Patents by Inventor Paul Ling-Fung TANG

Paul Ling-Fung TANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR DETECTING RARE SEQUENCE VARIANTS
    Publication number: 20230416819
    Abstract: In some aspects, the present disclosure provides methods for identifying sequence variants in a nucleic acid sample. In some embodiments, a method comprises identifying sequence differences between sequencing reads and a reference sequence, and calling a sequence difference that occurs in at least two different circular polynucleotides, such as two circular polynucleotides having different junctions, as the sequence variant. In some aspects, the present disclosure provides compositions and systems useful in the described methods.
    Type: Application
    Filed: February 3, 2023
    Publication date: December 28, 2023
    Inventors: Shengrong LIN, Zhaohui SUN, Grace Qizhi ZHAO, Paul Ling-Fung TANG
  • Compositions and methods for detecting rare sequence variants
    Patent number: 11597973
    Abstract: In some aspects, the present disclosure provides methods for identifying sequence variants in a nucleic acid sample. In some embodiments, a method comprises identifying sequence differences between sequencing reads and a reference sequence, and calling a sequence difference that occurs in at least two different circular polynucleotides, such as two circular polynucleotides having different junctions, as the sequence variant. In some aspects, the present disclosure provides compositions and systems useful in the described methods.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: March 7, 2023
    Assignee: ACCURAGEN HOLDINGS LIMITED
    Inventor: Paul Ling-Fung Tang
  • COMPOSITIONS AND METHODS FOR DIGITAL POLYMERASE CHAIN REACTION
    Publication number: 20210301328
    Abstract: In some aspects, the present disclosure provides methods for identifying sequence variants in a nucleic acid sample. In some embodiments, a method comprises distinguishing between a true mutation in a polynucleotide and a random error introduced during an amplification step. In some embodiments, the methods reduce the number of false positives reported by a digital PCR assay. In some embodiments, the methods improve the accuracy of a digital PCR assay.
    Type: Application
    Filed: December 18, 2020
    Publication date: September 30, 2021
    Inventors: Li WENG, Malek FAHAM, Paul Ling-Fung TANG, Shengrong LIN
  • COMPOSITIONS AND METHODS FOR DETECTING RARE SEQUENCE VARIANTS
    Publication number: 20210054449
    Abstract: In some aspects, the present disclosure provides methods for identifying sequence variants in a nucleic acid sample. In some embodiments, a method comprises identifying sequence differences between sequencing reads and a reference sequence, and calling a sequence difference that occurs in at least two different circular polynucleotides, such as two circular polynucleotides having different junctions, as the sequence variant. In some aspects, the present disclosure provides compositions and systems useful in the described methods.
    Type: Application
    Filed: July 31, 2020
    Publication date: February 25, 2021
    Inventor: Paul Ling-Fung TANG
  • Compositions and methods for detecting rare sequence variants
    Patent number: 10767222
    Abstract: In some aspects, the present disclosure provides methods for identifying sequence variants in a nucleic acid sample. In some embodiments, a method comprises identifying sequence differences between sequencing reads and a reference sequence, and calling a sequence difference that occurs in at least two different circular polynucleotides, such as two circular polynucleotides having different junctions, as the sequence variant. In some aspects, the present disclosure provides compositions and systems useful in the described methods.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: September 8, 2020
    Assignee: ACCURAGEN HOLDINGS LIMITED
    Inventors: Shengrong Lin, Zhaohui Sun, Grace Qizhi Zhao, Paul Ling-Fung Tang
  • COMPOSITIONS AND METHODS FOR DETECTING RARE SEQUENCE VARIANTS
    Publication number: 20160304954
    Abstract: In some aspects, the present disclosure provides methods for identifying sequence variants in a nucleic acid sample. In some embodiments, a method comprises identifying sequence differences between sequencing reads and a reference sequence, and calling a sequence difference that occurs in at least two different circular polynucleotides, such as two circular polynucleotides having different junctions, as the sequence variant. In some aspects, the present disclosure provides compositions and systems useful in the described methods.
    Type: Application
    Filed: December 11, 2014
    Publication date: October 20, 2016
    Inventors: Shengrong LIN, Zhaohui SUN, Grace Qizhi ZHAO, Paul Ling-Fung TANG