Patents by Inventor Paul M. Slattum

Paul M. Slattum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND THERAPEUTIC USES THEREOF
    Publication number: 20140349989
    Abstract: The invention relates to compounds, pharmaceutical compositions and methods useful for treating cancer, systemic or chronic inflammation, rheumatoid arthritis, diabetes, obesity, T-cell mediated autoimmune disease, ischemia, and complications associated with these diseases and disorders.
    Type: Application
    Filed: December 20, 2013
    Publication date: November 27, 2014
    Applicant: ALZHEIMER'S INSTITUTE OF AMERICA
    Inventors: Dange Vijay Kumar, Paul M. Slattum, Kraig M. Yager, Mark D. Shenderovich, Rajendra Tangallapally, Se-Ho Kim
  • COMPOUNDS AND THERAPEUTIC USES THEREOF
    Publication number: 20120122840
    Abstract: The invention relates to compounds, pharmaceutical compositions, and uses thereof, including therapeutic uses thereof, such as methods useful for treating cancer.
    Type: Application
    Filed: September 23, 2011
    Publication date: May 17, 2012
    Applicant: Myrexis, Inc.
    Inventors: Dange Vijay Kumar, Ian A. McAlexander, Matthew Gregory Bursavich, Christophe Hoarau, Paul M. Slattum, David A. Gerrish, Jeffrey W. Lockman, Weston R. Judd, Michael Saunders, Daniel P. Parker, Daniel Feodore Zigar, In Chul Kim, J. Adam Willardsen, Kraig M. Yager, Mark D. Shenderovich, Brandi L. Williams, Keith D. Tardif
  • Method for single-step attachment of a label to target molecules
    Patent number: 8129509
    Abstract: Compounds and methods are provided for a single-step covalent attachment of a label to a molecule comprising forming a covalently attachable labeling reagent for alkylating the molecule. Then, combining the covalently attachable labeling reagent with a mixture containing the molecule, under conditions wherein the labeling reagent has reactivity with the molecule thereby forming a covalent bond.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: March 6, 2012
    Assignee: Mirus Bio LLC
    Inventors: Paul M. Slattum, Jon A. Wolff, James E. Hagstrom, Vladimir G. Budker
  • Gene expression with covalently modified polynucleotides
    Patent number: 7491538
    Abstract: A process and compound wherein nucleic acids can be modified with a host of molecules and maintain their ability to be expressed. A modifying chemical attachment of polyions to polynucleotides can be used to facilitate the change of tertiary structure of the nucleic acid and in some cases condensation of nucleic acids into smaller, charged particles useful in delivering the nucleic acid to a cell.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: February 17, 2009
    Assignee: Mirus Bio LLC
    Inventors: Jon A. Wolff, Vladimir G. Budker, James E. Hagstrom, Paul M. Slattum
  • Process of making a compound by forming a polymer from a template drug
    Patent number: 7482160
    Abstract: A method of forming polymers in the presence of nucleic acid using template polymerization. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
    Type: Grant
    Filed: December 30, 2005
    Date of Patent: January 27, 2009
    Assignee: Roche Madison Inc.
    Inventors: Sean D. Monahan, David B. Rozema, Vladimir Trubetskoy, Paul M. Slattum, Jon A. Wolff, Vladimir G. Budker, James E. Hagstrom, Lisa J. Hanson
  • Charge Reversal of Polyion Complexes
    Publication number: 20080234222
    Abstract: An ionic polymer is utilized in “recharging” (another layer having a different charge) a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The resulting recharged complex can be formed with an appropriate amount of positive or negative charge such that the resulting complex has the desired net charge.
    Type: Application
    Filed: June 3, 2008
    Publication date: September 25, 2008
    Inventors: Jon A. Wolff, Vladimir S. Trubetskoy, Aaron G. Loomis, Paul M. Slattum, Sean D. Monahan, James E. Hagstrom, Vladimir G. Budker
  • Charge reversal of polyion complexes
    Patent number: 7396919
    Abstract: An ionic polymer is utilized in “recharging” (another layer having a different charge) a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The resulting recharged complex can be formed with an appropriate amount of positive or negative charge such that the resulting complex has the desired net charge.
    Type: Grant
    Filed: June 9, 1999
    Date of Patent: July 8, 2008
    Assignee: Mirus Bio Corporation
    Inventors: Jon A. Wolff, Vladimir S. Trubetskoy, Aaron G. Loomis, Paul M. Slattum, Sean D. Monahan, James E. Hagstrom, Vladimir G. Budker
  • Compounds and processes for single-pot attachment of a label to nucleic acid
    Patent number: 7326780
    Abstract: Compounds and methods are provided for a single-pot covalent attachment of a label to nucleic acids comprising forming a covalently attachable labeling reagent for alkylating the molecule. Then, combining the covalently attachable labeling reagent with a mixture containing the molecule, under conditions wherein the labeling reagent has reactivity with the molecule thereby forming a covalent bond.
    Type: Grant
    Filed: May 1, 2006
    Date of Patent: February 5, 2008
    Assignee: Mirus Bio Corporation
    Inventors: Paul M. Slattum, Jon A. Wolff, James E. Hagstrom, Vladimir G. Budker
  • Intravascular delivery of non-viral nucleic acid
    Patent number: 7148205
    Abstract: Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then the polynucleotide is inserted into a mammalian vessel such as a tail vein or artery. Prior to insertion, subsequent to insertion, or concurrent with insertion the permeability of the vessel is increased thereby the genetic material is delivered to the parenchymal cell altering endogenous properties of the cell.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: December 12, 2006
    Assignee: Mirus Bio Corporation
    Inventors: Sean D. Monahan, Jon A. Wolff, Paul M. Slattum, James E. Hagstrom, Vladimir G. Budker, David B. Rozema
  • Polyampholytes for delivering polyions to a cell
    Patent number: 7098030
    Abstract: An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
    Type: Grant
    Filed: July 26, 2004
    Date of Patent: August 29, 2006
    Assignee: Mirus Bio Corporation
    Inventors: David B. Rozema, Vladimir G. Budker, James E. Hagstrom, Vladimir Trubetskoy, Jon A. Wolff, Sean D. Monahan, Paul M. Slattum
  • Micellar systems
    Patent number: 7091041
    Abstract: A complex is described that is deliverable to a cell comprising inserting a nucleic acid or other cargo into a reverse micelle. The reverse micelle has the property to compact the nucleic acid for easier delivery.
    Type: Grant
    Filed: July 25, 2003
    Date of Patent: August 15, 2006
    Assignee: Mirus Bio Corporation
    Inventors: Sean D. Monahan, Jon A. Wolff, Paul M. Slattum, James E. Hagstrom, Vladimir G. Budker
  • Compound containing a labile disulfide bond
    Patent number: 7087770
    Abstract: A labile disulfide-containing compound under physiological conditions containing a labile disulfide bond and a transduction signal.
    Type: Grant
    Filed: February 8, 2001
    Date of Patent: August 8, 2006
    Assignee: Mirus Bio Corporation
    Inventors: Jon A. Wolff, Sean D. Monahan, Vladimir G. Budker, Paul M. Slattum, David B. Rozema
  • Gene expression with covalently modified polynucleotides
    Patent number: 7049142
    Abstract: A process and compound wherein nucleic acids can be modified with a host of molecules and maintain their ability to be expressed. A modifying chemical attachment of polyions to polynucleotides can be used to facilitate the change of tertiary structure of the nucleic acid and in some cases condensation of nucleic acids into smaller, charged particles useful in delivering the nucleic acid to a cell.
    Type: Grant
    Filed: August 2, 2000
    Date of Patent: May 23, 2006
    Assignee: Mirus Corporation
    Inventors: Jon A. Wolff, Paul M. Slattum, James E. Hagstrom, Vladimir G. Budker
  • Process of making a compound by forming a polymer from a template drug
    Patent number: 7049144
    Abstract: A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: May 23, 2006
    Assignee: Mirus Bio Corporation
    Inventors: Jon A. Wolff, James E. Hagstrom, Vladimir G. Budker, Vladimir S. Trubetskoy, Paul M. Slattum, Lisa J. Hanson
  • Process of making a compound by forming a polymer from a template drug
    Patent number: 7022525
    Abstract: A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
    Type: Grant
    Filed: January 12, 2004
    Date of Patent: April 4, 2006
    Assignee: Mirus Bio Corporation
    Inventors: Vladimir Trubetskoy, Jon A. Wolff, Paul M. Slattum, Lisa Hanson, Vladimir G. Budker, James E. Hagstrom
  • Process of making a compound by forming a polymer from a template drug
    Patent number: 6960690
    Abstract: A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: November 1, 2005
    Assignee: Mirns Bio Corporation
    Inventors: Jon A. Wolff, James E. Hagstrom, Vladimir G. Budker, Vladimir S. Trubetskoy, Paul M. Slattum, Lisa J. Hanson
  • Compound containing a labile disulfide bond
    Patent number: 6936729
    Abstract: A labile disulfide-containing compound under physiological conditions, comprising: the disulfide-containing compound having a labile disulfide bond that is either a disulfide bond that is cleaved more rapidly than oxidized glutathione or a disulfide bond constructed from thiols in which one of the constituent thiols has a lower pKa than glutathione or a disulfide bond that is activated by intramolecular attack from a free thiol.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: August 30, 2005
    Assignee: Mirus Bio Corporation
    Inventors: Jon A. Wolff, Sean D. Monahan, Vladimir G. Budker, Paul M. Slattum, David B. Rozema
  • Polynucleotide complex delivery
    Patent number: 6897068
    Abstract: Disclosed is a complex for providing nucleic acid expression in a cell. A polynucleotide and a polymer are mixed together to form the complex wherein the zeta potential of the complex is not positive. Then the complex is delivered to the cell wherein the nucleic acid is expressed.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: May 24, 2005
    Assignee: Mirus Bio Corporation
    Inventors: Sean D. Monahan, Jon A. Wolff, James E. Hagstrom, Vladimir G. Budker, DAvid B. Rozema, Paul M. Slattum
  • Process for delivering nucleic acids to cardiac tissue
    Patent number: 6867196
    Abstract: A process for delivering a nucleic acid to a cardiac tissue cell in a mammal is described, comprising introducing a composition consisting of a nucleic acid to a blood vessel, which subsequently delivers the nucleic acid to the cardiac tissue cell. The nucleic acid can be DNA or RNA or plasmid DNA or viral. This process is for purposes of gene therapy, and research.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: March 15, 2005
    Assignee: Mirus Bio Corporation
    Inventors: Jon A. Wolff, Hans Herweijer, Larry F. Whitesell, Matthew R. Wolff, Sean D. Monahan, Paul M. Slattum, James E. Hagstrom, Vladimir G. Budker, David B. Rozema
  • Intravascular delivery of non-viral nucleic acid
    Publication number: 20040259828
    Abstract: Disclosed is a system for providing nucleic acid expression in a cell. A polynucleotide is inserted into a mammalian vasculature. The vessel permeability is increased and the polynucleotide is delivered to the cell where it enhances the endogenous properties of the cell.
    Type: Application
    Filed: May 4, 2004
    Publication date: December 23, 2004
    Inventors: Jon A. Wolff, Vladimir G. Budker, James E. Hagstrom, Sean D. Monahan, David B. Rozema, Paul M. Slattum