Abstract: The invention relates to stable formulations of cyclic dinucleotide STING agonist compounds or pharmaceutically acceptable salts thereof. The invention further provides methods for treating various cancers with stable formulations of the invention. In some embodiments of the methods of the invention, the formulations are administered to a subject by intratumoral or subcutaneous administration.

Abstract: A novel electrochemical cell including a solid electrolyte heated to an elevated temperature for operation and an integral cell electrode/heater for heating the electrolyte. Solid electrolyte embodiments are described. The integral electrode/heater is applied to a surface of the solid electrolyte and is resistively heated by an alternating electric current. A portion of the solid electrolyte may also be resistively heated. The described or comparable cells may be incorporated into an oxygen detector or similar apparatus where the apparatus is operated by alternately heating the cell and measuring the emf developed by the cell across its electrode.The invention is also, in part, a unique, solid electrolyte-integral cell electrode/heater configuration which provides a zone of uniform maximum heating at a predetermined location within the electrolyte and which, when used with a suitable resistive heating electric current, confines the current to the integral electrode/heater prolonging cell life.

Abstract: The invention includes a simple and inexpensive thermal controller and simple and inexpensive radio frequency alternating current generator which are provided in an improved temperature control system for a resistively heated electrochemical cell. The temperature controller is formed by a single amplifier with feedback circuit which provides the function of a combined deviation amplifier and two mode (percent proportional band and integral functions) controller. The alternating current generator uses a single direct current voltage source to generate a radio frequency alternating electric current. The two elements are combined in a temperature control circuit for a resistively heated electrochemical cell. The control circuit provides an alternating current with varying power by cyclicly shutting the current off for irregular portions of a predetermined cycle period.