Abstract: A system and method to create a robust topology of a layout of cores for performing a function on an array of cores arranged in a grid is disclosed. A defective core file of location of defective cores in the array and an optimal ideal topology of a configuration layout of at least some of the cores is input. The location of at least one defective core of the array is determined. At least some of the cores in the array of cores are assigned to the optimal initial topography of cores in the array. It is determined whether at least one defective core is in the optimal initial topography. The functions of the cores in the row and the column of the at least one defective core are assigned to additional neighboring cores in the array of cores to create the robust topology.

Abstract: Antibodies that bind the tumor (T) antigen of the Merkel cell polyomavirus are disclosed. The antibodies can be use used in cell-based immunotherapies, antibody-based therapies, diagnostics, and detection assays, among other uses.

Abstract: The present disclosure provides binding proteins and TCRs with high affinity and specificity against Merkel cell polyomavirus T antigen epitopes or peptides, T cells expressing such high affinity Merkel cell polyomavirus T antigen specific TCRs, nucleic acids encoding the same, and compositions for use in treating Merkel cell carcinoma.

Abstract: Disclosed is, inter alia, a method of reducing UVB-induced wrinkles in a subject, the method that includes: administering to a subject having, or at risk for, UVB-induced wrinkle, a composition comprising an agent that inhibits ATR mediated signaling.