Patents by Inventor Paul M. Dunman

Paul M. Dunman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical composition containing polymyxin B/trimethoprim based therapeutics
    Patent number: 11096923
    Abstract: The present invention features an antibacterial composition comprising 1) a composition A comprising polymyxin B and trimethoprim; and 2) an antibiotic agent selected from the group consisting of rifampicin, rifabutin, rifapentine, rifaximin, pefloxacin mesylate, sparfloxacin, sarafloxacin HCl, tobramycin, lomefloxacin, besifloxacin, danofloxacin mesylate, enrofloxacin, nadifloxacin and clinafloxacin, a topical pharmaceutical thereof, and a method of treating bacterial infections using mixtures of 1 and 2.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: August 24, 2021
    Assignee: University of Rochester
    Inventors: Paul M. Dunman, Rachel Wozniak
  • Prevention and treatment for microbial infections
    Patent number: 11065274
    Abstract: The present invention features a composition comprising zinc pyrithione and silver sulfiadizine, a formulation thereof and a method of treating microbial infection using the composition.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: July 20, 2021
    Assignee: University of Rochester
    Inventor: Paul M. Dunman
  • Antimicrobial compositions comprising mupirocin and neomycin
    Patent number: 10525032
    Abstract: The present invention features a composition comprising mupirocin and neomycin, a formulation thereof and a method of treating microbial infection using the composition.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: January 7, 2020
    Assignee: UNIVERSITY OF ROCHESTER
    Inventor: Paul M. Dunman
  • Small molecule efflux pump inhibitors
    Patent number: 10471028
    Abstract: Small molecule efflux pump inhibitors are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the small molecule efflux pump inhibitors to restore the antibiotic susceptibility of microbes.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: November 12, 2019
    Assignee: UNIVERSITY OF ROCHESTER
    Inventors: Paul M. Dunman, Catlyn E. Blanchard
  • Pharmaceutical Composition Containing Polymyxin B/Trimethoprim based Therapeutics
    Publication number: 20190175550
    Abstract: The present invention features an antibacterial composition comprising 1) a composition A comprising polymyxin B and trimethoprim; and 2) an antibiotic agent selected from the group consisting of rifampicin, rifabutin, rifapentine, rifaximin, pefloxacin mesylate, sparfloxacin, sarafloxacin HCl, tobramycin, lomefloxacin, besifloxacin, danofloxacin mesylate, enrofloxacin, nadifloxacin and clinafloxacin, a topical pharmaceutical thereof, and a method of treating bacterial infections using mixtures of 1 and 2.
    Type: Application
    Filed: August 16, 2017
    Publication date: June 13, 2019
    Inventors: Paul M. Dunman, Rachel Wozniak
  • PREVENTION AND TREATMENT FOR MICROBIAL INFECTIONS
    Publication number: 20180236000
    Abstract: The present invention features a composition comprising zinc pyrithione and silver sulfiadizine, a formulation thereof and a method of treating microbial infection using the composition.
    Type: Application
    Filed: July 26, 2016
    Publication date: August 23, 2018
    Inventor: Paul M. DUNMAN
  • Antimicrobial Compositions Comprising Mupirocin and Neomycin
    Publication number: 20180228760
    Abstract: The present invention features a composition comprising mupirocin and neomycin, a formulation thereof and a method of treating microbial infection using the composition.
    Type: Application
    Filed: August 3, 2016
    Publication date: August 16, 2018
    Inventor: Paul M. Dunman
  • Synergistic compositions for treating microbial infections
    Patent number: 10028931
    Abstract: Synergistic pharmaceutical compositions including an RNase P inhibitor and a tRNA synthetase inhibitor are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the compositions to inhibit a bacterial tRNA synthetase in a cell and to decolonize bacteria on a surface.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: July 24, 2018
    Assignees: University of Rochester, Temple University—Of the Commonwealth System of Higher Education
    Inventors: Paul M. Dunman, Wayne Childers
  • Methods and compositions for treating infection
    Patent number: 10004701
    Abstract: Provided herein are compositions and methods for treating or preventing infection.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: June 26, 2018
    Assignees: UNIVERSITY OF ROCHESTER, UNIVERSITY OF KANSAS
    Inventors: Paul M. Dunman, Damian J. Krysan, Daniel P. Flaherty
  • SYNERGISTIC COMPOSITIONS FOR TREATING MICROBIAL INFECTIONS
    Publication number: 20170246139
    Abstract: Synergistic pharmaceutical compositions including an RNase P inhibitor and a tRNA synthetase inhibitor are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the compositions to inhibit a bacterial tRNA synthetase in a cell and to decolonize bacteria on a surface.
    Type: Application
    Filed: October 30, 2015
    Publication date: August 31, 2017
    Applicants: UNIVERSITY OF ROCHESTER, TEMPLE UNIVERSITY -- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Paul M. Dunman, Wayne Childers
  • Small molecule RNase inhibitors and methods of use
    Patent number: 9693999
    Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: July 4, 2017
    Assignees: University of Rochester, Board of Regents of the University of Nebraska, Temple University—Of the Commonwealth System of Higher Education
    Inventors: Paul M. Dunman, Patrick D. Olson, Wayne Childers
  • SMALL MOLECULE EFFLUX PUMP INHIBITORS
    Publication number: 20170100414
    Abstract: Small molecule efflux pump inhibitors are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the small molecule efflux pump inhibitors to restore the antibiotic susceptibility of microbes.
    Type: Application
    Filed: June 12, 2015
    Publication date: April 13, 2017
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Paul M. Dunman, Catlyn E. Blanchard
  • METHODS AND COMPOSITIONS FOR TREATING INFECTION
    Publication number: 20170065540
    Abstract: Provided herein are compositions and methods for treating or preventing infection.
    Type: Application
    Filed: November 21, 2016
    Publication date: March 9, 2017
    Applicants: UNIVERSITY OF ROCHESTER, UNIVERSITY OF KANSAS
    Inventors: Paul M. Dunman, Damian J. Krysan, Daniel P. Flaherty
  • Small molecule RNase inhibitors and methods of use
    Patent number: 9517230
    Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: December 13, 2016
    Assignees: UNIVERSITY OF ROCHESTER, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Paul M. Dunman, Patrick D. Olson, Wayne Childers
  • SMALL MOLECULE RNASE INHIBITORS AND METHODS OF USE
    Publication number: 20160115124
    Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.
    Type: Application
    Filed: November 5, 2015
    Publication date: April 28, 2016
    Applicants: UNIVERSITY OF ROCHESTER, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, TEMPLE UNIVERSITY -- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Paul M. Dunman, Patrick D. Olson, Wayne Childers
  • Small molecule RNase inhibitors and methods of use
    Patent number: 9233095
    Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: January 12, 2016
    Assignees: University of Rochester, Board of Regents of the University of Nebraska, Temple University—Of the Commonwealth System of Higher Education
    Inventors: Paul M. Dunman, Patrick D. Olson, Wayne Childers
  • SMALL MOLECULE RNASE INHIBITORS AND METHODS OF USE
    Publication number: 20150283118
    Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease.
    Type: Application
    Filed: June 19, 2015
    Publication date: October 8, 2015
    Applicants: UNIVERSITY OF ROCHESTER, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, TEMPLE UNIVERSITY -- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Paul M. Dunman, Patrick D. Olson, Wayne Childers
  • METHODS AND COMPOSITIONS FOR TREATING INFECTION
    Publication number: 20150238473
    Abstract: Provided herein are compositions and methods for treating or preventing infection.
    Type: Application
    Filed: September 27, 2013
    Publication date: August 27, 2015
    Inventors: Paul M. Dunman, Damian J. Krysan, Daniel P. Flaherty
  • Small molecule RNase inhibitors and methods of use
    Patent number: 9089545
    Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: July 28, 2015
    Assignees: University of Rochester, Board of Regents of the University of Nebraska, Temple University—Of the Commonwealth System of Higher Education
    Inventors: Paul M. Dunman, Patrick D. Olson, Wayne Childers
  • SMALL MOLECULE RNASE INHIBITORS AND METHODS OF USE
    Publication number: 20130303585
    Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.
    Type: Application
    Filed: January 26, 2012
    Publication date: November 14, 2013
    Applicants: UNIVERSITY OF ROCHESTER, TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER LEARNING, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Paul M. Dunman, Patrick D. Olson, Wayne Childers