Patents by Inventor Paul M. Mathews

Paul M. Mathews has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Speaker assembly
    Patent number: 11950036
    Abstract: An electronic device can include a housing defining an aperture and a display positioned in the aperture. The display and the housing can define an internal volume in which a speaker assembly is positioned. The speaker assembly can include a speaker module and a speaker enclosure in fluid communication, with the speaker enclosure at least partially defining a speaker volume.
    Type: Grant
    Filed: February 7, 2023
    Date of Patent: April 2, 2024
    Assignee: APPLE INC.
    Inventors: Paul X. Wang, Chanjuan Feng, Christopher Wilk, Dinesh C. Mathew, Keith J. Hendren, Stuart M. Nevill, Daniel K. Boothe, Nicholas A Rundle, Simon S. Lee, Xiang Zhang, Thomas H. Tsang, Rebecca J. Mikolajczyk
  • Methods for the identification of compounds for the treatment of neuronal atrophy-associated dementia
    Patent number: 7090987
    Abstract: The invention features methods of diagnosing and treating a patient having Alzheimer's disease or other neuronal atrophy-associated dementia by determining or altering, respectively, the level of activity of pathways from the endoplasmic reticulum to lysosomes in the patient.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: August 15, 2006
    Inventors: Ralph A. Nixon, Anne M. Cataldo, Paul M. Mathews
  • Methods for the identification of compounds for the treatment of alzheimer's disease
    Patent number: 6838592
    Abstract: The invention features methods for identifying compounds useful for the treatment of Alzheimer's disease.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: January 4, 2005
    Assignee: Nathan S. Kline Institute for Psychiatric Research
    Inventors: Ralph A. Nixon, Anne M. Cataldo, Paul M. Mathews
  • Cell-based high-throughput screening methods
    Publication number: 20040253647
    Abstract: The present invention describes cell-based screening methods that allow for the elimination of false-positive results due to nonspecific toxicity of test compounds, while detecting those compounds that specifically modulate cellular metabolites in metabolic pathways associated with diseases and disorders, with particular regard to Alzheimer's disease. The methods are particularly suited to high-throughput screening techniques to identify compounds (drugs) that are effective in a cell-based system. The methods of the invention involve determining within a cell system the levels of both a metabolic precursor and a metabolite of interest and have broad application in high-throughput drug discovery and identification, particularly for precursor and metabolite molecules which are associated with disease and disease progression, such as Alzheimer's disease.
    Type: Application
    Filed: August 6, 2004
    Publication date: December 16, 2004
    Inventors: Paul M. Mathews, Ralph A. Nixon, Stephen D. Schmidt, Ying Jiang
  • Use of presenilin-1 for diagnosis of alzheimers disease
    Patent number: 5985581
    Abstract: The invention provides a method of diagnosing Alzheimer's disease. The method utilizes presenilin-1, whose level is found to be substantially decreased in Alzheimer's patients. Included in the invention are diagnostic kits for Alzheimer's disease and methods of screening for effective therapeutics for the disease. The invention also provides a method of studying the function and regulation of presenilin-1 in brain by the use of primate retinoblastoma cells.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: November 16, 1999
    Assignee: The McLean Hospital Corporation
    Inventors: Ralph A. Nixon, Anne M. Cataldo, Benjamin H. Kao, Paul M. Mathews