Abstract: It has now been found that compounds of the present invention as described in Benzodiazepine derivatives of Formula (I) containing a carboxylic ester moiety and thereby capable of being inactivated by nonspecific tissue esterases in an organ-independent elimination mechanism and thereby providing a more predictable and reproducible pharmacodynamic profile. The compounds of the present invention are suitable for therapeutic purposes, including sedative-hypnotic, anxiolytic, muscle relaxant and anticonvulsant purposes and are useful to be administered intravenously in the following clinical settings: preoperative sedation, anxiolysis, and amnestic use for perioperative events; conscious sedation during short diagnostic, operative or endoscopic procedures; as a component for the induction and maintenance of general anesthesia, prior and/or concomitant to the administration of other anesthetic agents; ICU sedation.

Abstract: The present invention provides a compound of formula (I): wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.

Abstract: The present invention provides a compound of formula (I): wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.

Abstract: The present invention provides a compound of formula (I): wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.

Abstract: The present invention provides a compound of formula (I): wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.

Abstract: Electrically enhanced filter, includes a filter element, a pair of electrodes sandwiching the filter element, a DC, AC, pulse, or RF power supply coupled to the electrode to create an electrostatic field across the filter element and to produce attracting forces between micro-organisms contained in the air and the filter element, and a power supply creating a sterilizing electrical field, which may be either an RF, DC, pulse, or AC power supply coupled to the electrodes and creating discharging or non-discharging voltages on the filter element to destruct the micro-organisms at and in the vicinity of the filter element.

Abstract: A method of filtering air includes the steps of providing a filter element, providing a pair of electrodes sandwiching the filter element, applying a DC electrostatic field to the electrodes to produce attracting forces between particulates and micro-organisms contained in the air and the filter element, and intermittently applying a sterilizing electrical field concurrently with the electrostatic field. An RF, DC pulse, or AC power supply can be used to generate the sterilizing electrical field.

Abstract: A corona discharge reactor (10) and method for chemically activating various constituents of a gas stream by use of corona discharge is provided. The corona discharge reactor (10) includes within a conduit a discharge plate (30a,b) having a plurality of through openings (33) and a plurality of projecting corona discharge electrodes (31,31',35,35'), and an electrode plate (40a,b,c) having a plurality of through openings (43) displaced from and opposing the tips (32) of the corona discharge electrodes (31,31',35,35'). A pulsed energization scheme is employed to intermittently generate a uniformly distributed corona discharge cloud (1000) between the plurality of corona discharge electrode tips (32) and the electrode plate (40a,b,c) during passage of the gas stream through the conduit.

Abstract: An electrostatic precipitation system (100) utilizes laminar flow of a particulate-laden gas in order to enhance the removal of sub-micron sized particulates. The system incorporates a vertically oriented housing (105) through which the gas flows downwardly therethrough to a lower outlet port (110). The gas, which may be a flue gas enters the laminar flow precipitator (102) through an inlet port (108) for passage through a charging section (104). The charging section (104) imparts a charge to the particulates carried by the flue gas. The flue gas and charged particles then flow to a collecting section (106) which is downstream and below the charging section (104). The collecting section (106) is formed by a plurality of substantially parallel tubular members, each tubular member defining a collecting passage therein.

Abstract: A system incorporating an agglomerator is provided for removing fine particulates from a gas stream. The agglomerator (100) is coupled to a flue (12) for agglomerating fines (30) entrained in a gas stream, the agglomerates (40) reentrained into the gas stream are carried by ductwork (14) to an existing particulate removal system (20). Agglomerator (100) includes at least two screen electrodes (102, 104) for charging the particulates (30) and temporarily collecting the charged particles on the collection electrode screen (104). The charging electrode (102) is provided with a plurality of spaced pointed electrode elements (108), the spacing therebetween being proportional to a spacing between the two screen electrodes (102, 104). The screen electrodes (102, 104) have a grid spacing sufficiently large to insure reentrainment of the agglomerates (40) back into the bulk gas stream for separation by the existing particulate removal system (20).

Abstract: An electrostatic precipitation system (100) utilizes laminar flow of a particulate-laden gas in order to enhance the removal of sub-micron sized particulates. The system incorporates a vertically oriented housing (105) through which the gas flows downwardly therethrough to a lower outlet port (110). The gas, which may be a flue gas enters the laminar flow precipitator (102) through an inlet port (108) for passage through a charging section (104). The charging section (104) imparts a charge to the particulates carried by the flue gas. The flue gas and charged particles then flow to a collecting section (106) which is downstream and below the charging section (104). The collecting section (106) is formed by a plurality of substantially parallel tubular members, each tubular member defining a collecting passage therein.

Abstract: Novel piperidinyl intermediates as set forth below wherein R, R.sup.1 and Ar are as set forth in the specification and W is either hydrogen or benzyloxycarbonyl. The intermediates are useful in the preparation of N-phenyl-N-(4-piperidinyl) amides having potent analgesic activity.

Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I): ##STR1## wherein X, Ar, R and R.sup.1 are defined, including isomeric forms thereof and acid addition salts thereof. The compounds exhibit analgesic activity. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).

Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I): ##STR1## wherein X, Ar, R and R.sup.1 are defined, including isomeric forms thereof and acid addition salts thereof. The compounds exhibit analgesic activity. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).

Abstract: A method of preparing certain substituted alkali metal 4-carboxy-piperidine salts (I) by alkaline hydrolysis of certain novel substituted 1,3,8-triazaspiro[4.5]decane-2, 4-diones (IV) which in turn are obtained from certain novel substituted chlorosulphonylamido piperidines (III).

Abstract: A method of preparing certain substituted alkali metal 4-carboxy-piperidine salts (I) by alkaline hydrolysis of certain novel substituted 1,3,8-triazaspiro[4.5]decane-2, 4-diones (IV) which in turn are obtained from certain novel substituted chlorosulphonylamido piperidines (III).

Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I): ##STR1## wherein X is a member selected from the group consisting of alkoxy-carbonyl-lower alkyl, lower alkyl-carbonyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C.sub.1-2)alkoxy-(C.sub.1-2)-alkoxy-carbonyl-lower alkyl, and Ar, R, R.sup.1 and R.sup.2 are defined hereinafter, including isomeric forms thereof and acid addition salts thereof. The compounds exhibit analgesic activity having relatively short durations of analgesic action. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).

Abstract: A method for reduced temperature operation of flue gas collectors is disclosed wherein the benefits of low temperature operation are made possible by avoidance of the acid dewpoint limit. The process increases the specific collecting area of the collector, results in lower pressure drop through the collector and, where the collector is an electrostatic precipitator, allows improved collection efficiency through higher electric field strength and reduced particulate resistivity.

Abstract: A process uses limestone injection into a combustion boiler burning pulverized coal or liquid hydrogen fuel. Effluent gas from the boiler is humidified and cooled to below 200.degree. F. During the humidifying and cooling step, sulfur dioxide removal occurs in addition to that which takes place in the combustion zone of the boiler. The effluent gas and unreacted alkali is then fed into an electron beam irradiation chamber which produces energetic conditions for rapid reaction of sulfur dioxide and nitrogen oxides in the presence of water vapor. The remaining unreacted alkali reacts rapidly and in-situ with the sulfuric acid and nitric acid formed in the electron beam chamber.

Abstract: Converting both organic and inorganic sulfur compounds in coal to removable forms utilizing electron beam irradiation. The removable forms of sulfur include elemental suflur, gaseous compounds, and water-soluble compounds. Coal is pulverized and slurried and introduced into the electron beam reaction chamber where the conversion reactions take place. As a further benefit, coal dechlorination inherently results.