Patents by Inventor Paul M. BOJCZUK

Paul M. BOJCZUK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-ICOS and anti-PD-1 antibody combination therapy
    Patent number: 11649289
    Abstract: The present invention provides methods for increasing expression of ICOS on an effector T cell comprising contacting said effector T cell with an anti-PD-1 antibody. The present invention also provides methods for decreasing expression of ICOS on a regulatory T cell comprising contacting said regulatory T cell with an anti-PD-1 antibody. The present invention provides methods for increasing sensitivity to an agent directed to ICOS in a human comprising administering to the human an anti-PD1 antibody. The present invention also provides methods of treating cancer in a human in need thereof comprising administering an anti-PD-1 antibody and an anti-ICOS antibody to said human, wherein the anti-PD-1 antibody increases T cell sensitivity to the ICOS antibody.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: May 16, 2023
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Sabyasachi Bhattacharya, Paul M. Bojczuk, Heather L. Jackson, Mili Mandal, Hong Shi, Sapna Yadavilli, Niranjan Yanamandra
  • ANTI-ICOS AND ANTI-PD-1 ANTIBODY COMBINATION THERAPY
    Publication number: 20190256599
    Abstract: The present invention provides methods for increasing expression of ICOS on an effector T cell comprising contacting said effector T cell with an anti-PD-1 antibody. The present invention also provides methods for decreasing expression of ICOS on a regulatory T cell comprising contacting said regulatory T cell with an anti-PD-1 antibody. The present invention provides methods for increasing sensitivity to an agent directed to ICOS in a human comprising administering to the human an anti-PD1 antibody. The present invention also provides methods of treating cancer in a human in need thereof comprising administering an anti-PD-1 antibody and an anti-ICOS antibody to said human, wherein the anti-PD-1 antibody increases T cell sensitivity to the ICOS antibody.
    Type: Application
    Filed: August 3, 2017
    Publication date: August 22, 2019
    Inventors: Sabyasachi BHATTACHARYA, Paul M. BOJCZUK, Heather L. JACKSON, Mili MANDAL, Hong SHI, Sapna YADAVILLI, Niranjan YANAMANDRA