Patents by Inventor Paul Li

Paul Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10538533
    Abstract: The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, L1, L2, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: January 21, 2020
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Indu T. Bharathan, Chris Blackburn, Jeffrey P. Ciavarri, Jouhara Chouitar, Courtney A. Cullis, Natalie D'Amore, Paul E. Fleming, Kenneth M. Gigstad, Krista E. Gipson, Mario Girard, Yongbo Hu, Janice Lee, Gang Li, Mansoureh Rezaei, Michael D. Sintchak, Francois Soucy, Stephen G. Stroud, Tricia J. Vos, Tzu-Tshin Wong, He Xu, Tianlin Xu, Yingchun Ye
  • Patent number: 10533052
    Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: January 14, 2020
    Assignee: Bristol-Myers Squibb Company
    Inventors: Xiao Min Schebye, Mark J. Selby, Michelle Minhua Han, Christine Bee, Andy X. Deng, Anan Chuntharapai, Brigitte Devaux, Huiming Li, Paul O. Sheppard, Alan J. Korman, Daniel F. Ardourel, Ekaterina Deyanova, Richard Huang, Guodong Chen, Michelle Kuhne, Hong-An Truong
  • Publication number: 20200014086
    Abstract: A vehicle having a communication system is disclosed. The system includes two electrical couplings, coupled by way of a rotary joint having a bearing waveguide. Each electrical coupling includes an interface waveguide configured to couple to external signals. Each electrical coupling also includes a waveguide section configured to propagate electromagnetic signals between the interface waveguide and the bearing waveguide of the rotary joint. Additionally, the rotary joint is configured to allow one electrical coupling to rotate with respect to the other electrical coupling. An axis of rotation of the rotary joint is defined by a center of a portion of the waveguides. Yet further, the rotary joint allows electromagnetic energy to propagate between the waveguides of the electrical couplings.
    Type: Application
    Filed: August 6, 2019
    Publication date: January 9, 2020
    Inventors: Zhe Li, Jamal Izadian, Pierre-yves Droz, Min Wang, Samuel Lenius, Paul Karplus, Kyla Purvis
  • Patent number: 10524470
    Abstract: Peroxyformic acid compositions for treatment and removal of biofilm growth and mineral deposits on membranes for energy services applications are disclosed. In particular, peroxyformic acid compositions are generated in situ or on site generation for the reduction and prevention, of biofilms and the mitigation of mineral buildup on the membranes. The compositions according to the invention are compatible with the membranes under application of use conditions.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: January 7, 2020
    Assignee: Ecolab USA Inc.
    Inventors: Junzhong Li, Cynthia Bunders, Richard Staub, Paul Frazer Schacht, Caleb Power, Ramakrishnan Balasubramanian, Robert J. Ryther, Catherine Hanson
  • Patent number: 10531406
    Abstract: Management of context and power control information enables different power control schemes for point-to-point or point-to-multipoint based on proximity services or applications. Context information may be defined as situation data about a service or application that is used to help define a power control scheme to be implemented. Power control information may be defined as control or status data for power control, which can be used for reporting or controlling the transmitting power of a peer in a P2P network. Context and power control information may be managed across multiple layers such as the application layer, service layer, media access control layer, or physical layer. Context and power control information is updated and exchanged between or among peers for context-related power control in proximity services.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: January 7, 2020
    Assignee: Convida Wireless, LLC
    Inventors: Qing Li, Paul L. Russell, Jr., Chonggang Wang, Zongrui Ding, Hongkun Li
  • Publication number: 20200000789
    Abstract: Vacuole- or exosome-inducing indole-based chalcone and substituted triazole-hydrazone compounds that induce endosomal vacuolization and increase exosome yield, but do not trigger growth arrest or cell death, and methods of making and using are described.
    Type: Application
    Filed: January 31, 2018
    Publication date: January 2, 2020
    Applicant: The University of Toledo
    Inventors: William A. Maltese, Zehui Li, Christopher J. Trabbic, Paul W. Erhardt
  • Publication number: 20200000090
    Abstract: Peroxyformic acid compositions for treatment and removal of biofilm growth and mineral deposits on membranes for energy services applications are disclosed. In particular, peroxyformic acid compositions are generated in situ or on site generation for the reduction and prevention, of biofilms and the mitigation of mineral buildup on the membranes. The compositions according to the invention are compatible with the membranes under application of use conditions.
    Type: Application
    Filed: September 4, 2019
    Publication date: January 2, 2020
    Inventors: Junzhong Li, Cynthia Bunders, Richard Staub, Paul Frazer Schacht, Caleb Power, Ramakrishnan Balasubramanian, Robert J. Ryther, Catherine Hanson
  • Patent number: 10516812
    Abstract: Techniques for selective display frame fetching can include receiving or fetching rendered display frames by a display engine. The display engine can determine if a new frame includes one or more dirty portions. If the new frame includes one or more dirty portions, just the dirty portions can be loaded by the display engine into a display buffer. The display engine can also scan out just the dirty portions from the display buffer to a display.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: December 24, 2019
    Assignee: Intel Corporation
    Inventors: Jason Tanner, Paul Diefenbaugh, Vishal Sinha, Arthur Runyan, Gary K. Smith, Kathy Bui, Yifan Li, Shirley Huang Meterelliyoz
  • Publication number: 20190381064
    Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.
    Type: Application
    Filed: August 22, 2019
    Publication date: December 19, 2019
    Applicant: AMGEN INC.
    Inventors: Paul E. HARRINGTON, Kate ASHTON, Sean P. BROWN, Matthew R. KALLER, Todd J. KOHN, Brian Alan LANMAN, Kexue LI, Yunxiao LI, Jonathan D. LOW, Ana Elena MINATTI, Alexander J. PICKRELL, Markian M. STEC, Joshua TAYGERLY
  • Publication number: 20190382836
    Abstract: This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries of beads attached to large numbers of oligonucleotides containing barcodes. Often, the beads provides herein are degradable. For example, they may contain disulfide bonds that are susceptible to reducing agents. The methods provided herein include methods of making libraries of barcoded beads as well as methods of combining the beads with a sample, such as by using a microfluidic device.
    Type: Application
    Filed: April 25, 2019
    Publication date: December 19, 2019
    Inventors: Christopher Hindson, Michael Schnall-Levin, Andrew Price, Paul Hardenbol, Yuan Li
  • Publication number: 20190378754
    Abstract: Described are methods for controlling the doping of metal nitride films such as TaN, TiN and MnN. The temperature during deposition of the metal nitride film may be controlled to provide a film density that permits a desired amount of doping. Dopants may include Ru, Cu, Co, Mn, Mo, Al, Mg, Cr, Nb, Ta, Ti and V. The metal nitride film may optionally be exposed to plasma treatment after doping.
    Type: Application
    Filed: August 20, 2019
    Publication date: December 12, 2019
    Inventors: Annamalai Lakshmanan, Ben-Li Sheu, Guodan Wei, Nicole Lundy, Paul F. Ma
  • Patent number: 10501439
    Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: December 10, 2019
    Assignee: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Paul S. Charifson, Kevin Michael Cottrell, Hongbo Deng, John P. Duffy, Huai Gao, Simon Giroux, Jeremy Green, Katrina Lee Jackson, Joseph M. Kennedy, David J. Lauffer, Mark Willem Ledeboer, Pan Li, John Patrick Maxwell, Mark A. Morris, Albert Charles Pierce, Nathan D. Waal, Jinwang Xu
  • Publication number: 20190366292
    Abstract: Disclosed herein is a substrate which includes a functional group protected with a photolabile group covalently attached to the substrate and a film of solvent thereof covering the substrate, where the thickness of the film is less than about 100 ?m. Also disclosed herein are methods of preparing such substrates. Further disclosed are methods of synthesizing polymers, methods of synthesizing arrays of polymers and methods of removing photolabile protecting groups. These methods all employ covering the substrate with a thin film of solvent where the thickness of the film is less than 100 ?m.
    Type: Application
    Filed: May 29, 2019
    Publication date: December 5, 2019
    Inventors: Glenn McGall, Darren Crandall, Bolan Li, Paul Dentinger
  • Patent number: 10498229
    Abstract: A method to soft start a charge pump circuit according to embodiments includes enabling switching for a plurality of power transistors, selecting a first switching control signal from a plurality of switching control signals for the selected plurality of power transistors, slowly ramping up a plurality of bootstrap supply voltages associated with the selected plurality of power transistors, driving a gate-to-source voltage of each power transistor of the selected plurality of power transistors at a first predefined level, and determining if the plurality of bootstrap supply voltages are less than a second predefined level. If the plurality of bootstrap supply voltages are less than the second predefined level, the method further includes toggling and thereby selecting a second switching control signal from the plurality of switching control signals for a second selected plurality of power transistors.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: December 3, 2019
    Assignee: Intersil Americas LLC
    Inventors: Eric Magne Solie, Mehul Shah, Bin Li, Paul K. Sferrazza
  • Patent number: 10493733
    Abstract: This disclosure relates to films particularly suitable for stretch hood applications. More particularly, this disclosure relates to multi-layer films particularly suitable for stretch hood applications comprising an inner layer that includes a blend of a propylene-based elastomer and a polyethylene having long-chain branching.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: December 3, 2019
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Paul M. German, Jr., Wen Li, Jianya Cheng
  • Patent number: 10496164
    Abstract: An electronic device may have a display. Input-output circuitry in the electronic device may be used to gather input from a viewer of the display. The input-output circuitry may include a gaze tracking system that gathers point-of-gaze information, vergence information, and head position information, may be a biometric sensor, may be an input device such as a button or touch sensor, may capture hand gestures, and/or may gather other information. The display may include a pixel array for producing images. An adjustable reflectance and transmittance layer may overlap the pixel array. Control circuitry in the electronic device may individually adjust different areas of the adjustable reflectance and transmittance layer. The control circuitry may place each area in a reflective mirror more or in a content-displaying mode and may move the areas in response to the information.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: December 3, 2019
    Assignee: Apple Inc.
    Inventors: Paul V. Johnson, Yuan Chen, Bryan W. Posner, Cheng Chen, Chia Hsuan Tai, Jiaying Wu, Robert Y. Cao, Shih-Chyuan Fan Jiang, Shih-Wei Chang, Xiaokai Li, Zhibing Ge, Dinesh C. Mathew
  • Publication number: 20190359668
    Abstract: The invention relates to a polypeptide selected from bone morphogenetic protein 10 (BMP10), or a bone morphogenetic protein 9 (BMP9) variant lacking osteogenic activity, for use in the treatment of a vascular disease or a respiratory disease. The invention also relates to novel BMP9 variants and to pharmaceutical compositions comprising said polypeptides.
    Type: Application
    Filed: May 17, 2019
    Publication date: November 28, 2019
    Applicant: CAMBRIDGE ENTERPRISE LIMITED
    Inventors: Nicholas W. Morrell, Wei Li, Paul D Upton
  • Publication number: 20190359808
    Abstract: A moisture curable polymer formulation comprising a (hydrolyzable silyl group)-functional polyolefin prepolymer, an acidic condensation catalyst, and a secondary diarylamine. A method of making the formulation; a moisture-cured polyolefin composition prepared therefrom; a manufactured article comprising or made from the formulation; and a method of using the manufactured article.
    Type: Application
    Filed: September 20, 2017
    Publication date: November 28, 2019
    Inventors: Dachao Li, Manish Talreja, Jeffrey M. Cogen, Timothy J. Person, Paul J. Caronia
  • Publication number: 20190345165
    Abstract: Compounds of Formula (IA), or a pharmaceutically acceptable salt thereof, and methods of use as Janus kinase inhibitors are described herein.
    Type: Application
    Filed: June 25, 2019
    Publication date: November 14, 2019
    Applicant: Genentech, Inc.
    Inventors: F. Anthony ROMERO, Mark ZAK, Guiling ZHAO, Paul GIBBONS, Wei LI, Yun-Xing CHENG, Po-Wai YUEN, Limin CHENG
  • Patent number: D867310
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: November 19, 2019
    Assignee: Raffel Systems, LLC
    Inventors: Paul Li, Kenneth G. Seidl