Abstract: Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor (G-CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device may include a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector may define a sterile fluid flowpath between the container and the insertion mechanism. Optionally, a cannula initially disposed about the needle may be included. The cannula may be retained in the patient at an injection site created by the needle after the needle is withdrawn from the patient. Methods of assembly and operation are also provided.

Abstract: A method of producing a hot, carburized metallized iron product in a generally vertical shaft furnace having an upper reducing zone in which iron oxide reacts with a gaseous reductant, and a lower carbon control and product discharge zone, including: establishing a gravitationally descending iron oxide burden in the furnace; reacting hot gaseous reductant with the descending burden to form a metallized iron product and a reacted top gas; and injecting a hydrocarbon gas mixture consisting of hot reformed endothermic gas and cool natural gas to the product discharge section of the shaft furnace; whereby the carbon content of the metallized iron pellet product is controlled by mixing the endothermic gas and natural gas in the proper ratio to balance the endothermic and exothermic reactions within the discharge zone of the furnace.