Abstract: A biopsy device includes a cannula and a specimen collector. The cannula has a proximal end and a longitudinal axis. The specimen collector contains the proximal end of the cannula. The specimen collector has a removable sample receiving cartridge that is removable along the longitudinal axis of the cannula to expose the proximal end of the cannula.

Abstract: Devices, systems, and methods for sealing medical devices, particularly during intravascular access, are disclosed herein. Some aspects relate to a hemostatic valve for sealing a wide range of medical devices, such as catheters, wires, embolectomy systems. The valve can include an elongate member having a first end, a second end, and a central lumen extending therebetween. A reinforcement structure extends along at least a portion of the elongate member and is coupled to the elongate member. A shell defining a first aperture and a second aperture may be included, which first and second apertures can be fluidly coupled by the elongate member. A tensioning mechanism is coupled to the shell and to the elongate member, the tensioning mechanism can be moveable between a first configuration wherein the tensioning mechanism is collapsed and the central lumen is sealed and a second configuration wherein the central lumen is open.

Abstract: A biopsy device includes a tissue cutting member slidably disposed within a probe component. The tissue cutting member has a distal tubular portion having a longitudinal axis and a flared distal section. The flared distal section has an inclined distal tip and an outwardly flared distal tubular portion that defines an inner tissue receiving aperture. The inclined distal tip has a beveled front face with a leading tissue cutting edge and a trailing cutting edge. A longitudinally oriented opening is in the flared distal section. The longitudinally oriented opening has an open distal end and is configured to extend from a closed proximal end to the open distal end. The closed proximal end has a relief opening with a transverse dimension larger than a transverse dimension of the longitudinally oriented opening adjacent the relief opening. The longitudinally oriented opening diverges to intersect the trailing cutting edge.

Abstract: A system and method for managing an occlusion, such as a blood clot, within a lumen or passageway of a patient. More particularly, a system and method for rapidly restoring blood flow through an occlusion including a self-expanding, tubular member through which blood may flow when in an expanded state. The tubular member has a structure configured to engage the occlusive material, thereby allowing for extraction of at least a portion of the occlusive material. The system may further employ a material extraction member that is deployed distally of the tubular member.

Abstract: Devices, systems, and methods for sealing medical devices, particularly during intravascular access, are disclosed herein. Some aspects relate to a hemostatic valve for sealing a wide range of medical devices, such as catheters, wires, embolectomy systems. The valve can include an elongate member having a first end, a second end, and a central lumen extending therebetween. A reinforcement structure extends along at least a portion of the elongate member and is coupled to the elongate member. A shell defining a first aperture and a second aperture may be included, which first and second apertures can be fluidly coupled by the elongate member. A tensioning mechanism is coupled to the shell and to the elongate member, the tensioning mechanism can be moveable between a first configuration wherein the tensioning mechanism is collapsed and the central lumen is sealed and a second configuration wherein the central lumen is open.

Abstract: A biopsy device for accessing and collecting multiple tissue specimens includes a probe component and a drive component. The probe component includes a probe housing that fits within a housing cover, an elongated distal shaft with a tubular section proximal to a penetrating distal tip, an elongated tissue cutting member, and a first probe gear. The tubular section having an inner lumen, an open tissue receiving aperture, and a proximal extremity configured to be operatively connected to the drive component. The elongated distal shaft secured to the probe housing. The elongated tissue cutting member is slidably disposed within the tubular section. The elongated tissue cutting member having at least one tissue cutting edge and a cutting member inner lumen extending therein. The drive component has a first driver motor and a first driving gear configured to drive the first probe gear in order to orient the open tissue receiving aperture.

Abstract: A vascular occlusion device includes a braided filament mesh structure defining a longitudinal axis. The mesh structure has a relaxed configuration in which it has an axial array of radially-extending occlusion regions, each of which has a proximal side and a distal side meeting at a peripheral edge, the sides of each occlusion region forming a first angle relative to the longitudinal axis. Each occlusion region is axially separated from the adjacent occlusion region by a reduced-diameter connecting region. The mesh structure is radially compressible to a compressed state in which it is deployed intravascularly to a target site through a catheter. Upon deployment, the device radially expands to a constrained configuration in which the peripheral edges of the occlusion regions engage the vascular wall, and the sides of the occlusion regions form a second angle relative to the longitudinal axis that is smaller than the first angle.

Abstract: In a system and method for deployment of an implant device, the implant device includes a first loop at its proximal end, and a deployment tool has a second loop attached at its distal end. A release wire slidably disposed within the deployment tool has a distal end extending through the first and second loops to releasably couple the implant device to the deployment tool, and a proximal portion extending from a proximal end of the deployment tool, which is held in a retraction device. The retraction device is operable to hold the proximal end of the deployment tool and to pull the release wire proximally through the deployment tool until the distal end of the release wire is withdrawn from the first and second loops to decouple the implant device from the deployment tool.

Abstract: A biopsy device includes an elongated probe having a central longitudinal axis, a proximal end, and a distal end. A tissue penetrating tip includes a proximal base and a sharp distal point. The proximal base is secured to the distal end of the elongated probe. The sharp distal point is distal to the proximal base and is aligned with the central longitudinal axis. The tissue penetrating tip has a plurality of concave surfaces annularly arranged to form at least three adjacent pairs of concave surfaces. Each concave surface of the plurality of concave surfaces extends from the proximal base to the sharp distal point. Each adjacent pair of concave surfaces intersect to form a concave curved cutting edge. Cumulatively, the at least three adjacent pairs of concave surfaces form a plurality of concave curved cutting edges that distally terminate at the sharp distal point.

Abstract: A vascular occlusion device includes a braided filament mesh structure defining a longitudinal axis. The mesh structure has a relaxed configuration in which it has an axial array of radially-extending occlusion regions, each of which has a proximal side and a distal side meeting at a peripheral edge, the sides of each occlusion region forming a first angle relative to the longitudinal axis. Each occlusion region is axially separated from the adjacent occlusion region by a reduced-diameter connecting region. The mesh structure is radially compressible to a compressed state in which it is deployed intravascularly to a target site through a catheter. Upon deployment, the device radially expands to a constrained configuration in which the peripheral edges of the occlusion regions engage the vascular wall, and the sides of the occlusion regions form a second angle relative to the longitudinal axis that is smaller than the first angle.

Abstract: A device and method for intravascular treatment of an embolism, and particularly a pulmonary embolism, is disclosed herein. One aspect of the present technology, for example, is directed toward a clot treatment device that includes a support member having a plurality of first clot engagement members and second clot engagement members positioned about the circumference of a distal portion of the support member. In an undeployed state, individual first clot engagement members can be linear and have a first length, and individual second clot engagement members can be linear and have a second length that is less than the first length. The clot engagement members can be configured to penetrate clot material along an arcuate path and hold clot material to the clot treatment device.

Abstract: A method and apparatus for treating a clot in the blood vessel of a patient, and particularly the treatment of a pulmonary embolism is disclosed. The treatment includes restoring flow through the clot followed by clot removal, either partially or substantially completely. The clot treatment device is expandable into the blood vessel and may contain radial extensions that assist in restoring flow as well as in removing clot material.

Abstract: A system and method for managing an occlusion, such as a blood clot, within a lumen or passageway of a patient. More particularly, a system and method for rapidly restoring blood flow through an occlusion including a self-expanding, tubular member through which blood may flow when in an expanded state. The tubular member has a structure configured to engage the occlusive material, thereby allowing for extraction of at least a portion of the occlusive material. The system may further employ a material extraction member that is deployed distally of the tubular member.

Abstract: Devices, systems, and methods for sealing medical devices, particularly during intravascular access, are disclosed herein. Some aspects relate to a hemostatic valve for sealing a wide range of medical devices, such as catheters, wires, embolectomy systems. The valve can include an elongate member having a first end, a second end, and a central lumen extending therebetween. A reinforcement structure extends along at least a portion of the elongate member and is coupled to the elongate member. A shell defining a first aperture and a second aperture may be included, which first and second apertures can be fluidly coupled by the elongate member. A tensioning mechanism is coupled to the shell and to the elongate member, the tensioning mechanism can be moveable between a first configuration wherein the tensioning mechanism is collapsed and the central lumen is sealed and a second configuration wherein the central lumen is open.

Abstract: Systems and methods for removal of thrombus from a blood vessel in a body of a patient are disclosed herein. The method can include: providing a thrombus extraction device including a proximal self-expanding member formed of a fenestrated structure, a substantially cylindrical portion formed of a net-like filament mesh structure having a proximal end coupled to a distal end of the fenestrated structure; advancing a catheter constraining the thrombus extraction device through a vascular thrombus, deploying the thrombus extraction device by stacking a portion of the net-like filament mesh structure outside of the catheter by distally advancing the self-expanding member until the self-expanding member is beyond a distal end of the catheter; retracting the self-expanding member to unstack the portion of the net-like filament mesh structure and to capture the portion of the thrombus; and withdrawing the thrombus extraction device from the body.

Abstract: A device and method for intravascular treatment of an embolism, and particularly a pulmonary embolism, is disclosed herein. One aspect of the present technology, for example, is directed toward a clot treatment device that includes a support member having a plurality of first clot engagement members and second clot engagement members positioned about the circumference of a distal portion of the support member. In an undeployed state, individual first clot engagement members can be linear and have a first length, and individual second clot engagement members can be linear and have a second length that is less than the first length. The clot engagement members can be configured to penetrate clot material along an arcuate path and hold clot material to the clot treatment device.

Abstract: Devices, systems, and methods for sealing medical devices, particularly during intravascular access, are disclosed herein. Some aspects relate to a hemostatic valve for sealing a wide range of medical devices, such as catheters, wires, embolectomy systems. The valve can include an elongate member having a first end, a second end, and a central lumen extending therebetween. A reinforcement structure extends along at least a portion of the elongate member and is coupled to the elongate member. A shell defining a first aperture and a second aperture may be included, which first and second apertures can be fluidly coupled by the elongate member. A tensioning mechanism is coupled to the shell and to the elongate member, the tensioning mechanism can be moveable between a first configuration wherein the tensioning mechanism is collapsed and the central lumen is sealed and a second configuration wherein the central lumen is open.

Abstract: A screen providing a GUI is disclosed for a tissue biopsy system having a tissue cutting member. The screen includes a first GUI area configured to represent a first region of the target site from which at least one tissue specimen has been separated from tissue at the target site by the tissue cutting member. The screen further includes a second GUI area configured to represent a second region from which the tissue cutting member may separate one or more additional tissue specimens from tissue at the target site. The screen includes a third GUI area configured to represent a third region in which the tissue cutting member is deployed to separate a tissue specimen from tissue at the target site. The GUI is configured to update the first GUI area, the second GUI area, and the third GUI area as the tissue cutting member is rotated within the patient.

Abstract: Systems and methods for removal of thrombus from a blood vessel in a body of a patient are disclosed herein. The method can include: providing a thrombus extraction device including a proximal self-expanding member formed of a fenestrated structure, a substantially cylindrical portion formed of a net-like filament mesh structure having a proximal end coupled to a distal end of the fenestrated structure; advancing a catheter constraining the thrombus extraction device through a vascular thrombus, deploying the thrombus extraction device by stacking a portion of the net-like filament mesh structure outside of the catheter by distally advancing the self-expanding member until the self-expanding member is beyond a distal end of the catheter; retracting the self-expanding member to unstack the portion of the net-like filament mesh structure and to capture the portion of the thrombus; and withdrawing the thrombus extraction device from the body.

Abstract: A control console is disclosed for controlling one or more medical devices. The control console communicates to at least one medical device, and at least one peripheral module associated with the medical device if needed. The control console has a microprocessor for processing data to direct an operation of the medical device.