Patents by Inventor Paul Martakos

Paul Martakos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10322213
    Abstract: Disclosed herein is the correlation of chemical properties of oils with the physical properties of a resulting cured oil composition. Also disclosed are biocompatible materials and coatings for medical devices prepared using enriched oils and methods for enhancing or modifying the physical and chemical characteristics of cured oils by enriching such oils with fatty acid alkyl esters. Methods of tailoring the properties of biocompatible materials and coatings to deliver one or more therapeutic agents are also provided.
    Type: Grant
    Filed: July 16, 2011
    Date of Patent: June 18, 2019
    Assignee: ATRIUM MEDICAL CORPORATION
    Inventors: Keith M. Faucher, Theresa K. Albergo, Paul Martakos
  • Patent number: 10285964
    Abstract: The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: May 14, 2019
    Assignee: ATRIUM MEDICAL CORPORATION
    Inventors: Thomas M. Swanick, Joseph Ferraro, Lisa Rogers, Paul Martakos
  • Publication number: 20190105430
    Abstract: Disclosed herein is the correlation of chemical properties of oils with the physical properties of a resulting cured oil composition. Also disclosed are biocompatible materials and coatings for medical devices prepared using enriched oils and methods for enhancing or modifying the physical and chemical characteristics of cured oils by enriching such oils with fatty acid alkyl esters. Methods of tailoring the properties of biocompatible materials and coatings to deliver one or more therapeutic agents are also provided.
    Type: Application
    Filed: December 7, 2018
    Publication date: April 11, 2019
    Applicant: ATRIUM MEDICAL CORPORATION
    Inventors: Keith M. FAUCHER, Theresa K. Albergo, Paul Martakos
  • Publication number: 20190054053
    Abstract: The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.
    Type: Application
    Filed: October 19, 2018
    Publication date: February 21, 2019
    Applicant: ATRIUM MEDICAL CORPORATION
    Inventors: Thomas M. SWANICK, Joseph FERRARO, Lisa ROGERS, Paul MARTAKOS
  • Publication number: 20180200306
    Abstract: A cured non-polymeric gel including a plurality of non-polymeric cross-links. The non-polymeric cross-links result from curing an oil or oil composition at selected curing conditions to achieve a desired amount of cross-linking to form the non-polymeric gel. The desired amount of cross-linking is selected based on a desired rate of degradation of the gel after the gel is implanted. The oil or oil composition comprises one or more of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or alpha-linolenic acid (ALA).
    Type: Application
    Filed: December 14, 2017
    Publication date: July 19, 2018
    Applicant: Atrium Medical Corporation
    Inventors: Roger LABRECQUE, Philip MCNAMARA, Joseph FERRARO, Lisa ROGERS, Paul MARTAKOS, Theodore KARWOSKI, Steve A. HERWECK, Keith M. FAUCHER, Thomas M. SWANICK
  • Patent number: 10016465
    Abstract: A cured non-polymeric gel including a plurality of non-polymeric cross-links. The non-polymeric cross-links result from curing an oil or oil composition at selected curing conditions to achieve a desired amount of cross-linking to form the non-polymeric get. The desired amount of cross-linking is selected based on a desired rate of degradation of the gel after the gel is implanted. The oil or oil composition comprises one or more of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or alphalinolenic acid (ALA).
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: July 10, 2018
    Assignee: ATRIUM MEDICAL CORPORATION
    Inventors: Roger Labrecque, Philip McNamara, Joseph Ferraro, Lisa Rogers, Paul Martakos, Theodore Karwoski, Steve A. Herweck, Keith M. Faucher, Thomas M. Swanick
  • Publication number: 20180133376
    Abstract: Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post-surgical adhesions.
    Type: Application
    Filed: November 17, 2017
    Publication date: May 17, 2018
    Applicant: ATRIUM MEDICAL CORPORATION
    Inventors: Thomas M. SWANICK, Joe BIENKIEWICZ, Joseph FERRARO, Paul MARTAKOS, Keith M. FAUCHER, Alicia DALE
  • Publication number: 20180050132
    Abstract: Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
    Type: Application
    Filed: October 26, 2017
    Publication date: February 22, 2018
    Applicant: ATRIUM MEDICAL CORPORATION
    Inventors: Keith M. FAUCHER, Hui TANG, Paul MARTAKOS, Theodore KARWOSKI, Allison SULLIVAN, Greg MELVILLE, Scott E. CORBEIL
  • Publication number: 20180043065
    Abstract: Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
    Type: Application
    Filed: October 20, 2017
    Publication date: February 15, 2018
    Applicant: ATRIUM MEDICAL CORPORATION
    Inventors: Keith M. FAUCHER, Hui TANG, Joseph FERRARO, Paul MARTAKOS, Theodore KARWOSKI, Scott CORBEIL
  • Publication number: 20180008650
    Abstract: A barrier layer and corresponding method of making provide anti-inflammatory, non-inflammatory, and anti-adhesion functionality for a medical device implantable in a patient. The barrier layer can be combined with a medical device structure to provide anti-adhesion characteristics, in addition to improved healing, non-inflammatory, and anti-inflammatory response. The barrier layer is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent.
    Type: Application
    Filed: September 20, 2017
    Publication date: January 11, 2018
    Applicant: ATRIUM MEDICAL CORPORATION
    Inventors: Joseph FERRARO, Lisa ROGERS, Paul MARTAKOS, Theodore KARWOSKI, Steve HERWECK, Keith FAUCHER, Phillip MCNAMARA
  • Patent number: 9844611
    Abstract: Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post-surgical adhesions.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: December 19, 2017
    Assignee: Atrium Medical Corporation
    Inventors: Thomas M. Swanick, Joe Bienkiewicz, Joseph Ferraro, Paul Martakos, Keith M. Faucher, Alicia Dale
  • Patent number: 9827352
    Abstract: Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: November 28, 2017
    Assignee: Atrium Medical Corporation
    Inventors: Keith M. Faucher, Hui Tang, Paul Martakos, Theodore Karwoski, Allison Sullivan, Greg Melville, Scott E. Corbeil
  • Patent number: 9827353
    Abstract: Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: November 28, 2017
    Assignee: Atrium Medical Corporation
    Inventors: Keith M. Faucher, Hui Tang, Joseph Ferraro, Paul Martakos, Theodore Karwoski, Scott E. Corbeil
  • Patent number: 9801982
    Abstract: A barrier device is formed of a barrier component that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. The barrier component can be a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The barrier device can have anchoring locations to provide an area on the barrier device to interface with an anchoring mechanism. The anchoring locations can include openings and/or anchor elements. The barrier device can also include truss structures that provide additional strength to the barrier component. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
    Type: Grant
    Filed: March 10, 2008
    Date of Patent: October 31, 2017
    Assignee: Atrium Medical Corporation
    Inventors: Steve A. Herweck, Joseph Ferraro, Paul Martakos, Theodore Karwoski, Anthony Richard Horton
  • Patent number: 9801913
    Abstract: A barrier layer and corresponding method of making provide anti-inflammatory, non-inflammatory, and anti-adhesion functionality for a medical device implantable in a patient. The barrier layer can be combined with a medical device structure to provide anti-adhesion characteristics, in addition to improved healing, non-inflammatory, and anti-inflammatory response. The barrier layer is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent.
    Type: Grant
    Filed: September 28, 2005
    Date of Patent: October 31, 2017
    Assignee: ATRIUM MEDICAL CORPORATION
    Inventors: Joseph Ferraro, Lisa Rogers, Paul Martakos, Theodore Karwoski, Steve A. Herweck, Keith Faucher, Philip McNamara
  • Patent number: 9682175
    Abstract: A coating material including a bio-absorbable cross-linked material and a cellular uptake inhibitor. The bio-absorbable cross-linked material includes two or more fatty acids cross-linked into a substantially random configuration by ester bonds. The coating material may be adhered to a medical device. A medical device system including a medical device and a coating is also included.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: June 20, 2017
    Assignee: Atrium Medical Corporation
    Inventors: Roger Labrecque, Geoffrey Moodie, Joseph F. Ferraro, Lisa Rogers, Paul Martakos, Theodore Karwoski, Steve A. Herweck
  • Patent number: 9592324
    Abstract: A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with reinforced sections or portions to aid with the fastening of the barrier device for implantation purposes and prohibits or substantially reduces the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: March 14, 2017
    Assignee: ATRIUM MEDICAL CORPORATION
    Inventors: Steve A. Herweck, Joseph Ferraro, Paul Martakos, Theodore Karwoski, Anthony Richard Horton
  • Patent number: 9492596
    Abstract: A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with anchoring reinforcements to aid with the fastening of the barrier device for implantation purposes and reinforcing truss sections or portions that prohibit or substantially reduce the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
    Type: Grant
    Filed: February 2, 2007
    Date of Patent: November 15, 2016
    Assignee: ATRIUM MEDICAL CORPORATION
    Inventors: Steve A. Herweck, Joseph Ferraro, Paul Martakos, Theodore Karwoski, Anthony Richard Horton
  • Publication number: 20160324816
    Abstract: The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.
    Type: Application
    Filed: July 22, 2016
    Publication date: November 10, 2016
    Applicant: ATRIUM MEDICAL CORPORATION
    Inventors: Thomas M. SWANICK, Joseph FERRARO, Lisa ROGERS, Paul MARTAKOS
  • Patent number: 9427423
    Abstract: The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.
    Type: Grant
    Filed: March 10, 2009
    Date of Patent: August 30, 2016
    Assignee: ATRIUM MEDICAL CORPORATION
    Inventors: Thomas M. Swanick, Joseph Ferraro, Lisa Rogers, Paul Martakos