Patents by Inventor Paul M. GAROFOLO

Paul M. GAROFOLO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR KILLING A TARGET BACTERIUM
    Publication number: 20230038106
    Abstract: Provided herein are methods and compositions for killing a target bacterium. Also disclosed are engineered bacteriophages.
    Type: Application
    Filed: September 16, 2022
    Publication date: February 9, 2023
    Inventors: Paul M. GAROFOLO, David G. OUSTEROUT, Kurt SELLE, Sandi WONG, Hannah Hewitt TUSON
  • CRISPR CAS SYSTEMS AND LYSOGENY MODULES
    Publication number: 20220389392
    Abstract: Disclosed herein are compositions and methods for modifying a bacterial population. In some embodiments, described herein is a bacteriophage comprising a first nucleic acid sequence encoding a first spacer sequence or a crRNA transcribed therefrom, wherein the first spacer sequence is complementary to a target nucleotide sequence from a target gene in a target bacterium, provided that the bacteriophage is rendered lytic.
    Type: Application
    Filed: November 5, 2020
    Publication date: December 8, 2022
    Inventors: David G. OUSTEROUT, Paul M. GAROFOLO, Kurt SELLE, Hannah Hewitt TUSON
  • METHODS AND COMPOSITIONS FOR KILLING A TARGET BACTERIUM
    Publication number: 20220387531
    Abstract: Provided herein are methods and compositions for killing a target bacterium. Also disclosed are engineered bacteriophages.
    Type: Application
    Filed: July 6, 2022
    Publication date: December 8, 2022
    Inventors: Paul M. GAROFOLO, David G. OUSTEROUT, Kurt SELLE, Sandi WONG, Hannah Hewitt TUSON
  • METHODS AND COMPOSITIONS FOR KILLING A TARGET BACTERIUM
    Publication number: 20220380736
    Abstract: Provided herein are methods and compositions for killing a target bacterium. Also disclosed are engineered bacteriophages.
    Type: Application
    Filed: July 6, 2022
    Publication date: December 1, 2022
    Inventors: Paul M. GAROFOLO, David G. OUSTEROUT, Kurt SELLE, Sandi WONG, Hannah Hewitt TUSON
  • PHAGE COMPOSITIONS COMPRISING CRISPR-CAS SYSTEMS AND METHODS OF USE THEREOF
    Publication number: 20220370526
    Abstract: Disclosed here are phage compositions comprising CRISPR-Cas systems and methods of use thereof. In certain embodiments, disclosed herein is a bacteriophage comprising a nucleic acid sequence encoding a Type I CRISPR-Cas system comprising: (a) a CRISPR array; (b) a Cascade polypeptide; and (c) a Cas3 polypeptide. In some embodiments, the CRISPR array comprises a spacer sequence and at least one repeat sequence. In some embodiments, the at least one repeat sequence is operably linked to the spacer sequence at either its 5? end or its 3? end.
    Type: Application
    Filed: November 5, 2020
    Publication date: November 24, 2022
    Inventors: David G. OUSTEROUT, Paul M. GAROFOLO, Kurt SELLE, Hannah Hewitt TUSON
  • METHODS AND COMPOSITIONS FOR KILLING A TARGET BACTERIUM
    Publication number: 20220002681
    Abstract: Provided herein are methods and compositions for killing a target bacterium. Also disclosed are engineered bacteriophages.
    Type: Application
    Filed: September 8, 2021
    Publication date: January 6, 2022
    Inventors: Paul M. GAROFOLO, David G. Ousterout, Kurt Selle, Sandi Wong, Hannah Hewitt Tuson
  • METHODS AND COMPOSITIONS FOR KILLING A TARGET BACTERIUM
    Publication number: 20210161150
    Abstract: Provided herein are methods and compositions for killing a target bacterium with a CRISPR-Cpf1 system. Also disclosed are engineered bacteriophages.
    Type: Application
    Filed: May 24, 2019
    Publication date: June 3, 2021
    Inventors: Paul M. GAROFOLO, David G. OUSTEROUT, Kurt SELLE, Sandi WONG, Chase Lawrence BEISEL, Atul Kumar SINGH
  • METHODS AND COMPOSITIONS FOR KILLING A TARGET BACTERIUM
    Publication number: 20200354690
    Abstract: Provided herein are methods and compositions for killing a target bacterium. Also disclosed are engineered bacteriophages.
    Type: Application
    Filed: June 11, 2020
    Publication date: November 12, 2020
    Inventors: Paul M. GAROFOLO, David G. OUSTEROUT, Kurt SELLE, Sandi WONG, Hannah Hewitt TUSON