Patents by Inventor Paul Leibowitz

Paul Leibowitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Extraction of granulocyte macrophage colony stimulating factor from bacteria
    Patent number: 5136024
    Abstract: A method of extracting granulocyte/macrophage colony stimulating factor (GM-CSF) from GM-SCF-expressing bacterial cells comprising treating a suspension of GM-CSF-containing bacterial cells with an acid and an enhancing agent, or with an acid that is itself an enhancing agent, removing substantially all of the suspension liquid from the cells, preparing a second suspension of the acidified cells, neutralizing said second suspension, and separating the GM-CSF-containing liquid from the suspended cells.
    Type: Grant
    Filed: October 18, 1989
    Date of Patent: August 4, 1992
    Assignee: Schering Corporation
    Inventors: Paul Leibowitz, Yair Alroy
  • Extraction of human interleukin-4- from bacteria
    Patent number: 4958007
    Abstract: A method is provided for extracting human interleukin-4 (IL-4) from IL-4 expressing bacterial cells. The method comprises treating the bacterial cells with a deactivating agent, disrupting the cell membrane and recovering the IL-4.
    Type: Grant
    Filed: May 17, 1988
    Date of Patent: September 18, 1990
    Assignee: Schering-Plough Corp.
    Inventors: Yair Alroy, Paul Leibowitz
  • Extraction of granulocyte macrophage colony stimulating factor from bacteria
    Patent number: 4912200
    Abstract: A method of extracting granulocyte macrophage colony stimulating factor (GM-CSF) from GM-CSF-expressing bacterial cells comprising treating a suspension of GM-CSF-containing bacterial cells with an acid and an enhancing agent, removing substantially all of the suspension liquid from the cells, preparing a second suspension of the acidified cells, neutralizing said second suspension, and separating the GM-CSF containing liquid from the suspended cells.
    Type: Grant
    Filed: May 11, 1987
    Date of Patent: March 27, 1990
    Assignee: Schering Corporation
    Inventors: Paul Leibowitz, Yair Alroy
  • Extraction of interferon from bacteria
    Patent number: 4364863
    Abstract: A method of extracting leucocyte interferon from interferon-expressing bacterial cells comprising acidifying a suspension of interferon-containing bacterial cells, removing substantially all of the suspension liquid from the cells, preparing a second suspension of the acidified cells, neutralizing said second suspension, separating the interferon containing liquid from the suspended cells, and extracting the interferon from said liquid.
    Type: Grant
    Filed: February 2, 1982
    Date of Patent: December 21, 1982
    Assignee: Schering Corporation
    Inventors: Paul Leibowitz, Marvin J. Weinstein
  • Extraction of interferon from bacteria
    Patent number: 4315852
    Abstract: A method of extracting leucocyte interferon from interferon-expressing bacterial cells comprising acidifying a suspension of interferon-containing bacterial cells, removing substantially all of the suspension liquid from the cells, preparing a second suspension of the acidified cells, neutralizing said second suspension, separating the interferon containing liquid from the suspended cells, and extracting the interferon from said liquid.
    Type: Grant
    Filed: December 29, 1980
    Date of Patent: February 16, 1982
    Assignee: Schering Corporation
    Inventors: Paul Leibowitz, Marvin J. Weinstein