Patents by Inventor Paul Lyne

Paul Lyne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Humanized anti-LT-?-R antibodies
    Patent number: 7429644
    Abstract: Humanized antibodies to LT-?-R and methods of use thereof are provided.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: September 30, 2008
    Assignee: Biogen Idec MA Inc.
    Inventors: Ellen Garber, Paul Lyne, Jose William Saldanha
  • Substitute thiophenes and uses thereof
    Patent number: 7423061
    Abstract: This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical salts, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: September 9, 2008
    Assignee: AstraZeneca AB
    Inventors: Susan Ashwell, Thomas Gero, Stephanos Ioannidis, James Janetka, Paul Lyne, Vibha Oza, Stephanie Springer, Mei Su, Dingwei Yu
  • Quinoxalines as B Baf Inhhibitors
    Publication number: 20080207616
    Abstract: The invention relates to chemical compounds of the formula (I) or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.
    Type: Application
    Filed: October 13, 2005
    Publication date: August 28, 2008
    Applicant: AstraZeneca AB
    Inventors: Brian Aquila, Les Dakin, Tracy Deegan, Stephanos Ioannidis, Stephen Lee, Paul Lyne, Timothy Pontz, Mei Su
  • Chemical Compounds
    Publication number: 20080146570
    Abstract: The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof, of the formula (I): which possess B-Raf inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man.
    Type: Application
    Filed: January 24, 2006
    Publication date: June 19, 2008
    Applicant: ASTRAZENECA AB
    Inventors: Brian Aquila, Paul Lyne, Timothy Pontz
  • Pyrazolylaminopyridine Derivatives Useful as Kinases Inhibitors
    Publication number: 20080139561
    Abstract: This invention relates to novel compounds having the Formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
    Type: Application
    Filed: February 1, 2006
    Publication date: June 12, 2008
    Applicant: ASTRAZENECA AB
    Inventors: Audrey Davies, Michelle Lamb, Paul Lyne, Tao Wang, Dingwei Yu, Peter Mohr, Bin Wang
  • Azine-Carboxamides as Anti-Cancer Agents
    Publication number: 20070259849
    Abstract: The invention relates to chemical compounds, of the formula (I): or pharmaceutically acceptable salts thereof, which possess B-Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.
    Type: Application
    Filed: June 29, 2005
    Publication date: November 8, 2007
    Applicant: ASTRAZENECA AB
    Inventors: Brian Aquila, Stephanos Ioannidis, Paul Lyne, Timothy Pontz
  • Novel fused triazolones and the uses thereof
    Publication number: 20070149560
    Abstract: This invention relates to novel compounds having the structural diagram (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
    Type: Application
    Filed: March 10, 2004
    Publication date: June 28, 2007
    Applicant: AstraZeneca AB
    Inventors: Susan Ashwell, Jayachandran Ezhuthachan, Paul Lyne, Nicholas Newcombe, Martin Pass, Vibha Oza, Mei Su, Dorin Toader, Dingwei Yu, Yan Yu
  • Thiophene derivatives as chk 1 inhibitors
    Publication number: 20070010556
    Abstract: This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
    Type: Application
    Filed: December 24, 2004
    Publication date: January 11, 2007
    Applicant: ASTRAZENECA AB
    Inventors: Susan Ashwell, Thomas Gero, Stephanos Ioannidis, James Janetka, Paul Lyne, Su Mei, Doria Toader, Dingwei Yu, Yan Yu
  • Substitute thiophenes and uses therof
    Publication number: 20060281666
    Abstract: This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical salts, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
    Type: Application
    Filed: August 12, 2004
    Publication date: December 14, 2006
    Inventors: Susan Ashwell, Thomas Gero, Stephanos Ioannidis, James Janetka, Paul Lyne, Vibha Oza, Stephanie Springer, Mei Su, Dingwei Yu
  • Pyrazolopyridines and methods of making and using the same
    Publication number: 20060106033
    Abstract: Compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders.
    Type: Application
    Filed: September 5, 2003
    Publication date: May 18, 2006
    Inventors: Wen-Cherng Lee, Mary Carter, Lihong Sun, Claudio Chuaqui, Zhongli Zheng, Juswinder Singh, Paula Boriack-Sjodin, Paul Lyne
  • Humanized anti-LT-beta-R antibodies
    Publication number: 20040058394
    Abstract: Humanized antibodies to LT-&bgr;-R and methods of use thereof are provided.
    Type: Application
    Filed: April 10, 2003
    Publication date: March 25, 2004
    Inventors: Ellen Garber, Paul Lyne, Jose William Saldanha