Patents by Inventor Paul Manowitz

Paul Manowitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for detecting a predisposition to susceptibility to toxic effects of drugs and poisons
    Patent number: 5935790
    Abstract: The present invention relates to methods for diagnosis of susceptibility to neurotoxicity or the pathological effects of neurotoxicity based on detection of a genetic marker in an individual. The present invention is directed generally to methods and associated compositions and kits for detecting the presence of arylsulfatase A (ASA) pseudodeficiency (PD) mutations in humans. Detection of these mutations has been surprisingly found to be a strong indicator for susceptibility to neurotoxicity and/or susceptibility to toxicant's pathological effects, as well as an important marker in evaluating the likelihood of metachromatic leukodystrophy (MLD).
    Type: Grant
    Filed: August 5, 1997
    Date of Patent: August 10, 1999
    Assignees: Rutgers, The State University of New Jersey, University of Medicine and Dentistry of New Jersey
    Inventors: Ronald D. Poretz, Paul Manowitz
  • Marker for individuals susceptible to alcoholism
    Patent number: 5736325
    Abstract: The present invention relates to methods for diagnosis of susceptibility to alcoholism or the pathological effects of alcoholism based on detection of a genetic marker in an individual. The present invention is directed generally to methods and associated compositions and kits for detecting the presence of arylsulfatase A (ASA) pseudodeficiency (PD) mutations in humans. Detection of these mutations has been surprisingly found to be a strong indicator for susceptibility to alcoholism and/or susceptibility to alcohol's pathological effects, as well as an important marker in evaluating the likelihood of metachromatic leukodystrophy (MLD).
    Type: Grant
    Filed: August 31, 1994
    Date of Patent: April 7, 1998
    Assignee: Algene LLC
    Inventors: Paul Manowitz, Ronald D. Poretz, David Park, Michael Ricketts