Patents by Inventor Paul Lobben

Paul Lobben has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TETRAHYDROISOQUINOLINES AND INTERMEDIATES THEREFOR
    Publication number: 20150191494
    Abstract: Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form.
    Type: Application
    Filed: March 18, 2015
    Publication date: July 9, 2015
    Inventors: Paul Lobben, Rulin Zhao, Bei Wang, Bang-Chi Chen, Shuang Liu, Min Hu, Yuh-Lin Allen Yang, Matthew Isherwood, Rasidul Amin, Wenge Cui
  • Tetrahydroisoquinolines and intermediates therefor
    Patent number: 8420811
    Abstract: Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: April 16, 2013
    Assignees: Bristol-Myers Squibb Company, Albany Molecular Research, Inc.
    Inventors: Paul Lobben, Rulin Zhao, Bei Wang, Bang-Chi Chen, Shuang Liu, Min Hu, Yuh-Lin Allen Yang, Matthew Isherwood, Rasidul Amin, Wenge Cui
  • PROCESSES FOR PREPARING TETRAHYDROISOQUINOLINES
    Publication number: 20110077400
    Abstract: Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form.
    Type: Application
    Filed: June 4, 2009
    Publication date: March 31, 2011
    Inventors: Paul Lobben, Rulin Zhao, Bei Wang, Bang-Chi Chen, Shuang Liu, Min Hu, Yuh-Lin Allen Yang, Matthew Isherwood, Rasidul Amin, Wenge Cui
  • PROCESS FOR THE PREPARATION OF [(1R), 2S]-2-AMINOPROPIONIC ACID 2-[4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLO[2,1-f][1,2,4]TRIAZIN-6-YLOXY]-1-METHYLETHYL ESTER
    Publication number: 20070249610
    Abstract: The invention relates to an improved process for preparing [(1R),2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester of the formula: Compound I has been shown to be useful for the treatment of certain types of cancer.
    Type: Application
    Filed: April 20, 2007
    Publication date: October 25, 2007
    Inventors: Gerard Crispino, Mourad Hamedi, Thomas LaPorte, John Thornton, Jaan Pesti, Zhongmin Xu, Paul Lobben, David Leahy, Jale Muslehiddinoglu, Chiajen Lai, Lori Spangler, Robert Discordia
  • Methods for the preparation of pyrrolotriazine compounds
    Publication number: 20060030708
    Abstract: A method for preparing a compound having the formula: including the steps of: (a) cyclizing a compound of formula II: to form a compound of formula I: (b) deprotecting the nitrogen atom of the compound of formula I by amination or hydrogenation to form compound III.
    Type: Application
    Filed: August 5, 2005
    Publication date: February 9, 2006
    Inventor: Paul Lobben