Abstract: The present disclosure provides creatine prodrug analogs and their compositions useful for the treatment of creatine deficiencies.

Abstract: The present invention is directed to preventing the consequences of the misfolding of proteins, such as those associated with protein folding diseases. Provided are methods of treatment that involve administering an agent that decreases the level of the heat shock protein ATPase Aha1 and/or related molecules with similar function. Such methods can result in the rescue of folding, trafficking, and function of proteins with suboptimal folding kinetics.

Abstract: A bottle assembly for storing and retailing a liquid substance such as fabric bleach that generates gases when it is heated or contaminated. The bottle of the assembly has a neck on which a closure cap may be screwed. The neck is closed by a peelable seal made of porous plastic foam such as polystyrene, which is fixed by a pressure adhesive across the neck and sized so as to be easily graspable and peelable with two fingers with a reduced risk of contact with the substance within the bottle. Another seal made of the same porous foam is freely mounted within the cap to allow the bottle to be sealed again in a permanent manner after the peelable seal has been removed. Both seals prevents the bottle from bulging and from leaking if it is inadvertantly knocked over.