Abstract: A device, system and method are provided for controlling the rate of infusion of fluids during infusion therapy using non-electric infusion devices. Rotation of a flow regulator dial causes an orifice connected to the inlet to modify its position relative to a particular one or more orifices or groove portions, the characteristics of which provide a certain flow rate characteristic. The flow regulator allows for the Infusion pump to Infuse at a rate that may be varied during use by the user. Additionally, the flow regulator is made from a material selected to operate under a wide range of pressures, from 5-40 PSI, making the flow regulator compatible with pressurized devices, such as, a non-electric pump.

Abstract: An exemplary system includes a computing device configured to host a hypervisor. The hypervisor is configured to create a first container configured to host a first application and is allocated a first location of the plurality of locations of the memory and a second container configured to host a second application and is allocated a second location of the plurality of locations of the memory. During boot of the first container, the first container is configured to generate a cryptographic key that is based on a measurement or characteristic of process code of the first container, a configuration parameter of the first container, or any combination thereof. During boot of the second container, the second container is configured to generate a cryptographic key that is based on a measurement or characteristic of process code of the second container, a configuration parameter of the second container, or any combination thereof.

Abstract: A mechanical infusion system includes a housing having top and bottom portions. A pair of sliding slots extend transversely along the bottom portion. A hinge causes the top portion to connect with the bottom portion to form a closed position and separate from the bottom portion to form an open position. The housing forms engagement and syringe receiving cavities to respectively receive a flange and barrel of a syringe. A movable pusher is biased towards the engagement cavity so as to apply force to a plunger of the syringe. The infusion system also includes linkages configured to move transversely in a first direction upon opening of the top portion to cause the pusher to move away from the engagement cavity and move transversely in a second, opposite direction upon closing of the top portion to allow the pusher to retract towards the engagement cavity within the sliding slots.

Abstract: A device, system and method are provided for controlling the rate of infusion of fluids during infusion therapy using non-electric infusion devices. Rotation of a flow regulator dial causes an orifice connected to the inlet to modify its position relative to a particular one or more orifices or groove portions, the characteristics of which provide a certain flow rate characteristic. The flow regulator allows for the infusion pump to infuse at a rate that may be varied during use by the user. Additionally, the flow regulator is made from a material selected to operate under a wide range of pressures, from 5-40 PSI, making the flow regulator compatible with pressurized devices, such as, a non-electric pump.

Abstract: A device, system and method are provided for controlling the rate of infusion of fluids during infusion therapy using non-electric infusion devices. Rotation of a flow regulator dial causes an orifice connected to the inlet to modify its position relative to a particular one or more orifices or groove portions, the characteristics of which provide a certain flow rate characteristic. The flow regulator allows for the infusion pump to infuse at a rate that may be varied during use by the user. Additionally, the flow regulator is made from a material selected to operate under a wide range of pressures, from 5-40 PSI, making the flow regulator compatible with pressurized devices, such as, a non-electric pump.

Abstract: A device, system and method are provided for controlling the rate of infusion of fluids during infusion therapy using non-electric infusion devices. Rotation of a flow regulator dial causes an orifice connected to the inlet to modify its position relative to a particular one or more orifices or groove portions, the characteristics of which provide a certain flow rate characteristic. The flow regulator allows for the infusion pump to infuse at a rate that may be varied during use by the user. Additionally, the flow regulator is made from a material selected to operate under a wide range of pressures, from 5-40 PSI, making the flow regulator compatible with pressurized devices, such as, a non-electric pump.

Abstract: A transparent dressing includes a portion without adhesive to allow placement over a catheter to reduce any effect of placing and positioning of a catheter at the time of removal of the dressing. The transparent dressing may include at least one tab for handling and removing the dressing, the at least one tab being positioned on at least one outer edge of the dressing.

Abstract: The present invention provides methods of detecting responsiveness of cancers to immunotherapies and determining which treatment to use with a particular cancer. The methods include obtaining a sample from the subject and detecting the expression level of keratin 17 (K17) in the sample. Low levels of K17 expression indicates that the cancer is responsive to the immunotherapy and high levels of K17 expression indicate that the cancer is not responsive to immunotherapy and that other methods of treating the cancer should be used.

Abstract: A device for protecting a user from a sharp tip of a medical needle includes a central body portion, a medical needle having a sharp tip, a pair of wings in attachment to the central body portion, and a hook-and-loop fastening system disposed on at least one of the wings, and configured to selectively attach the wings together with the medical needle positioned between the wings so as to protect a user from the sharp tip of the medical needle. A method of using the device includes withdrawing a sharp tip of a medical needle from a patient, closing a pair of wings with the medical needle positioned between the wings, and fastening the wings together with the medical needle positioned between the wings so as to protect a user from the sharp tip of the medical needle.

Abstract: The invention is a high strength austenitic steel composition having increased strength and toughness characteristics, applicable for use in a seawater environment. The high strength austenitic steel may include nanometer-scale carbides, carbonitrides of vanadium, and carbides and carbonitrides having molybdenum, titanium, and niobium. The austenitic steel includes, 0.15-0.5 wt. % of carbon, 0-0.8 wt. % of silicon 6-14 wt. % of manganese, 9-13.5 wt. % of nickel, 0-3 wt. % of copper; 0.8-2.2 wt. % of vanadium, 0-4 wt. % of molybdenum, 0-4 wt. % of chromium; 0-0.9 wt. % of aluminum, 0-0.1 wt. % of calcium, 0-0.3 wt. % of titanium, 0-0.6 wt. % of niobium, 0-0.2 wt. % of tungsten, 0-0.2 wt. % of nitrogen, 0-0.1 wt. % of cerium, 0-0.1 wt. % of lanthanum, 0-0.05 wt. % of sulfur, and 0-0.05 wt. % of phosphorus.

Abstract: A device for protecting a user from a sharp tip of a medical needle includes a central body portion, a medical needle having a sharp tip, a pair of wings in attachment to the central body portion, and a hook-and-loop fastening system disposed on at least one of the wings, and configured to selectively attach the wings together with the medical needle positioned between the wings so as to protect a user from the sharp tip of the medical needle. A method of using the device includes withdrawing a sharp tip of a medical needle from a patient, closing a pair of wings with the medical needle positioned between the wings, and fastening the wings together with the medical needle positioned between the wings so as to protect a user from the sharp tip of the medical needle.

Abstract: A biosensor for monitoring one or more metabolites within a base fluid includes at least one working electrode having an inert conductive layer, a catalyst layer deposited over the inert conductive layer comprising a nanocomposite through which hydrogen peroxide may be adsorbed, an enzyme layer deposited over the catalyst layer comprising one or more enzymes selected to perform a redox reaction towards one or more metabolites, and a binder membrane providing supporting structure to the inert conductive layer, the catalyst layer, and the enzyme layer, the binder membrane selectively allowing molecules having a weight or size below a threshold from passing therethrough. The biosensor also includes an electrical interface in electrical communication with the inert conductive layer and configured to receive an electrical signal indicative of metabolites from the working electrode resulting from a biochemical reaction at or generated by one or more of the layers.

Abstract: Devices for protecting a user from a sharp tip of a medical needle includes a central body portion, a medical needle having a sharp tip, a pair of wings in attachment to the central body portion. The medical needle includes a longitudinal axis that is substantially perpendicular to at least one of a long axis of the central body portion and the delivery tube. The pair of wings are selectively positionable in a first position in which the pair of wings are spaced apart from the medical needle and a second position in which the pair of wings are proximate the medical needle. A mechanical fastener is disposed on at least one of the pair of wings, the mechanical fastener configured to selectively attach the pair of wings together in the second position with the medical needle positioned therebetween. Methods of using the device including administering medicinal fluids.

Abstract: Devices for protecting a user from a sharp tip of a medical needle includes a central body portion, a medical needle having a sharp tip, a pair of wings in attachment to the central body portion. The medical needle includes a longitudinal axis that is substantially perpendicular to at least one of a long axis of the central body portion and the delivery tube. The pair of wings are selectively positionable in a first position in which the pair of wings are spaced apart from the medical needle and a second position in which the pair of wings are proximate the medical needle. A mechanical fastener is disposed on at least one of the pair of wings, the mechanical fastener configured to selectively attach the pair of wings together in the second position with the medical needle positioned therebetween. Methods of using the device including administering medicinal fluids.

Abstract: Devices and methods for protecting a user from a sharp tip of a medical needle include a pair of wings in attachment to the central body portion to protect a user from the sharp tip of the medical needle. The method includes withdrawing a sharp tip of a medical needle from a patient and closing a pair of wings with the medical needle positioned between the wings so as to protect a user from the sharp tip of the medical needle.

Abstract: A system for delivering a medicinal fluid to a patient includes a variable volume pressure delivery chamber, a variable volume medication chamber, an optional medication reservoir, a movable delivery element, a fixed reference volume chamber, a pressure source, and a control sub-system. The variable volume pressure delivery chamber is configured to store pressure controllably. The variable volume medication chamber is fluidically isolated from the pressure delivery chamber and is configured to store medicinal fluid. The movable delivery element is disposed between the medication chamber and the pressure delivery chamber. The pressure source is coupled to the pressure delivery chamber.

Abstract: Described herein are systems and methods that allow for secure wireless communication between a contact lens system and an accessory device to protect sensitive data and prevent unauthorized access to confidential information. In certain embodiments, tampering attempts by potential attackers are thwarted by using a Physically Unclonable Functions (PUF) circuit that is immune to reverse engineering. In addition, sensors monitor a to-be-protected electronic device to detect tampering attempts and physical attacks to ensure the physical integrity of the communication system.

Abstract: A system for delivering a medicinal fluid to a patient includes a variable volume pressure delivery chamber, a variable volume medication chamber, an optional medication reservoir, a movable delivery element, a fixed reference volume chamber, a pressure source, and a control sub-system. The variable volume pressure delivery chamber is configured to store pressure controllably. The variable volume medication chamber is fluidically isolated from the pressure delivery chamber and is configured to store medicinal fluid. The movable delivery element is disposed between the medication chamber and the pressure delivery chamber. The pressure source is coupled to the pressure delivery chamber.

Abstract: A device, system and method are provided for controlling the rate of infusion of fluids during infusion therapy using non-electric infusion devices. Rotation of a flow regulator dial causes an orifice connected to the inlet to modify its position relative to a particular one or more orifices or groove portions, the characteristics of which provide a certain flow rate characteristic. The flow regulator allows for the infusion pump to infuse at a rate that may be varied during use by the user. Additionally, the flow regulator is made from a material selected to operate under a wide range of pressures, from 5-40 PSI, making the flow regulator compatible with pressurized devices, such as, a non-electric pump.

Abstract: A device, system and method are provided for controlling the rate of infusion of fluids during infusion therapy using non-electric infusion devices. Rotation of a flow regulator dial causes an orifice connected to the inlet to modify its position relative to a particular one or more orifices or groove portions, the characteristics of which provide a certain flow rate characteristic. The flow regulator allows for the infusion pump to infuse at a rate that may be varied during use by the user. Additionally, the flow regulator is made from a material selected to operate under a wide range of pressures, from 5-40 PSI, making the flow regulator compatible with pressurized devices, such as, a non-electric pump.