Patents by Inventor Paul Kotzbauer

Paul Kotzbauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alpha-synuclein ligands
    Patent number: 10300155
    Abstract: The present invention generally relates to various compounds that are useful as ?-synuclein ligands. The invention further relates to methods of using these compounds and their radiolabeled analogs for the detection of synucleinopathies, including Parkinson's disease (PD).
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: May 28, 2019
    Assignee: Washington University
    Inventors: Zhude Tu, Junfeng Li, Xuyi Yue, Paul Kotzbauer
  • ALPHA-SYNUCLEIN LIGANDS
    Publication number: 20170189566
    Abstract: The present invention generally relates to various compounds that are useful as ?-synuclein ligands. The invention further relates to methods of using these compounds and their radiolabeled analogs for the detection of synucleinopathies, including Parkinson's disease (PD).
    Type: Application
    Filed: December 29, 2016
    Publication date: July 6, 2017
    Applicant: Washington University
    Inventors: Zhude Tu, Junfeng Li, Xuyi Yue, Paul Kotzbauer
  • TRICYCLIC HETEROAROMATIC COMPOUNDS AS ALPHA-SYNUCLEIN LIGANDS
    Publication number: 20130315825
    Abstract: Derivatives of phenothiazine, phenoxazine, and phenazine compounds and their use as ?-synuclein ligands are described. Also described are methods of using these compounds and their radiolabeled analogs for the detection, monitoring, and treatment of synucleinopathies, including Parkinson's disease.
    Type: Application
    Filed: May 3, 2013
    Publication date: November 28, 2013
    Applicant: Washington University
    Inventors: Zhude Tu, Robert Mach, Lihai Yu, Paul Kotzbauer
  • Persephin and related growth factors
    Publication number: 20050234226
    Abstract: A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The human, mouse and rat amino acid sequences have been identified. Human, mouse and rat persephin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using persephin, methods for detecting persephin gene alterations and methods for detecting and monitoring patient levels of persephin are provided. Methods for identifying additional members of the persephin-neurturin-GDNF family of growth factors are also provided.
    Type: Application
    Filed: January 18, 2005
    Publication date: October 20, 2005
    Inventors: Eugene Johnson, Jeffrey Milbrandt, Paul Kotzbauer, Patricia Lampe, Robert Klein, Fred DeSauvage