Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.

Abstract: A method performed by a viewing device includes receiving a request for an operation to be performed by the viewing device. The request includes trigger criteria for performing the operation. The viewing device receives content from a content provider including content related metadata. A detection is made of a condition that the trigger criteria for the operation to be performed has been met. As a result, the viewing device performs the requested operation. The detection made be accomplished by the viewing device or by a service provider.

Abstract: Articles and devices comprising fluorinated polymers, as well as methods of preparing fluorinated polymers, are generally described. In some cases, such fluorinated elastomers can be used for sensing neural activity, e.g., by encapsulating electronic circuits, or other applications. Furthermore, according to certain embodiments, polymers can, surprisingly, be directly deposited onto layers comprising low molecular weight fluorinated polymers, e.g., without swelling in the presence of certain solvents. Some embodiments are generally directed to devices and methods for treating fluorinated polymers and subsequently depositing material onto the treated fluorinated polymers. This may allow the fabrication and patterning of multilayered articles comprising fluorinated elastomers.

Abstract: Neural network-based categorization can be improved by incorporating graph neural networks that operate on a graph representing the taxonomy of the categories into which a given input is to be categorized by the neural network based-categorization. The output of a graph neural network, operating on a graph representing the taxonomy of categories, can be combined with the output of a neural network operating upon the input to be categorized, such as through an interaction of multidimensional output data, such as a dot product of output vectors. In such a manner, information conveying the explicit relationships between categories, as defined by the taxonomy, can be incorporated into the categorization. To recapture information, incorporate new information, or reemphasize information a second neural network can also operate upon the input to be categorized, with the output of such a second neural network being merged with the output of the interaction.

Abstract: Techniques and apparatus for an interactive element presentation process are described. In one embodiment, for example, an apparatus may include logic operative to store a plurality of model specifications for computational models, monitor the object storage service for at least one model event using a first serverless computing service, provide the plurality of model specifications associated with the at least one model event to one of a plurality of serverless computing clusters, generate model data for each of the plurality of model specifications, store the model data for each of the plurality of computational models in the object storage service, monitor the object storage service for at least one data event associated with the model data using a second serverless computing service, cause the plurality of instances to generate a plurality of trained model specifications based on training of the plurality of computational models. Other embodiments are described.

Abstract: Disclosed are conjugate molecules formed from an active agent which is linked to a cannabinoid moiety through a specified linker having ester and amide end groups. The active agent can be a COX-2 inhibitor moiety, and the cannabinoid moiety can be a cannabidiol moiety. These conjugate molecules are contemplated to potentially be effective in the treatment of medical conditions.

Abstract: In one embodiment, a method for auditing the results of a machine learning model includes: retrieving a set of state estimates for original time series data values from a database under audit; reversing the state estimation computation for each of the state estimates to produce reconstituted time series data values for each of the state estimates; retrieving the original time series data values from the database under audit; comparing the original time series data values pairwise with the reconstituted time series data values to determine whether the original time series and reconstituted time series match; and generating a signal that the database under audit (i) has not been modified where the original time series and reconstituted time series match, and (ii) has been modified where the original time series and reconstituted time series do not match.

Abstract: In one embodiment, a method includes receiving a user request from a client system associated with a user, determining that the user request corresponds to a first suspended task, retrieving a first dialog state of the first suspended task from a dialog history associated with the user, generating a summary of the first suspended task based on the first dialog state using a natural-language generating (NLG) module, and sending instructions to the client system for providing the summary of the first suspended task to the user.

Abstract: Provided herein are targeting peptides and vectors containing a sequence that encodes the targeting peptides that deliver agents to specific substructures in the brain.

Abstract: Coating compositions comprise: a curable compound comprising: a core chosen from a C6 carbocyclic aromatic ring, a C2-5 heterocyclic aromatic ring, a C9-30 fused carbocyclic aromatic ring system, a C4-30 fused heterocyclic aromatic ring system, C1-20 aliphatic, and C3-20 cycloaliphatic, and three or more substituents of formula (1) wherein at least two substituents of formula (1) are attached to the aromatic core; provided that no substituents of formula (1) are in an ortho position to each other on the same aromatic ring of the core; a polymer; and one or more solvents, wherein the total solvent content is from 50 to 99 wt % based on the coating composition.

Abstract: The present invention is directed to binding molecules that possess one or more epitope-binding sites specific for an epitope of CD137 and one or more epitope-binding sites specific for an epitope of a tumor antigen (“TA”) (e.g., a “CD137×TA Binding Molecule”). In one embodiment, such CD137×TA Binding Molecules will be bispecific molecules, especially bispecific tetravalent diabodies, that are composed of two, three, four or more than four polypeptide chains and possessing two epitope-binding sites each specific for an epitope of CD137 and two epitope-binding sites each specific for an epitope of a TA. Alternatively, such CD137×TA Binding Molecules will be bispecific molecules, especially bispecific trivalent binding molecules composed of three or more polypeptide chains and possessing one or two epitope-binding sites each specific for an epitope of CD137 and one or two epitope-binding sites each specific for an epitope of a TA.

Abstract: Electronic devices may be provided with components such as displays and cameras. A display may be mounted in a housing. The housing may have a sidewall. A bent portion of the display may be embedded in epoxy that is separated from the sidewall by an air gap. Adhesive may attach the epoxy to the housing. A metal support that is chemically bonded to the epoxy may be welded to metal structures such as camera brackets and other metal supports. The housing may have a glass layer that forms a rear wall. The glass layer may have a protruding portion that forms a glass plateau with openings through which cameras operates. A camera may have a protruding portion that is received within one of the glass plateau openings. The protruding portion may extend into a metal camera trim in one of the openings that is attached to the glass plateau.

Abstract: Methods and devices for tissue fixation. A cortical button with a rib between two slotted openings. The rib increases the cortical button structural rigidity without increasing palpability. An adjustable loop construct with two discrete locking passages that provides manageable loop reduction and improved tissue coupling. The adjustable loop construct may be coupled to tissue via a passing construct. An assembly with a reduction bar, a button and an adjustable loop construct, the assembly provided assembled in a first configuration that disassembles to guide steps of tissue fixation. The reduction bar may be assembled to the reduction bar for reducing the adjustable loop construct.

Abstract: Systems and methods for media playback via a media playback system include (i) capturing a voice input comprising a request for media content, (ii) receiving information derived at least from the request for media content, (iii) requesting and receiving information from at least one remote computing device associated with a first media content service and at least one remote computing device associated with a second media content service, wherein (a) the information identifies first media content available via the first media content service for playback and identifies second media content available via the second media content service for playback, and (b) the first and second media content are related to the requested media content, and (iv) after receiving at least one of the first information and the second information, (a) selecting the first media content instead of the second media content, and (b) playing back the first media content.

Abstract: Various embodiments include methods for rotating a control node role among devices in a control cluster of a wireless mesh network. Methods may include assuming the control node role by a first device based on a control node assumption timing in a schedule, and transmitting periodic messages to support the wireless mesh network. Methods may further include using the schedule to identify a control node role end timing and a third device in the control cluster that will assume the control node role, transmitting the periodic messages while monitoring for an extended advertisement from the third device after the control node role end timing until the extended advertisement from the third device is received, and assuming a passive node role upon receiving the extended advertisement from the third device or continuing the control node role when no extended advertisement is received from the third device.

Abstract: An audio device with a body configured to be worn on or abutting an outer ear of a user, wherein the body is configured to contact at least one of the outer ear and the portion of the head that abuts the outer ear, at two separate spaced contact locations, and wherein the body is compliant at a body portion that defines one of the contact locations. The device also has an acoustic module carried by the body and configured to locate a sound-emitting opening anteriorly of and proximate the user's ear canal opening when the body is worn on or abutting the ear of the user.

Abstract: A system comprising at least one hardware processor for updating a cloud-based road anomaly database is disclosed, wherein the system receives information from a vehicle regarding an object detected by one or more sensors of the vehicle, the information may include a location and/or a size of the detected object; compares the location and/or the size of the first detected object against data stored in a road feature database regarding the first detected object; determines, based on comparing the location and/or the size, an accuracy score associated with the first detected object and the second detected object; and updates the cloud-based road anomaly database with the received information for the second detected object based on the associated accuracy score being higher than at least one of a threshold accuracy score or an accuracy score associated with corresponding object information stored in the cloud-based road anomaly database.

Abstract: Neural network-based categorization can be improved by incorporating graph neural networks that operate on a graph representing the taxonomy of the categories into which a given input is to be categorized by the neural network based-categorization. The output of a graph neural network, operating on a graph representing the taxonomy of categories, can be combined with the output of a neural network operating upon the input to be categorized, such as through an interaction of multidimensional output data, such as a dot product of output vectors. In such a manner, information conveying the explicit relationships between categories, as defined by the taxonomy, can be incorporated into the categorization. To recapture information, incorporate new information, or reemphasize information a second neural network can also operate upon the input to be categorized, with the output of such a second neural network being merged with the output of the interaction.

Abstract: Neural network-based categorization can be improved by incorporating graph neural networks that operate on a graph representing the taxonomy of the categories into which a given input is to be categorized by the neural network based-categorization. The output of a graph neural network, operating on a graph representing the taxonomy of categories, can be combined with the output of a neural network operating upon the input to be categorized, such as through an interaction of multidimensional output data, such as a dot product of output vectors. In such a manner, information conveying the explicit relationships between categories, as defined by the taxonomy, can be incorporated into the categorization. To recapture information, incorporate new information, or reemphasize information a second neural network can also operate upon the input to be categorized, with the output of such a second neural network being merged with the output of the interaction.

Abstract: Gel electrophoresis receptacles and methods of using such receptacles are provided. In one embodiment, a receptacle comprises a cavity for receiving an electrophoresis gel, wherein at least a portion of the receptacle is formed from cyclic olefin copolymer or cyclic olefin polymer.