Patents by Inventor Paul L. Modrich

Paul L. Modrich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for identifying inhibitors of MutS? or MutS? interaction with MutL?
    Patent number: 8623600
    Abstract: Disclosed are methods and kits for screening potential inhibitors of MutS? by screening agents for the ability to selectively inhibit interaction between MutS? and MutL?. Also disclosed are kits for performing the methods of the invention.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: January 7, 2014
    Assignees: Duke University, The United States of America, as Represented by the Secretary of Energy
    Inventors: Paul L. Modrich, Ravi R. Iyer, Anna Pluciennik, Miaw-Sheue Tsai
  • METHODS AND COMPOSITIONS FOR IDENTIFYING INHIBITORS OF MUTS-alpha OR MUTS-beta INTERACTION WITH MUTL-alpha
    Publication number: 20110195849
    Abstract: Disclosed are methods and kits for screening potential inhibitors of MutS? by screening agents for the ability to selectively inhibit interaction between MutS? and MutL?. Also disclosed are kits for performing the methods of the invention.
    Type: Application
    Filed: February 11, 2011
    Publication date: August 11, 2011
    Applicant: DUKE UNIVERSITY
    Inventors: Paul L. Modrich, Ravi R. Iyer, Anna Pluciennik, Miaw-Sheue Tsai
  • Method of analysis and manipulation of DNA utilizing mismatch repair systems
    Patent number: 6008031
    Abstract: A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.
    Type: Grant
    Filed: June 17, 1997
    Date of Patent: December 28, 1999
    Assignee: Duke University
    Inventors: Paul L. Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue, Deani Lee Cooper, Leroy Worth, Jr.
  • Methods for use of mismatch repair systems for the detection and removal of mutant sequences that arise during enzymatic amplification
    Patent number: 5922539
    Abstract: Method for removing DNA molecules containing one or more polymerase-generated mutations in a population of enzymatically amplified DNA duplexes comprising the steps of denaturing and reannealing the population of DNA duplexes, contacting the reannealled DNA duplexes with a mismatch repair system such that each strand is cleaved in DNA duplexes containing a base pair mismatch, and separating the cleaved DNA duplexes from uncleaved DNA duplexes.
    Type: Grant
    Filed: December 13, 1996
    Date of Patent: July 13, 1999
    Assignee: Duke University
    Inventors: Paul L. Modrich, Jane E. Smith
  • Solutions containing mismatch repair system proteins mutL and mutS
    Patent number: 5861482
    Abstract: A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: January 19, 1999
    Assignee: Duke University
    Inventors: Paul L. Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue, Deani Lee Cooper, Leroy Worth, Jr.
  • Methods of analysis and manipulation of DNA utilizing mismatch repair systems
    Patent number: 5858754
    Abstract: A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.
    Type: Grant
    Filed: February 13, 1996
    Date of Patent: January 12, 1999
    Assignee: Duke University
    Inventors: Paul L. Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue, Deani Lee Cooper, Leroy Worth, Jr.
  • Methods of analysis and manipulating of DNA utilizing mismatch repair systems
    Patent number: 5702894
    Abstract: A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: December 30, 1997
    Assignee: Duke University
    Inventors: Paul L. Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue, Deani Lee Cooper, Leroy Worth, Jr.
  • Methods of analysis and manipulation of DNA utilizing mismatch repair systems
    Patent number: 5679522
    Abstract: A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: October 21, 1997
    Assignee: Duke University
    Inventors: Paul L. Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue, Deani Lee Cooper, Leroy Worth, Jr.
  • Methods and kits for fractionating a population of DNA molecules based on the presence or absence of a base-pair mismatch utilizing mismatch repair systems
    Patent number: 5556750
    Abstract: A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: September 17, 1996
    Assignee: Duke University
    Inventors: Paul L. Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue, Deani L. Cooper, Leroy Worth, Jr.