Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: An augmented reality (AR) platform supports concurrent operation of multiple AR applications developed by third-party software developers. The AR platform may include an application programming interface (API) that third-party software developers can use to integrate features of the AR platform into the overall user experience of their AR applications. The AR platform includes a feature set having a variety of AR-specific features that interact with and are accessible to the AR applications or AR layers that define a collection of AR content.

Abstract: A handheld injection device includes a housing containing a cartridge, a dose setting means being operable in a first direction to set a desired dose to be dispensed, a piston rod being adapted to cooperate with a piston so as to cause a set dose to be injected from the cartridge, and a first clicker component, which is largely rotationally constrained to the housing, and a second clicker component, which is rotatable relative to the housing during dose dispensing. The clicker components are adapted to contact each other only at the end of dispensing of a set dose to thereby provide an audible and/or tactile first feedback to a user. The first clicker component is displaceable relative to the housing between a proximal dose setting position and a distal dose dispensing position.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: A housing of a device comprises a screw boss that extends outwardly from a first base plate proximate to a corner of the housing. Additionally, the housing of the device includes a force dissipation member. The force dissipation member includes a central portion that is sized to detachably attach around the screw boss. The force dissipation member further includes at least two arms that extend outwardly from the central portion, wherein each arm of the at least two arms is attached to a different side of the two walls of the housing.

Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least sectionwise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid metal chelate compound that is differentially retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by introducing into at least one of the malignant solid tumors one or more agents capable of stimulating specific immune cells within the tumor microenvironment, or by performing another method of in situ tumor vaccination. In a non-limiting example, the radioactive phospholipid metal chelate compound has the formula: wherein R1 comprises a chelating agent that is chelated to a metal atom, wherein the metal atom is an alpha, beta or Auger emitting metal isotope with a half life of greater than 6 hours and less than 30 days. In one such embodiment, a is 1, n is 18, m is 0, b is 1, and R2 is —N+(CH3)3.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: A handheld injection device includes a housing containing a cartridge, a dose setting means being operable in a first direction to set a desired dose to be dispensed, a piston rod being adapted to cooperate with a piston so as to cause a set dose to be injected from the cartridge, and a first clicker component, which is largely rotationally constrained to the housing, and a second clicker component, which is rotatable relative to the housing during dose dispensing. The clicker components are adapted to contact each other only at the end of dispensing of a set dose to thereby provide an audible and/or tactile first feedback to a user. The first clicker component is displaceable relative to the housing between a proximal dose setting position and a distal dose dispensing position.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: An electronic system comprising: at least one user interface member configured to be manipulated by a user for performing a dose setting operation of the drug delivery device and/or for performing a dose delivery operation for delivering a set dose, an electronic control unit configured to control operation of the electronic system, an electrical signaling unit configured to provide at least one electrical signal when the user interface member is manipulated, and a manipulation evaluation unit configured to evaluate the at least one electrical signal of the signaling unit to determine whether the manipulation of the user interface member indicated by the at least one signal of the signaling unit qualifies as an activation operation. The electronic control unit is configured to switch the electronic system into a higher power consumption when the manipulation evaluation unit has confirmed that the manipulation qualifies as activation operation.

Abstract: An electronic system for a drug delivery device is disclosed. The electronic system comprises a dose setting and drive mechanism. The dose setting and drive mechanism comprises a first member and a button module. The dose setting and drive mechanism is configured such that, at least in the dose delivery operation and/or in the dose setting operation, the first member moves relative to the button module. The electronic system has at least a first low power consumption state and a second high power consumption state. A rotation and/or axial movement of the button module relative to the first member generates a movement component of the at least one switch member relative to the button module and the first member, which triggers switching between the first low power consumption state and the second high power consumption state.

Abstract: The invention relates to an arrangement for detecting a position of a plunger (4) relative to a bung (3) in a drug cartridge (1), comprising a proximity sensor (5) located close to a distal end (6) of the plunger (4) facing the bung (3) and aligned to receive light reflected by the bung (3).

Abstract: In various embodiments, an apparatus, a non-transitory computer-readable media, and a method are provided, involving a technique to: receive, from at least one other node in a network, a plurality of segment identifiers, utilizing at least one of a link state protocol, a distance vector protocol, or a path vector protocol, store, in a data structure, the plurality of segment identifiers associated with nodes represented in a topology of at least a portion of a network, select, from the plurality of segment identifiers in the data structure and based on a specified policy, a first sequence of segment identifiers that identify a first sequence of at least one of: one or more nodes, one or more network interfaces, or one or more network regions, at least partially in a first path segment that communicatively couples the transmitting node with a receiving node in the network and that includes at least one particular node which is not predetermined by the first sequence of segment identifiers such that the at leas

Abstract: Methods and systems are described for detecting movement of a portable electronic device; receiving video data, for a first object, captured by a video capture device during the movement; and utilizing the video data, presenting a video by a display device of the portable electronic device that is viewable to a user for directing an attention of the user in connection with the first object.

Abstract: In various embodiments, a method and apparatus are configured to receive information associated with a path from a first node to a second node; and generate a set of one or more segment identifiers at least one of which is in an address space having a span in a current region in which the first node resides, and is configured for use in identifying a next region, wherein the set of one or more segment identifiers encodes the path.

Abstract: Methods and systems are described for detecting, in an output space having at least one dimension, a first location of a subspace, wherein a first user interface element of a first operating instance of an operable entity is presented, based on the first location, in the subspace location and a user interface element of a second operating instance of an operable entity is presented, based on the first location, in the subspace. The method further includes receiving an indication to change the subspace and changing the subspace to have a second location in the output space, wherein the first user interface element and the second user interface element are each presented, based on the second location, in the changed subspace.

Abstract: An electronic system for a drug delivery device is provided. The system includes an electronic control unit configured to control an operation of the system, and an electrical motion sensing unit that is configured to generate one or more data signals. The data signals are suitable to quantify relative rotational movement between a first member and a second member during a dose setting operation for setting a dose to be delivered by the drug delivery device and/or a dose delivery operation for delivering the set dose. The system is configured to perform a comparison operation to compare first data to second data. The first data indicating a first relative angular position of the first member and the second member, and being derivable from one or more data signals. The second data indicating a second relative angular position of the first member and the second member.