Abstract: A system for diagnosing a heart condition comprises an imaging system (102) arranged to acquire two images of the heart at respective points in the cardiac cycle, and locating means, which may be manually operated or automatic, for locating a series of pairs of points on the images. Each pair of points indicates the respective positions of a single part of the heart in the two images. The system further comprises a processor (108) arranged to calculate from the positions of said pairs of points a value of at least one parameter of the deformation of the heart. It may further be arranged to compare the value of the at least one parameter with reference data to generate a diagnostic output.

Abstract: A system for diagnosing a heart condition comprises an imaging system (102) arranged to acquire two images of the heart at respective points in the cardiac cycle, and locating means, which may be manually operated or automatic, for locating a series of pairs of points on the images. Each pair of points indicates the respective positions of a single part of the heart in the two images. The system further comprises a processor (108) arranged to calculate from the positions of said pairs of points a value of at least one parameter of the deformation of the heart. It may further be arranged to compare the value of the at least one parameter with reference data to generate a diagnostic output.

Abstract: The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R1 is a saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include cyclic groups, wherein the hydrocarbyl group may optionally be substituted, and wherein the hydrocarbyl group may optionally include one or more heteroatoms N, O or S in its carbon skeleton; and R2 is a cyclic group substituted at the a-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Abstract: The present disclosure relates to a system (100) for scoring motion of a heart wall (214, 218). The system (100) includes an imaging system (102) operable to acquire a first image (230) of the heart wall (214, 218) at a first time and a second image (240) of the heart wall (214, 218) at a second time. A processor (108) is provided to identify a first set of contour data in the first image (230); and a second set of contour data in the second image (240). The processor (108) defines at least one element (Ei) representing a cardiac cyclic change in a section of the heart wall (214, 218) in dependence on the first and second sets of contour data. Each element (Ei) is analysed to generate at least one metric which is compared with a reference data model to score the motion of the corresponding section of the heart wall (214, 218). The disclosure also relates to a method of scoring motion of a heart wall (214, 218); and a non-transitory computer-readable medium.

Abstract: The present disclosure relates to a system (100) for scoring motion of a heart wall (214, 218). The system (100) includes an imaging system (102) operable to acquire a first image (230) of the heart wall (214, 218) at a first time and a second image (240) of the heart wall (214, 218) at a second time. A processor (108) is provided to identify a first set of contour data in the first image (230); and a second set of contour data in the second image (240). The processor (108) defines at least one element (Ei) representing a cardiac cyclic change in a section of the heart wall (214, 218) in dependence on the first and second sets of contour data. Each element (Ei) is analysed to generate at least one metric which is compared with a reference data model to score the motion of the corresponding section of the heart wall (214, 218). The disclosure also relates to a method of scoring motion of a heart wall (214, 218); and a non-transitory computer-readable medium.

Abstract: A system for diagnosing a heart condition comprises an imaging system (102) arranged to acquire two images of the heart at respective points in the cardiac cycle, and locating means, which may be manually operated or automatic, for locating a series of pairs of points on the images. Each pair of points indicates the respective positions of a single part of the heart in the two images. The system further comprises a processor (108) arranged to calculate from the positions of said pairs of points a value of at least one parameter of the deformation of the heart. It may further be arranged to compare the value of the at least one parameter with reference data to generate a diagnostic output.

Abstract: A system for diagnosing a heart condition comprises an imaging system (102) arranged to acquire two images of the heart at respective points in the cardiac cycle, and locating means, which may be manually operated or automatic, for locating a series of pairs of points on the images. Each pair of points indicates the respective positions of a single part of the heart in the two images. The system further comprises a processor (108) arranged to calculate from the positions of said pairs of points a value of at least one parameter of the deformation of the heart. It may further be arranged to compare the value of the at least one parameter with reference data to generate a diagnostic output.

Abstract: The present disclosure relates to a system (100) for generating a diagnostic model. The system (100) includes a processor (108) configured to analyse a plurality of reference data sets. The reference data sets each include at least one image (230, 240). The analysis identities at least one feature in each image (230, 240). A metric is calculated in dependence on the at least one identified feature. Outcome data associated with at least some of the reference data sets is acquired. The diagnostic model is compiled in dependence on the at least one calculated metric and the associated outcome data. The present disclosure also relates to a method of generating a diagnostic model; and a non-transitory computer-readable medium.

Abstract: The present disclosure relates to a system (100) for scoring motion of a heart wall (214, 218). The system (100) includes an imaging system (102) operable to acquire a first image (230) of the heart wall (214, 218) at a first time and a second image (240) of the heart wall (214, 218) at a second time. A processor (108) is provided to identify a first set of contour data in the first image (230); and a second set of contour data in the second image (240). The processor (108) defines at least one element (Ei) representing a cardiac cyclic change in a section of the heart wall (214, 218) in dependence on the first and second sets of contour data. Each element (Ei) is analysed to generate at least one metric which is compared with a reference data model to score the motion of the corresponding section of the heart wall (214, 218). The disclosure also relates to a method of scoring motion of a heart wall (214, 218); and a non-transitory computer-readable medium.

Abstract: The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R1 is a saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include cyclic groups, wherein the hydrocarbyl group may optionally be substituted, and wherein the hydrocarbyl group may optionally include one or more heteroatoms N, O or S in its carbon skeleton; and R2 is a cyclic group substituted at the ?-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Abstract: A system for diagnosing a heart condition comprises an imaging system (102) arranged to acquire two images of the heart at respective points in the cardiac cycle, and locating means, which may be manually operated or automatic, for locating a series of pairs of points on the images. Each pair of points indicates the respective positions of a single part of the heart in the two images. The system further comprises a processor (108) arranged to calculate from the positions of said pairs of points a value of at least one parameter of the deformation of the heart. It may further be arranged to compare the value of the at least one parameter with reference data to generate a diagnostic output.

Abstract: 4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, and their pharmaceutically acceptable salts, are potent specific antagonists of N-methyl-D-aspartate (NMDA) receptors and are therefore useful in the treatment of neurodegenerative disorders. 4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, other than carboxy or C.sub.1-6 alkoxycarbonyl, are novel compounds, as also are compounds of formula II ##STR1## wherein R.sup.2 represents carboxy or a group convertible thereto in vivo, R.sup.6 is hydrogen and R.sup.5 and R.sup.7 represent C.sub.1-6 alkyl or halogen, provided that R.sup.5 and R.sup.7 are not simultaneously chlorine or simultaneously bromine; a process for preparing the novel compounds is described, as also are pharmaceutical compositions containing the novel compounds.