Patents by Inventor Paul L. Bergstein

Paul L. Bergstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ester-substituted diaminedithiols and radiolabeled complexes thereof
    Patent number: 5431900
    Abstract: Radiopharmaceuticals consisting essentially of a lipophilic, charge neutral radionuclide complex of a diaminedithiol ligand having 1-4 ester groups of the formula --A--COOR where A is a straight or branched chain alkylene of 0-10 carbon atoms and R is an alkyl group of 1-10 carbon atoms are useful in radioimaging brain perfusion in primates. Ester-substituted diaminedithiols in sterile, pharmaceutically acceptable form, and kits of the diaminedithiols and sterile, non-pyrogenic reducing agents for reducing preselected radionuclides are also provided. Technetium-99m is a preferred radionuclide.
    Type: Grant
    Filed: October 20, 1993
    Date of Patent: July 11, 1995
    Assignee: The Du Pont Merck Pharmaceutical Company
    Inventors: Paul L. Bergstein, Edward H. Cheesman, Alan D. Watson
  • Ester-substituted diaminedithiols and radiolabeled complexes thereof
    Patent number: 5279811
    Abstract: Radiopharmaceuticals consisting essentially of a lipophilic, charge neutral radionuclide complex of a diaminedithiol ligand having 1-4 ester groups of the formula --A--COOR where A is a straight or branched chain alkylene of 0-10 carbon atoms and R is an alkyl group of 1-10 carbon atoms are useful in radioimaging brain perfusion in primates. Ester-substituted diaminedithiols in sterile, pharmaceutically acceptable form, and kits of the diaminedithiols and sterile, non-pyrogenic reducing agents for reducing preselected radionuclides are also provided. Technetium-99m is a preferred radionuclide.
    Type: Grant
    Filed: January 26, 1988
    Date of Patent: January 18, 1994
    Assignee: The Du Pont Merck Pharmaceutical Company
    Inventors: Paul L. Bergstein, Edward H. Cheesman, Alan D. Watson
  • Ether isonitriles and radiolabeled complexes thereof
    Patent number: 4988827
    Abstract: Ether-substituted isonitriles, Tc99m complexes thereof, and processes for myocardial tissue radioimaging using the Tc99m complexes.
    Type: Grant
    Filed: June 1, 1987
    Date of Patent: January 29, 1991
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Paul L. Bergstein, Vinayakam Subramanyam