Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.

Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for ex ample through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.

Abstract: Examples of the present disclosure are related to systems and methods for voltage interfaces between legacy control systems and light sources. An example voltage interface may include a control loop including a first op-amp, an output loop including a second op-amp, and an optical isolator configured to electrically isolate the control loop from the output loop, the optical isolator being configured to receive an input signal from the control loop and transmit an output signal to the output loop.

Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for ex ample through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.

Abstract: Examples of the present disclosure are related to systems and methods for voltage interfaces between legacy control systems and light sources. An example voltage interface may include a control loop including a first op-amp, an output loop including a second op-amp, and an optical isolator configured to electrically isolate the control loop from the output loop, the optical isolator being configured to receive an input signal from the control loop and transmit an output signal to the output loop.

Abstract: Implementations disclosed herein are directed towards low voltage electrical distribution systems. The systems may include an alternating current (AC) power source configured to generate a three-phase AC power signal, a three-conductor cable coupled to the AC power source, at least one rectifier coupled to the three-conductor cable, in which the at least one rectifier is configured to convert the three-phase AC power signal to a DC power signal, and at least one electrical load coupled to the at least one rectifier.

Abstract: Examples of the present disclosure are related to systems and methods for voltage interfaces between legacy control systems and light sources. An example voltage interface may include a control loop including a first op-amp, an output loop including a second op-amp, and an optical isolator configured to electrically isolate the control loop from the output loop, the optical isolator being configured to receive an input signal from the control loop and transmit an output signal to the output loop.

Abstract: Examples of the present disclosure are related to systems and methods for voltage interfaces between legacy control systems and light sources. An example voltage interface may include a control loop including a first op-amp, an output loop including a second op-amp, and an optical isolator configured to electrically isolate the control loop from the output loop, the optical isolator being configured to receive an input signal from the control loop and transmit an output signal to the output loop.

Abstract: Examples of the present disclosure are related to systems and methods for voltage interfaces between legacy control systems and light sources. An example voltage interface may include a control loop including a first op-amp, an output loop including a second op-amp, and an optical isolator configured to electrically isolate the control loop from the output loop, the optical isolator being configured to receive an input signal from the control loop and transmit an output signal to the output loop.

Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.

Abstract: Examples of the present disclosure are related to systems and methods for voltage interfaces between legacy control systems and light sources. An example voltage interface may include a control loop including a first op-amp, an output loop including a second op-amp, and an optical isolator configured to electrically isolate the control loop from the output loop, the optical isolator being configured to receive an input signal from the control loop and transmit an output signal to the output loop.

Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.

Abstract: A novel safety harness is disclosed. The safety harness has straps for securing upon a subject. Arranged around the straps are several light emitting diodes (LEDs). The LEDs are driven by pulses of current that exceed the power rating of the LED, but the current is driven for a very short period of time, such that the LEDs are not destroyed. These LEDs blink when turned on and emit substantially more light than is typically found in LEDs, such that the subject is visible from a distance of up to two thousand feet. Multiple safety harnesses may be strapped together, allowing the safety device to be used in a variety of settings, both for human and non-human subjects.

Abstract: Method and apparatus for remotely controlling a fire protection system for buildings. This method of fire protection uses a wireless or wired control system to remotely activate a fire protection system by sending it an activation signal or activation message wherein one or more commands can configure the system with specified operation instructions. The system utilizes roof top sprinklers and may additionally utilize existing irrigation systems or additional zones only used during the prevention of wildfires to wet down area in advance of fires. The system can be controlled by various municipal fire authorities that are given the authority to control fires. Immediate control of the system is always available to the transmitting authority. When activated, the central processor communicates to the authority that activated the fire protection system.

Abstract: A novel safety harness is disclosed. The safety harness has straps for securing upon a subject. Arranged around the straps are several light emitting diodes (LEDs). The LEDs are driven by pulses of current that exceed the power rating of the LED, but the current is driven for a very short period of time, such that the LEDs are not destroyed. These LEDs blink when turned on and emit substantially more light than is typically found in LEDs, such that the subject is visible from a distance of up to two thousand feet. Multiple safety harnesses may be strapped together, allowing the safety device to be used in a variety of settings, both for human and non-human subjects.

Abstract: A water irrigation system may include a computer system, a sensing unit, an irrigation controller, and/or a water delivery system. The sensing unit may include a moisture gauge. A rate of evaporation of moisture from a collector of a moisture gauge may be within about 10% of an average rate of evaporation of moisture from a zone to be irrigated. The sensing unit may assess an amount of moisture in the collector and provide output that is a function of the amount of moisture in the collector to the computer system. The computer system may control irrigation of the zone to be irrigated at least partially based on the assessed amount of moisture in the collector. A method of controlling irrigation may include receiving moisture in a collector and controlling irrigation of a zone to be irrigated at least partially based on an assessed amount of moisture in the collector.

Abstract: A water irrigation system may include a computer system, a sensing unit, an irrigation controller, and/or a water delivery system. The computer system may include regional evapotranspiration. The sensing unit may assess climatological conditions and provide output that is a function of the climatological conditions to the computer system. The computer system may assess zonal evapotranspiration at least partially based on the output provided by the sensing unit. The computer system may assess an irrigation need of the zone to be irrigated at least partially based on the regional evapotranspiration and the assessed zonal evapotranspiration. A method of controlling irrigation may include assessing climatological conditions, assessing zonal evapotranspiration based at least on the assessed climatological conditions, and controlling irrigation of the zone to be irrigated at least partially based on regional evapotranspiration and the assessed zonal evapotranspiration.

Abstract: An auxiliary sprinkler system control unit that interrupts a sprinkler system when ambient temperature is below thirty six degrees and when wind velocity is above ten miles per hour and when one half inch of water has been measured and delays the sprinkler for one day when in each month a daily running total of water addition is greater than a daily running total of an expected evapotranspiration or soil evaporation and plant transpiration rate as published for a specific area; said unit thereby providing a minimum amount of water to keep a healthy but slow growing turf.