Abstract: An optical projection tomography system comprises a support arranged to support an object (63) and to rotate the object between a plurality of orientations, a first imaging system (64) arranged to image the object from a first direction to form a first image, and a second imaging system arranged to image the object from a second direction to form a second image, data acquisition means (66, 67) arranged to acquire image data from the first and second images for each of the orientations and processing means arranged to process the image data to generate an image data set.

Abstract: An endoscope includes a light source operable to generate coherent incident light, and a plurality of imaging optical fibers that are arranged in a fiber bundle, arranged to receive light at a proximal end of the fiber bundle, and arranged to transmit light to a distal end of the fiber bundle. The endoscope further includes a spatial light phase modulator between the light source and the fiber bundle, and arranged to receive the incident light from the light source and to adjust the relative phase of the incident light entering each of the plurality of imaging optical fibers.

Abstract: An imaging apparatus comprising: A spatial light modulator (30) operable to receive incident light (34) representing an incident light image and to intensity modulate said incident light to form spatially modulated (38) light; and an image capture device (42) operable to receive said spatially modulated light and to detect an intensity value for different portions of said spatially modulated light to form a modulated light image therefrom; wherein said spatial light modulator attenuates different parts of said incident light by different proportions such that intensity values of said incident light image are given by a combination of intensity values of said modulated light image captured by said image capture device and data representing proportions of attenuation applied to corresponding parts of said incident light image by said spatial light modulator.

Abstract: An endoscope includes a light source operable to generate coherent incident light, and a plurality of imaging optical fibres that are arranged in a fibre bundle, arranged to receive light at a proximal end of the fibre bundle, and arranged to transmit light to a distal end of the fibre bundle. The endoscope further includes a spatial light phase modulator between the light source and the fibre bundle, and arranged to receive the incident light from the light source and to adjust the relative phase of the incident light entering each of the plurality of imaging optical fibres.

Abstract: The present invention provides an improved method of analysing and obtaining reliable data about the plasma membrane of single cells, using a microfluidic cell analyser. The microfluidic cell analyser of the invention comprises a single cell trap, a manipulator arranged to manipulate the outer surface of a cell in the trap, a detection zone in communication with the single cell trap and a detector.

Abstract: A confocal microscope 2 uses as a light source a two-dimensional array of light emitting diodes 4. A two-dimensional array of detector cells 18 in the form of a CCD camera array or a CMOS camera array is provided. A sequence of illumination patterns are generated by the array of light emitting diodes 4. A corresponding sequence of detection patterns are read from the two-dimensional array of detector cells 18. The light emitting diodes may be A1GaInN light emitting diodes generating light in the wavelength 250 nm to 500 nm. The confocal microscope 2 may be fitted to the tip of an endoscope 30.

Abstract: A gated optical image intensifier 10 is provided with multiple intensifying channels 20, 22, 24, 26 each supplied with radiation via a respective optical channel of an optical splitter. The separate intensifying channels are subject to gating by a sequence of time spaced gating signals generated by an electronic gating signal generator. The multi-channel gated optical image intensifier has particular utility in the field of fluorescence lifetime imaging.

Abstract: This invention relates to an optical device and system for producing a holographic optical element or digital hologram. Various techniques of producing digital holograms have been proposed. However, they tend to suffer from long exposure times, as well as problems associated with control of two or more independent beams of coherent light used to produce a hologram. Problems become even more acute as pixel size decreases. The present invention provides an optical device including: a beam deflector, adapted to deflect a collimated beam of coherent light to produce an incident beam; a beam splitter for producing first and second beams, said beams being displaced so that the angle of deflection of the first beam is the same but opposite to the angle of deflection of the second beam; and a combiner combines the first and second beams so as to produce an interference pattern at an output plane.

Abstract: A holographic imaging apparatus having a pulsed laser light source for generating an object beam and a reference beam whereby an object, obscured by a diffusing medium, is illuminated by the object beam. A real time interferogram recording medium is exposed to the coincidence of light reflected from the object and the reference beam to record an interferogram. A holographic image is then reconstructed from the interferogram and may be viewed and recorded. The pulsed laser light source generates a beam which is divided by a conventional beam splitter device into an object beam and a reference beam. The object beam is then diverged by a lens which forms a diverging object beam to illuminate the object. The reference beam is diverged through another lens to form a diverging reference beam which is directed so that it illuminates a photoreactive crystal.