Patents by Inventor Paul Martakos
Paul Martakos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11793912Abstract: Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.Type: GrantFiled: October 8, 2020Date of Patent: October 24, 2023Assignee: ATRIUM MEDICAL CORPORATIONInventors: Keith M. Faucher, Hui Tang, Paul Martakos, Theodore Karwoski, Alison Sullivan, Greg Melville, Scott E. Corbeil
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Patent number: 11166929Abstract: The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.Type: GrantFiled: October 19, 2018Date of Patent: November 9, 2021Assignee: ATRIUM MEDICAL CORPORATIONInventors: Thomas M. Swanick, Joseph Ferraro, Lisa Rogers, Paul Martakos
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Patent number: 11097035Abstract: Disclosed herein is the correlation of chemical properties of oils with the physical properties of a resulting cured oil composition. Also disclosed are biocompatible materials and coatings for medical devices prepared using enriched oils and methods for enhancing or modifying the physical and chemical characteristics of cured oils by enriching such oils with fatty acid alkyl esters. Methods of tailoring the properties of biocompatible materials and coatings to deliver one or more therapeutic agents are also provided.Type: GrantFiled: December 7, 2018Date of Patent: August 24, 2021Assignee: ATRIUM MEDICAL CORPORATIONInventors: Keith M. Faucher, Theresa K. Albergo, Paul Martakos
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Patent number: 11083823Abstract: Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post-surgical adhesions.Type: GrantFiled: November 17, 2017Date of Patent: August 10, 2021Assignee: ATRIUM MEDICAL CORPORATIONInventors: Thomas M. Swanick, Joe Bienkiewicz, Joseph Ferraro, Paul Martakos, Keith M. Faucher, Alicia Dale
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Publication number: 20210038772Abstract: A biomaterial including a plurality of fatty acid chains cross-linked together and elemental silver metal formed within the material. Method(s) for forming the material are also included. The silver-containing biomaterial can be utilized alone or in combination with a medical device for the release and local delivery of one or more anti-infective agents.Type: ApplicationFiled: October 14, 2020Publication date: February 11, 2021Applicant: ATRIUM MEDICAL CORPORATIONInventors: Keith M. FAUCHER, Hilda N. RONO, Anthony Richard HORTON, Jocelyn CHOROSZY, Paul MARTAKOS
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Publication number: 20210030928Abstract: Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.Type: ApplicationFiled: October 8, 2020Publication date: February 4, 2021Applicant: ATRIUM MEDICAL CORPORATIONInventors: Keith M. FAUCHER, Hui TANG, Paul MARTAKOS, Theodore KARWOSKI, Alison SULLIVAN, Greg MELVILLE, Scott E. CORBEIL
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Patent number: 10869902Abstract: A cured non-polymeric gel including a plurality of non-polymeric cross-links. The non-polymeric cross-links result from curing an oil or oil composition at selected curing conditions to achieve a desired amount of cross-linking to form the non-polymeric gel. The desired amount of cross-linking is selected based on a desired rate of degradation of the gel after the gel is implanted. The oil or oil composition comprises one or more of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or alpha-linolenic acid (ALA).Type: GrantFiled: December 14, 2017Date of Patent: December 22, 2020Assignee: ATRIUM MEDICAL CORPORATIONInventors: Roger Labrecque, Philip McNamara, Joseph Ferraro, Lisa Rogers, Paul Martakos, Theodore Karwoski, Steve A. Herweck, Keith M. Faucher, Thomas M. Swanick
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Patent number: 10864304Abstract: A material including a plurality of fatty acid chains cross-linked together and a silver fatty acid salt formed with the fatty acid chains within the material. Methods for forming a material are also included. The silver-containing materials can be utilized alone or in combination with a medical device for the release and local delivery of one or more anti-infective agents.Type: GrantFiled: May 19, 2014Date of Patent: December 15, 2020Assignee: ATRIUM MEDICAL CORPORATIONInventors: Keith M. Faucher, Hilda N. Rono, Anthony Richard Horton, Jocelyn Choroszy, Paul Martakos
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Patent number: 10814043Abstract: Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.Type: GrantFiled: October 26, 2017Date of Patent: October 27, 2020Assignee: ATRIUM MEDICAL CORPORATIONInventors: Keith M. Faucher, Hui Tang, Paul Martakos, Theodore Karwoski, Alison Sullivan, Greg Melville, Scott E. Corbeil
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Patent number: 10792312Abstract: A barrier layer and corresponding method of making provide anti-inflammatory, non-inflammatory, and anti-adhesion functionality for a medical device implantable in a patient. The barrier layer can be combined with a medical device structure to provide anti-adhesion characteristics, in addition to improved healing, non-inflammatory, and anti-inflammatory response. The barrier layer is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent.Type: GrantFiled: September 20, 2017Date of Patent: October 6, 2020Assignee: ATRIUM MEDICAL CORPORATIONInventors: Joseph Ferraro, Lisa Rogers, Paul Martakos, Theodore Karwoski, Steve Herweck, Keith Faucher, Phillip McNamara
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Patent number: 10772995Abstract: Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.Type: GrantFiled: October 20, 2017Date of Patent: September 15, 2020Assignee: ATRIUM MEDICAL CORPORATIONInventors: Keith M. Faucher, Hui Tang, Joseph Ferraro, Paul Martakos, Theodore Karwoski, Scott Corbeil
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Publication number: 20200171213Abstract: Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.Type: ApplicationFiled: October 20, 2017Publication date: June 4, 2020Applicant: ATRIUM MEDICAL CORPORATIONInventors: Keith M. FAUCHER, Hui TANG, Joseph FERRARO, Paul MARTAKOS, Theodore KARWOSKI, Scott CORBEIL
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Patent number: 10603153Abstract: A hernia patch supporting tissue in-growth conforms to a tissue wall upon surgical installation and fixation within a patient. The hernia patch can include a base and positioning straps. The base is formed of two layers that are affixed to each other around the perimeter of the patch, for example by stitching. A stabilizing washer is provided between the two layers, and the stitch is provided peripherally around the stabilizing washer, keeping the washer free-floating between the layers. The base, positioning straps, and stabilizing washer are formed of a structure that does not separate the layers of the implant or form a space in the form of a pocket, and promotes more uniform and confluent tissue incorporation or in-growth after implantation. The hernia patch may further include a hydrolysable bioabsorbable cross-linked coating of a fatty acid based material, such as an omega-3 fatty acid based material.Type: GrantFiled: November 23, 2015Date of Patent: March 31, 2020Assignee: ATRIUM MEDICAL CORPORATIONInventors: Anthony R Horton, Paul Martakos, Steve A Herweck, Theodore Karwoski, Joseph F Ferraro
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Patent number: 10322213Abstract: Disclosed herein is the correlation of chemical properties of oils with the physical properties of a resulting cured oil composition. Also disclosed are biocompatible materials and coatings for medical devices prepared using enriched oils and methods for enhancing or modifying the physical and chemical characteristics of cured oils by enriching such oils with fatty acid alkyl esters. Methods of tailoring the properties of biocompatible materials and coatings to deliver one or more therapeutic agents are also provided.Type: GrantFiled: July 16, 2011Date of Patent: June 18, 2019Assignee: ATRIUM MEDICAL CORPORATIONInventors: Keith M. Faucher, Theresa K. Albergo, Paul Martakos
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Patent number: 10285964Abstract: The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.Type: GrantFiled: July 22, 2016Date of Patent: May 14, 2019Assignee: ATRIUM MEDICAL CORPORATIONInventors: Thomas M. Swanick, Joseph Ferraro, Lisa Rogers, Paul Martakos
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Publication number: 20190105430Abstract: Disclosed herein is the correlation of chemical properties of oils with the physical properties of a resulting cured oil composition. Also disclosed are biocompatible materials and coatings for medical devices prepared using enriched oils and methods for enhancing or modifying the physical and chemical characteristics of cured oils by enriching such oils with fatty acid alkyl esters. Methods of tailoring the properties of biocompatible materials and coatings to deliver one or more therapeutic agents are also provided.Type: ApplicationFiled: December 7, 2018Publication date: April 11, 2019Applicant: ATRIUM MEDICAL CORPORATIONInventors: Keith M. FAUCHER, Theresa K. Albergo, Paul Martakos
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Publication number: 20190054053Abstract: The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.Type: ApplicationFiled: October 19, 2018Publication date: February 21, 2019Applicant: ATRIUM MEDICAL CORPORATIONInventors: Thomas M. SWANICK, Joseph FERRARO, Lisa ROGERS, Paul MARTAKOS
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Publication number: 20180200306Abstract: A cured non-polymeric gel including a plurality of non-polymeric cross-links. The non-polymeric cross-links result from curing an oil or oil composition at selected curing conditions to achieve a desired amount of cross-linking to form the non-polymeric gel. The desired amount of cross-linking is selected based on a desired rate of degradation of the gel after the gel is implanted. The oil or oil composition comprises one or more of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or alpha-linolenic acid (ALA).Type: ApplicationFiled: December 14, 2017Publication date: July 19, 2018Applicant: Atrium Medical CorporationInventors: Roger LABRECQUE, Philip MCNAMARA, Joseph FERRARO, Lisa ROGERS, Paul MARTAKOS, Theodore KARWOSKI, Steve A. HERWECK, Keith M. FAUCHER, Thomas M. SWANICK
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Patent number: 10016465Abstract: A cured non-polymeric gel including a plurality of non-polymeric cross-links. The non-polymeric cross-links result from curing an oil or oil composition at selected curing conditions to achieve a desired amount of cross-linking to form the non-polymeric get. The desired amount of cross-linking is selected based on a desired rate of degradation of the gel after the gel is implanted. The oil or oil composition comprises one or more of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or alphalinolenic acid (ALA).Type: GrantFiled: October 10, 2014Date of Patent: July 10, 2018Assignee: ATRIUM MEDICAL CORPORATIONInventors: Roger Labrecque, Philip McNamara, Joseph Ferraro, Lisa Rogers, Paul Martakos, Theodore Karwoski, Steve A. Herweck, Keith M. Faucher, Thomas M. Swanick
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Publication number: 20180133376Abstract: Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post-surgical adhesions.Type: ApplicationFiled: November 17, 2017Publication date: May 17, 2018Applicant: ATRIUM MEDICAL CORPORATIONInventors: Thomas M. SWANICK, Joe BIENKIEWICZ, Joseph FERRARO, Paul MARTAKOS, Keith M. FAUCHER, Alicia DALE