Abstract: Embodiments of the present disclosure include systems and methods for providing a decentralized federation for attribute-based access control. A request for a list of unique identifiers (IDs) associated with members belonging to the federation is sent to a federation authority. For a unique ID in the list of unique IDs associated with a second member belonging to the federation, a set of communication information for communicating with the second member is determined. Based on the set of communication information associated with the second member, the second member is sent a request for a list of available services. The second member is provided a set of verifiable credentials associated with the first member. The second member determines the list of available services based on the set of verifiable credentials and a set of policies and rules. The list of available services is received from the second member.

Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.

Abstract: Disclosed is a method for enabling a plurality of players to play a two-dimensional, multiplayer video game that involves a plurality of game characters, each of which represented by a player, the characters deployed for combat within, at one time, one of a plurality of virtual battlefields, each battlefield comprising a plurality of platforms disposed parallel to one another, the characters adapted to be controllably moved between the plurality of platforms and perform a plurality of actions, the game generated by a game processor by executing a game software residing within a game memory, selectively associating a character with a player, each character selectively associated with at least one firearm, each of which is adapted to be controlled by the player, enabling the character to aim and fire a firearm at any angle with respect to the horizontal resulting in the targets being hit through the platforms.

Abstract: The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme.

Abstract: An improved method for the electro-coagulation c treatment of water and waste water includes an electrolytic cell having an anode and a helical cathode mounted longitudinally within a duct for receiving the contaminated water or waste water at one end and for discharging the treated water and electro-coagulated precipitates at the other end. The electro-coagulated precipitates can be subsequently separated by conventional flocculation, settlement and filtration systems. The anode forms a central longitudinal sacrificial rod defining a cylindrical outer surface and the helical cathode comprises an elongate wire coiled helically around and along the anode so as form a plurality of turns of the wire which turns are wrapped around the anode surface in the form of a constant helix of constant diameter with the turns spaced each from the next and spaced from the anode surface.

Abstract: The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R3, R5a, R6a, A, B, K, L, M, Y, Z, x, and m are defined herein, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R3, R5a, R6a, A, B, K, L, M, Y, Z, l, and m are defined herein, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R3, R5, R6, R13, A, B, Y, Z, x, and m are defined herein, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2a, R2b, Rya, R6a, A, B, K, L, M, Y, Z, l, and m are defined herein, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R5a, R6a, A, B, Y, I, and m are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme.

Abstract: An improved method for the electro-coagulation c treatment of water and waste water includes an electrolytic cell having an anode and a helical cathode mounted longitudinally within a duct for receiving the contaminated water or waste water at one end and for discharging the treated water and electro-coagulated precipitates at the other end. The electro-coagulated precipitates can be subsequently separated by conventional flocculation, settlement and filtration systems. The anode forms a central longitudinal sacrificial rod defining a cylindrical outer surface and the helical cathode comprises an elongate wire coiled helically around and along the anode so as form a plurality of turns of the wire which turns are wrapped around the anode surface in the form of a constant helix of constant diameter with the turns spaced each from the next and spaced from the anode surface.

Abstract: A ferrule for holding an array of optical fiber sections comprises a longitudinal cavity and an edge face. The longitudinal cavity receives the array of fiber sections with the end faces thereof arranged in a line and coplanar to each other. The edge face includes a first face portion perpendicular to the longitudinal axes of the fiber sections, and a second bevelled face portion adjacent to the first face portion. The end faces of the fiber sections emerge from the first face portion. The ferrule is used in a connector structure including a bar with a top surface on which optoelectronic devices are arranged in a line and bonding contacts are disposed. An alignment assembly between the ferrule and the bar aligns the end faces of the fiber sections with respective optoelectronic devices. The bevelled face portion provides for clearance to enable unobstructed passage of wire-bonds connected to the bonding contacts.

Abstract: A visualization tool for creating graphic displays of trace data produced by a parallel computer program execution monitoring system. The visualization tool contains a display monitor, possible input devices, a mass storage device, and a computer system. Trace data is converted into data structures and later pixel maps to ultimately generate processing activity diagrams for each processor in the computer system. If more than one processor is present, more than one processing activity diagram can be generated and simultaneously displayed on the same screen in form of strip graphs and for certain indicated time intervals. An average processor utilization diagram is then calculated and plotted on every processor activity diagram for comparison purposes. Browsing through these strip graphs all at the same time while comparing them against the average utilization graph will allow a user to easily redistribute workload if necessary and/or locate problem situations.

Abstract: A visualization tool for creating graphic displays of trace data produced by a parallel computer program execution monitoring system. The visualization tool contains a display monitor, possible input devices, a mass storage device, and a computer system. Trace data is converted into data structures and later pixel maps to ultimately generate processing activity diagrams for each processor in the computer system. If more than one processor is present, more than one processing activity diagram can be generated and simultaneously displayed on the same screen in form of strip graphs and for certain indicated time intervals. An average processor utilization diagram is then calculated and plotted on every processor activity diagram for comparison purposes. Browsing through these strip graphs all at the same time while comparing them against the average utilization graph will allow a user to easily redistribute workload if necessary and/or locate problem situations.

Abstract: A data ALU (arithmetic logic unit) (54) in a data processing system (20) performs both 24-bit arithmetic, and 16-bit exact arithmetic (including shifting and logical operations) using the same hardware. For a multiply/accumulate operation in 16-bit exact mode, shifting operations are used to align the operands so that 16-bit exact mode is transparent to a user. An entire instruction set can be executed in 24-bit mode or 16-bit exact mode. The same instructions and hardware are used in both modes. A transition between modes is performed by changing a status bit (97) in a status register (95).

Abstract: An integrated circuit chip includes a processor (4) and a memory (10) coupled by data and address buses (PAB, PDB). The memory is switchable between a first, standard, mode of operation in which a memory controller (14) is operative and a second, cache, mode of operation in which a cache controller (12) is operative by a switch (16, 22, 40). A memory area includes a valid bits array (VBA), a bit of which is set when a valid word is stored in a respective memory address of the memory in standard mode. If a valid bit exists corresponding to an address on the address bus, then information loaded into the memory in standard mode can be used by the processor in cache mode. The operating mode of the memory is switched using an operating mode register having a cache enable section, and a cache enable control line coupled to the memory. A reset arrangement is provided for resetting the valid bits array to flush the cache in a single operation.