Abstract: Brush copolymers containing (a) monomeric units derived from an ethylenically unsaturated-containing monomer containing one or more boronic acid moieties; and (b) monomeric units derived from an ethylenically unsaturated-containing macromonomer having hydrophilic units and boronic acid units are disclosed.

Abstract: Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed. A packaging system includes an ophthalmic device stored in an aqueous packaging solution comprising a brush copolymer comprising (a) monomeric units derived from an ethylenically unsaturated monomer containing one or more boronic acid moieties; and (b) monomeric units derived from an ethylenically unsaturated-containing hydrophilic macromonomer.

Abstract: Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed.

Abstract: Brush copolymers containing (a) monomeric units derived from an ethylenically unsaturated monomer containing one or more boronic acid moieties and; and (b) monomeric units derived from an ethylenically unsaturated-containing hydrophilic macromonomer are disclosed.

Abstract: Brush copolymers containing (a) monomeric units derived from an ethylenically unsaturated-containing monomer containing one or more boronic acid moieties; and (b) monomeric units derived from an ethylenically unsaturated-containing macromonomer having hydrophilic units and boronic acid units are disclosed.

Abstract: Disclosed are biomedical devices having a hydrophilic coating on a portion of a surface thereof, the biomedical device comprising: (a) a biomedical device obtained from a polymerization product of a monomeric mixture comprising (i) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (ii) a biomedical device-forming comonomer; and (b) a hydrophilic reactive polymer having complementary reactive functionalities along the polymer chain, wherein the complementary reactive functionalities along the polymer chain of the hydrophilic reactive polymer of (b) bind with the boronic acid moieties of the biomedical device of (a), thereby producing a biocompatible coating which can be removed and re-applied to restore the surface properties of the biomedical device to substantially as-new condition. Methods for treating the biomedical device are also disclosed.

Abstract: Described herein are implantable medical devices comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue. The triggerable bioadhesive property of the polymer can be triggered or activated by exposure to a stimulus. Also, the present invention pertains to methods of making an implantable medical device comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue.

Abstract: A biomedical device, such as a contact lens, has a surface linked to a polymer comprising boronic acid moieties. The boronic acid monomeric units may be derived from an ethylenically unsaturated monomer containing a boronic acid moiety, such as a vinylphenyl boronic acid or a (meth)acrylamido phenyl boronic acid. The boronic acid moieties may be complexed with mucin, especially epithelial mucin.

Abstract: Disclosed are biomedical devices having a hydrophilic coating on a portion of a surface thereof, the biomedical device comprising: (a) a biomedical device obtained from a polymerization product of a monomeric mixture comprising (i) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (ii) a biomedical device-forming comonomer; and (b) a hydrophilic reactive polymer having complementary reactive functionalities along the polymer chain, wherein the complementary reactive functionalities along the polymer chain of the hydrophilic reactive polymer of (b) bind with the boronic acid moieties of the biomedical device of (a), thereby producing a biocompatible coating which can be removed and re-applied to restore the surface properties of the biomedical device to substantially as-new condition. Methods for treating the biomedical device are also disclosed.

Abstract: Disclosed are surface modified biomedical devices having a coating on a surface thereof, the coating comprising an inner layer comprising a polymer comprising monomeric units derived from an ethylenically unsaturated monomer containing a boronic acid moiety, and an outer layer comprising a hydrophilic hydrolyzed reactive polymer comprising monomeric units derived from an ethylenically unsaturated containing monomer having hydrolyzable reactive functionalities.

Abstract: Brush copolymers containing (a) monomeric units derived from an ethylenically unsaturated-containing monomer containing one or more boronic acid moieties; and (b) monomeric units derived from an ethylenically unsaturated-containing macromonomer having hydrophilic units and boronic acid units are disclosed.

Abstract: Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed. A packaging system includes an ophthalmic device stored in an aqueous packaging solution comprising a brush copolymer comprising (a) monomeric units derived from an ethylenically unsaturated monomer containing one or more boronic acid moieties; and (b) monomeric units derived from an ethylenically unsaturated-containing hydrophilic macromonomer.

Abstract: Biomedical devices are provided herein which are formed from a polymerization product of a monomeric mixture comprising (a) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (b) a biomedical device-forming comonomer.

Abstract: Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed.

Abstract: Brush copolymers containing (a) monomeric units derived from an ethylenically unsaturated monomer containing one or more boronic acid moieties and; and (b) monomeric units derived from an ethylenically unsaturated-containing hydrophilic macromonomer are disclosed.

Abstract: Described herein are implantable medical devices comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue. The triggerable bioadhesive property of the polymer can be triggered or activated by exposure to a stimulus. Also, the present invention pertains to methods of making an implantable medical device comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue.

Abstract: A contact lens is coated with a layer of a polymer having affinity for mucin, such as a polymer with boronic acid moieties. This polymer is coated with a diol. While the contact lens is worn, the diol is replaced with mucin.

Abstract: Surface modified medical devices such as intraocular lens implants formed from one or more functional group-containing materials using reactive, hydrophilic polymers with catalyst functionality for the purpose of reducing or eliminating lens epithelial cell growth thereon, reducing or eliminating silicone oil absorption upon subsequent surgical exposure and/or reducing implantation inserter friction is provided herein. Additionally, a method of making and using surface modified intraocular lens implants is provided.

Abstract: Surface modified medical devices such as intraocular lens implants formed from one or more functional group-containing materials using reactive, hydrophilic polymers for the purpose of reducing or eliminating lens epithelial cell growth thereon, reducing or eliminating silicone oil absorption upon subsequent surgical exposure and/or reducing or eliminating implantation inserter friction is provided herein. Additionally, a method of making and using surface modified intraocular lens implants is provided.

Abstract: The present invention provides an optically clear, hydrophilic coating upon the surface of a silicone medical device by sequentially subjecting the surface of the lens to plasma polymerization in a hydrocarbon-containing atmosphere and then covalently attaching a preformed hydrophilic polymer to the surface of the carbon coating. The invention is especially useful for forming a biocompatible coating on a silicone contact lens.