Abstract: A microfluidics device includes a plurality of interaction cells and fluid control means including i) means for providing to the interaction cells a preparation fluid, ii) means for providing to the interaction cells a sample fluid, wherein each interaction cell receives a different sample fluid, and iii) means for thermal control. A plurality of cantilevers may be disposed in each of the interaction cells, the cells or chambers formed by a cartridge bottom and top that form the device, wherein each of the plurality of cantilevers is configured to deflect in response to an interaction involving a component of the sample fluid. The cantilevers in each cell are attached to a reference plane that controls for environmental factors or non-analyte deflections.