Patents by Inventor Paul Michael Smigelski, Jr.

Paul Michael Smigelski, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11726078
    Abstract: A device for rapid detection of a tuberculosis lipoarabinomannan (TB-LAM) is provided. The device includes a pre-concentrator unit for concentrating the TB-LAM comprising: an ion-exchange medium comprising one or more ligands configured to capture the TB-LAM from the source biological sample, wherein the captured-TB-LAM is eluted from the ion-exchange medium as an eluate comprising a concentrated form of TB-LAM; a cassette; a lateral flow assay unit disposed in the cassette; and an integration unit attached to the pre-concentrator unit and the cassette. The integration unit is configured to operatively couple and de-couple the pre-concentrator unit and the cassette. The pre-concentrator unit and the lateral flow assay unit disposed in the cassette are in a fluidic communication in a coupled form. The device for rapid detection of TB-LAM further comprises a dilutor unit.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: August 15, 2023
    Assignees: General Electric Company, Tokitae LLC
    Inventors: Matthew Jeremiah Misner, Gregory Andrew Grossmann, Cathryn Ellen Olsen, John Richard Nelson, David Roger Moore, Paul Michael Smigelski, Jr., John Thomas Connelly, Benjamin David Grant, Bernhard Hans Weigl
  • Patent number: 11714084
    Abstract: A rapid detection method of a target biomolecule comprising an antigenic moiety is provided. The method includes providing a source biological sample comprising the target biomolecule; contacting the source biological sample to an ion-exchange medium; eluting the captured-target biomolecule from the ion-exchange medium as an eluate, and loading the eluate to a rapid diagnostic testing device comprising an antibody. The eluate comprises a concentrated form of the biomolecule in a solution having a salt concentration greater than 150 mM. A concentration of the target biomolecule in the eluate is in a range from about 2× to 25× compared to a concentration of the biomolecule in the source biological sample. The target biomolecule binds to the antibody under the salt concentration of greater than 150 mM. A device for rapid detection of target biomolecule is also provided.
    Type: Grant
    Filed: November 5, 2020
    Date of Patent: August 1, 2023
    Assignee: General Electric Company
    Inventors: Matthew Jeremiah Misner, Gregory Andrew Grossmann, Cathryn Ellen Olsen, John Richard Nelson, Brian Christopher Bales, David Roger Moore, Paul Michael Smigelski, Jr.
  • Publication number: 20230191333
    Abstract: A spiral wound membrane module is suitable for use with high temperature water that may also have a high pH, for example steam injection produced water. The module uses a membrane with a polyphenylene sulfide (PPS) backing material. The feed spacer of the module may be made from polyphenylene sulfide (PPS) or ethylene chlorotrifluoroethylene (ECTFE). The permeate carrier may be made of a woven nylon (i.e. nylon 6, 6) fabric coated with high temperature epoxy. The core tube and anti-telescoping device may be made of polysulfone. In some examples, the module may be used at a temperature of up to 130° C. Optionally, the module may be used at a pH of 9.5 or more. In a filtration method, the module may be operated at a pressure in the range of 150 to 450 psi. The module may be operated at a generally constant pressure.
    Type: Application
    Filed: February 16, 2023
    Publication date: June 22, 2023
    Inventors: Paul Michael SMIGELSKI, JR., David OLSON, Rachel GETTINGS, Jack HOWSON, David MOORE, Deborah DE LA CRUZ, Hua WANG, Joel CARAHER
  • Patent number: 11607649
    Abstract: A spiral wound membrane module is suitable for use with high temperature water that may also have a high pH, for example steam injection produced water. The module uses a membrane with a polyphenylene sulfide (PPS) backing material. The feed spacer of the module may be made from polyphenylene sulfide (PPS) or ethylene chlorotrifluoroethylene (ECTFE). The permeate carrier may be made of a woven nylon (i.e. nylon 6, 6) fabric coated with high temperature epoxy. The core tube and anti-telescoping device may be made of polysulfone. In some examples, the module may be used at a temperature of up to 130° C. Optionally, the module may be used at a pH of 9.5 or more. In a filtration method, the module may be operated at a pressure in the range of 150 to 450 psi. The module may be operated at a generally constant pressure.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: March 21, 2023
    Assignee: BL TECHNOLOGIES, INC.
    Inventors: Paul Michael Smigelski, Jr., David Olson, Rachel Gettings, Jack Howson, David Moore, Deborah De La Cruz, Hua Wang, Joel Caraher
  • Publication number: 20200384420
    Abstract: A spiral wound membrane module is suitable for use with high temperature water that may also have a high pH, for example steam injection produced water. The module uses a membrane with a polyphenylene sulfide (PPS) backing material. The feed spacer of the module may be made from polyphenylene sulfide (PPS) or ethylene chlorotrifluoroethylene (ECTFE). The permeate carrier may be made of a woven nylon (i.e. nylon 6, 6) fabric coated with high temperature epoxy. The core tube and anti-telescoping device may be made of polysulfone. In some examples, the module may be used at a temperature of up to 130 ° C. Optionally, the module may be used at a pH of 9.5 or more. In a filtration method, the module may be operated at a pressure in the range of 150 to 450 psi. The module may be operated at a generally constant pressure.
    Type: Application
    Filed: February 8, 2019
    Publication date: December 10, 2020
    Inventors: Paul Michael SMIGELSKI, JR., David OLSON, Rachel GETTINGS, Jack HOWSON, David MOORE, Deborah DE LA CRUZ, Hua WANG, Joel CARAHER
  • Patent number: 10837962
    Abstract: A rapid detection method of a target biomolecule comprising an antigenic moiety is provided. The method includes providing a source biological sample comprising the target biomolecule; contacting the source biological sample to an ion-exchange medium; eluting the captured-target biomolecule from the ion-exchange medium as an eluate, and loading the eluate to a rapid diagnostic testing device comprising an antibody. The eluate comprises a concentrated form of the biomolecule in a solution having a salt concentration greater than 150 mM. A concentration of the target biomolecule in the eluate is in a range from about 2× to 25× compared to a concentration of the biomolecule in the source biological sample. The target biomolecule binds to the antibody under the salt concentration of greater than 150 mM. A device for rapid detection of target biomolecule is also provided.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: November 17, 2020
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Matthew Jeremiah Misner, Gregory Andrew Grossmann, Cathryn Ellen Olsen, John Richard Nelson, Brian Christopher Bales, David Roger Moore, Paul Michael Smigelski, Jr.
  • Patent number: 10830760
    Abstract: A device for rapid detection of a tuberculosis lipoarabinomannan (TB-LAM) is provided. The device includes a pre-concentrator unit for concentrating the TB-LAM comprising: an ion-exchange medium comprising one or more ligands configured to capture the TB-LAM from the source biological sample, wherein the captured-TB-LAM is eluted from the ion-exchange medium as an eluate comprising a concentrated form of TB-LAM; a cassette; a lateral flow assay unit disposed in the cassette; and an integration unit attached to the pre-concentrator unit and the cassette. The integration unit is configured to operatively couple and de-couple the pre-concentrator unit and the cassette. The pre-concentrator unit and the lateral flow assay unit disposed in the cassette are in a fluidic communication in a coupled form. The device for rapid detection of TB-LAM further comprises a dilutor unit.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: November 10, 2020
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Matthew Jeremiah Misner, Gregory Andrew Grossmann, Cathryn Ellen Olsen, John Richard Nelson, David Roger Moore, Paul Michael Smigelski, Jr., John Thomas Connelly, Benjamin David Grant, Bernhard Hans Weigl
  • Patent number: 10790731
    Abstract: A method of forming a coating on a component of an electrical machine is presented. The method includes coating a surface of the component with a ceramic material, via an electrophoretic process, to form a first coating. The method further includes contacting the first coating deposited by the electrophoretic process with a polymeric material to form a second coating. The method furthermore includes curing or melting the polymeric material in the second coating to form the coating including the ceramic material dispersed in a polymer matrix.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: September 29, 2020
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Weijun Yin, Anil Raj Duggal, Aharon Yakimov, Holly Ann Comanzo, Vijay Kumar Srivastava, Mohandas Nayak, Hao Huang, Oltea Puica Siclovan, Paul Michael Smigelski, Jr.
  • Patent number: 10569234
    Abstract: Provided herein are copolymers and copolymer compositions that are both hydrophilic and oleophobic. The copolymers include structural units derived from a fluoroalkyl monomer and a zwitterionic monomer. It further relates to membranes formed by coating a porous substrate with the copolymeric compositions. The copolymeric coating imparts hydrophilicity and oleophobicity/oil-tolerance to the membranes. The uses of such membranes as microfiltration membrane or ultrafiltration membrane are also provided.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: February 25, 2020
    Assignee: BL TECHNOLOGIES, INC.
    Inventors: Louisa Ruth Carr, Paul Michael Smigelski, Jr., Jason Michael Nichols, James Manio Silva
  • Patent number: 10518196
    Abstract: A separation device, system and associated method are provided herein for separation of particulates form a base fluid. The separation device comprises a first microchannel comprising a fluid inlet and a mesofluidic collection chamber. The mesofluidic collection chamber has a first side and a second side, wherein the mesofluidic collection chamber is operatively coupled to the first microchannel on the first side, and wherein the mesofluidic collection chamber comprises a first fluid outlet at the second side, such that the fluid inlet, first microchannel, and first fluid outlet are in fluidic communication via the mesofluidic collection chamber.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: December 31, 2019
    Assignee: General Electric Company
    Inventors: Christopher Michael Puleo, Craig Patrick Galligan, Gregory Andrew Grossman, Erik Leeming Kvam, Robert Scott Duthie, Kenneth Wayne Rigby, Paul Michael Smigelski, Jr., Victoria Eugenia Cotero, Jason William Castle, John Donald Burczak, James Edward Rothman
  • Publication number: 20190372441
    Abstract: A method of forming a coating on a component of an electrical machine is presented. The method includes coating a surface of the component with a ceramic material, via an electrophoretic process, to form a first coating. The method further includes contacting the first coating deposited by the electrophoretic process with a polymeric material to form a second coating. The method furthermore includes curing or melting the polymeric material in the second coating to form the coating including the ceramic material dispersed in a polymer matrix.
    Type: Application
    Filed: May 30, 2018
    Publication date: December 5, 2019
    Inventors: Weijun Yin, Anil Raj Duggal, Aharon Yakimov, Holly Ann Comanzo, Vijay Kumar Srivastava, Mohandas Nayak, Hao Huang, Oltea Puica Siclovan, Paul Michael Smigelski, JR.
  • Publication number: 20190187126
    Abstract: A device for rapid detection of a tuberculosis lipoarabinomannan (TB-LAM) is provided. The device includes a pre-concentrator unit for concentrating the TB-LAM comprising: an ion-exchange medium comprising one or more ligands configured to capture the TB-LAM from the source biological sample, wherein the captured-TB-LAM is eluted from the ion-exchange medium as an eluate comprising a concentrated form of TB-LAM; a cassette; a lateral flow assay unit disposed in the cassette; and an integration unit attached to the pre-concentrator unit and the cassette. The integration unit is configured to operatively couple and de-couple the pre-concentrator unit and the cassette. The pre-concentrator unit and the lateral flow assay unit disposed in the cassette are in a fluidic communication in a coupled form. The device for rapid detection of TB-LAM further comprises a dilutor unit.
    Type: Application
    Filed: December 20, 2017
    Publication date: June 20, 2019
    Inventors: Matthew Jeremiah MISNER, Gregory Andrew GROSSMANN, Cathryn Ellen OLSEN, John Richard NELSON, David Roger MOORE, Paul Michael SMIGELSKI, JR., John Thomas CONNELLY, Benjamin David GRANT, Bernhard Hans WEIGL
  • Publication number: 20190187142
    Abstract: A rapid detection method of a target biomolecule comprising an antigenic moiety is provided. The method includes providing a source biological sample comprising the target biomolecule; contacting the source biological sample to an ion-exchange medium; eluting the captured-target biomolecule from the ion-exchange medium as an eluate, and loading the eluate to a rapid diagnostic testing device comprising an antibody. The eluate comprises a concentrated form of the biomolecule in a solution having a salt concentration greater than 150 mM. A concentration of the target biomolecule in the eluate is in a range from about 2× to 25× compared to a concentration of the biomolecule in the source biological sample. The target biomolecule binds to the antibody under the salt concentration of greater than 150 mM. A device for rapid detection of target biomolecule is also provided.
    Type: Application
    Filed: December 20, 2017
    Publication date: June 20, 2019
    Inventors: Matthew Jeremiah Misner, Gregory Andrew Grossmann, Cathryn Ellen Olsen, John Richard Nelson, Brian Christopher Bales, David Roger Moore, Paul Michael Smigelski, JR.
  • Publication number: 20180001231
    Abstract: A separation device, system and associated method are provided herein for separation of particulates form a base fluid. The separation device comprises a first microchannel comprising a fluid inlet and a mesofluidic collection chamber. The mesofluidic collection chamber has a first side and a second side, wherein the mesofluidic collection chamber is operatively coupled to the first microchannel on the first side, and wherein the mesofluidic collection chamber comprises a first fluid outlet at the second side, such that the fluid inlet, first microchannel, and first fluid outlet are in fluidic communication via the mesofluidic collection chamber.
    Type: Application
    Filed: July 13, 2016
    Publication date: January 4, 2018
    Inventors: Christopher Michael Puleo, Craig Patrick Galligan, Gregory Andrew Grossmann, Erik Leeming Kvam, Robert Scott Duthie, Kenneth Wayne Rigby, Paul Michael Smigelski, JR., Victoria Eugenia Cotero, Jason William Castle, John Donald Burczak, James Edward Rothman
  • Publication number: 20170050154
    Abstract: Provided herein are copolymers and copolymer compositions that are both hydrophilic and oleophobic. The copolymers include structural units derived from a fluoroalkyl monomer and a zwitterionic monomer. It further relates to membranes formed by coating a porous substrate with the copolymeric compositions. The copolymeric coating imparts hydrophilicity and oleophobicity/oil-tolerance to the membranes. The uses of such membranes as microfiltration membrane or ultrafiltration membrane are also provided.
    Type: Application
    Filed: November 3, 2016
    Publication date: February 23, 2017
    Inventors: Louisa Ruth Carr, Paul Michael Smigelski, JR., Jason Michael Nichols, James Manio Silva
  • Patent number: 9517952
    Abstract: Provided herein are copolymers and copolymer compositions that are both hydrophilic and oleophobic. The copolymers include structural units derived from a fluoroalkyl monomer and a zwitterionic monomer. It further relates to membranes formed by coating a porous substrate with the copolymeric compositions. The copolymeric coating imparts hydrophilicity and oleophobicity/oil-tolerance to the membranes. The uses of such membranes as microfiltration membrane or ultrafiltration membrane are also provided.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: December 13, 2016
    Assignee: General Electric Company
    Inventors: Louisa Ruth Carr, James Manio Silva, Paul Michael Smigelski, Jr., Jason Nichols
  • Publication number: 20150265977
    Abstract: Methods for treating water containing dissolved solids, suspended solids, organic material, or combinations include contacting the water with a coated membrane comprising a coating material disposed on a membrane substrate, the coating material comprising structural units derived from a compound of formula I, a compound of formula II and a compound of formula III; wherein R1, R2, and R3 are, independently at each occurrence, C1-C12 alkyl; R4 is alkylsilyl; L1 is alkylurethanyl; L2 and L3 are, independently at each occurrence, alkyl; X is hydroxy, alkoxy, or alkylamino; and m, n, and p, independently at each occurrence, range between 4 and 9. The coated membrane is joined to a backing in membrane filtration apparatuses for use in the methods.
    Type: Application
    Filed: March 21, 2014
    Publication date: September 24, 2015
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Louisa Ruth Carr, Hongchen Dong, Paul Michael Smigelski, JR., Jason Louis Davis, Jason Michael Nichols
  • Publication number: 20150136712
    Abstract: Provided herein are copolymers and copolymer compositions that are both hydrophilic and oleophobic. The copolymers include structural units derived from a fluoroalkyl monomer and a zwitterionic monomer. It further relates to membranes formed by coating a porous substrate with the copolymeric compositions. The copolymeric coating imparts hydrophilicity and oleophobicity/oil-tolerance to the membranes. The uses of such membranes as microfiltration membrane or ultrafiltration membrane are also provided.
    Type: Application
    Filed: November 15, 2013
    Publication date: May 21, 2015
    Applicant: General Electric Company
    Inventors: Louisa Ruth Carr, James Manio Silva, Paul Michael Smigelski, JR., Jason Nichols
  • Patent number: 8940411
    Abstract: Energy efficient optoelectronic devices include an electroluminescent layer containing a polymer made up of structural units of formula I and II; wherein R1 and R2 are independently C22-44 hydrocarbyl, C22-44 hydrocarbyl containing one or more S, N, O, P, or Si atoms, oxaalkylaryl, or a combination thereof; R3 and R4 are independently H, C1-44 hydrocarbyl or C1-44 hydrocarbyl containing one or more S, N, O, P, or Si atoms, or R3 and R4, taken together, form a C2-10 monocyclic or bicyclic ring containing up to three S, N, O, P, or Si heteroatoms; and X is S, Se, or a combination thereof.
    Type: Grant
    Filed: April 25, 2011
    Date of Patent: January 27, 2015
    Assignee: General Electric Company
    Inventors: Joseph John Shiang, Paul Michael Smigelski, Jr.
  • Publication number: 20140261388
    Abstract: In an embodiment, an assembly, comprising: a glazing layer; a light absorbing layer; and a thermo-responsive layer between the glazing layer and the light absorbing layer. The thermo-responsive layer comprises a matrix polymer having a glass transition temperature and an inorganic filler, wherein the matrix polymer comprises 0.5 to 10 weight percent of repeat units derived from acrylonitrile, based upon a total weight of the matrix polymer. The refractive indices of the matrix polymer and the inorganic filler differ by less than or equal to 0.05 at 25° C.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicant: SABIC Innovative Plastics IP B.V.
    Inventors: William David Richards, Paul Michael Smigelski, JR., James Edward Pickett