Abstract: An apparatus useful for moving a load. The apparatus includes a carriage with two frames, each one has a hinge end. The frames are hingeably connected to each other at the hinge end. One frame is mounted on a rail to move the carriage therealong. The other frame is moveable relative to the first frame about the hinge end. A jack assembly is connected to the frames and is actuatable to move one frame relative to the other frame about the hinge end. A brake assembly is located away from the hinge end and has a brake plate member connected to one frame for resilient axial movement. The brake assembly also has a brake plate stopper connected to the first frame, and is moveable between a carriage stopping configuration, in which the brake plate stopper engages the brake plate member, and a carriage moving configuration in which the brake plate stopper is retracted away from the brake plate member.

Abstract: The present invention is directed to preventing the consequences of the misfolding of proteins, such as those associated with protein folding diseases. Provided are methods of treatment that involve administering an agent that decreases the level of the heat shock protein ATPase Aha1 and/or related molecules with similar function. Such methods can result in the rescue of folding, trafficking, and function of proteins with suboptimal folding kinetics.