allow the cells to become confluent between the anchors. The anchors are receptive to the cells and allow the cells to attach thereto, such that placement of the anchors controls the size and shape of the muscle construct formed. Specifically, the anchors include separate fragments of biocompatible material secured to the substrate, wherein cell adhesion molecules are associated with each fragment to facilitate attachment of the precursor cells to the fragment.
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: August 17, 2004
    Assignee: The Regents of the University of Michigan
    Inventors: Robert G. Dennis, Paul Kosnik, William M. Kuzon, Jr., John A. Faulkner
  • Publication number: 20020146817
    Abstract: The present invention provides a feedback controlled bioculture platform for use as a precision cell biology research tool and for clinical cell growth and maintenance applications. The system provides individual closed-loop flowpath cartridges, with integrated, aseptic sampling and routing to collection vials or analysis systems. The system can operate in a standard laboratory or other incubator for provision of requisite gas and thermal environment. System cartridges are modular and can be operated independently or under a unified system controlling architecture, and provide for scale-up production of cell and cell products for research and clinical applications. Multiple replicates of the flowpath cartridges allow for individual, yet replicate cell culture growth and multiples of the experiment models that can be varied according to the experiment design, or modulated to desired cell development of cell culture end-points.
    Type: Application
    Filed: April 1, 2002
    Publication date: October 10, 2002
    Inventors: Thomas F. Cannon, Laura K. Cohn, Peter D. Quinn, Paul Kosnik
  • Patent number: 6303286
    Abstract: A system and method are provided for adaptively controlling a muscle tissue specimen in order to emulate its in vivo environment. The system includes at least one stimulator for stimulating the muscle tissue specimen based on an initial control signal, wherein the stimulation preferably includes electrical and/or mechanical stimulation. A response signal is generated based on a response of the muscle tissue specimen to the step of stimulating. The response signal preferably represents force production of the tissue specimen. A controller is provided for modifying the initial control signal based on the response signal to obtain a final control signal, wherein the final control signal is used to elicit a desired response from the muscle tissue specimen. Advantageously, the system and method of the present invention can be used to adaptively control the stimulation of a muscle tissue specimen in a tissue culture environment.
    Type: Grant
    Filed: July 6, 2000
    Date of Patent: October 16, 2001
    Assignee: The Regents of the University of Michigan
    Inventors: Robert G. Dennis, Paul Kosnik
  • Patent number: 6207451
    Abstract: A mammalian muscle construct and a method for producing the construct are provided. The mammalian muscle construct includes a substrate and a plurality of separate anchors secured to the substrate. Myogenic precursor cells are provided on the substrate with at least some of the cells in contact with the anchors. The myogenic precursor cells are cultured in vitro under conditions to allow the cells to become confluent between the anchors. The anchors are receptive to the cells and allow the cells to attach thereto, such that placement of the anchors controls the size and shape of the muscle construct formed. Specifically, the anchors include separate fragments of biocompatible material secured to the substrate, wherein cell adhesion molecules are associated with each fragment to facilitate attachment of the precursor cells to the fragment.
    Type: Grant
    Filed: September 15, 1998
    Date of Patent: March 27, 2001
    Assignee: The Regents of the University of Michigan
    Inventors: Robert G. Dennis, Paul Kosnik, William M. Kuzon, Jr., John A. Faulkner
  • Patent number: 6114164
    Abstract: A system and method are provided for adaptively controlling a muscle tissue specimen in order to emulate its in vivo environment. The system includes at least one stimulator for stimulating the muscle tissue specimen based on an initial control signal, wherein the stimulation preferably includes electrical and/or mechanical stimulation. A response signal is generated based on a response of the muscle tissue specimen to the step of stimulating. The response signal preferably represents force production of the tissue specimen. A controller is provided for modifying the initial control signal based on the response signal to obtain a final control signal, wherein the final control signal is used to elicit a desired response from the muscle tissue specimen. Advantageously, the system and method of the present invention can be used to adaptively control the stimulation of a muscle tissue specimen in a tissue culture environment.
    Type: Grant
    Filed: December 7, 1998
    Date of Patent: September 5, 2000
    Assignee: The Regents of the University of Michigan
    Inventors: Robert G. Dennis, Paul Kosnik